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  • Wu, Wendy Yi-YingUmeå universitet,Onkologi (author)

Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers : A retrospective nested case-control study in two prospective cohorts

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-11-05
  • John Wiley & Sons,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-201192
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201192URI
  • https://doi.org/10.1002/ijc.34340DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample <3 years prior to diagnosis. Conditional logistic regression was used to estimate the association between EarlyCDT-Lung test results and lung cancer risk. Sensitivity and specificity of the EarlyCDT-Lung test were calculated in all subjects and subgroups based on age, smoking history, lung cancer stage, sample collection time before diagnosis and year of sample collection. The overall lung cancer odds ratios were 0.89 (95% CI: 0.34-2.30) for a moderate risk EarlyCDT-Lung test result and 1.09 (95% CI: 0.48-2.47) for a high-risk test result compared to no significant test result. The overall sensitivity was 8.4% (95% CI: 4.6-14) and overall specificity was 92% (95% CI: 87-96) when considering a high-risk result as positive. Stratified analysis indicated higher sensitivity (17%, 95% CI: 7.2-32.1) in subjects with blood drawn up to 1 year prior to diagnosis. In conclusion, our study does not support a role of the EarlyCDT-Lung test in identifying the high-risk subjects in ever-smokers for lung cancer screening in the EPIC and NSHDS cohorts.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Haider, ZahraUmeå universitet,Onkologi(Swepub:umu)zaha0008 (author)
  • Feng, XiaoshuangGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (author)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Tjønneland, AnneDiet, Cancer and Health, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark (author)
  • Agudo, AntonioUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group, Epidemiology, Public Health Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (author)
  • Masala, GiovannaInstitute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy (author)
  • Robbins, Hilary A.Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (author)
  • Huerta, María-JoséDepartment of Epidemiology, Murcia Regional Health Council, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (author)
  • Guevara, MarcelaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain (author)
  • Schulze, Matthias B.German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (author)
  • Rodriguez-Barranco, MiguelCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain (author)
  • Vineis, PaoloMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Tumino, RosarioHyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy (author)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany; Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), Heidelberg, Germany (author)
  • Fortner, Renée T.Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany (author)
  • Sieri, SabinaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy (author)
  • Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia Federico II Universioty, Naples, Italy (author)
  • Nøst, Therese HaugdahlDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (author)
  • Sandanger, Torkjel M.Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (author)
  • Braaten, TonjeDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (author)
  • Johansson, MattiasGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (author)
  • Melin, Beatrice S.Umeå universitet,Onkologi(Swepub:umu)bema0010 (author)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (author)
  • Umeå universitetOnkologi (creator_code:org_t)

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