A cross-sectional and longitudinal analysis of pre-diagnostic blood plasma biomarkers for early detection of pancreatic cancer

Mason, James E.Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM) (author)

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death that typically presents at an advanced stage. No reliable markers for early detection presently exist. The prominent tumor stroma represents a source of circulating biomarkers for use together with cancer cell-derived biomarkers for earlier PDAC diagnosis. CA19-9 and CEA (cancer cell-derived biomarkers), together with endostatin and collagen IV (stroma-derived) were examined alone, or together, by multivariable modelling, using pre-diagnostic plasma samples (n = 259 samples) from the Northern Sweden Health and Disease Study biobank. Serial samples were available for a subgroup of future patients. Marker efficacy for future PDAC case prediction (n = 154 future cases) was examined by both cross-sectional (ROC analysis) and longitudinal analyses. CA19-9 performed well at, and within, six months to diagnosis and multivariable modelling was not superior to CA19-9 alone in cross-sectional analysis. Within six months to diagnosis, CA19-9 (AUC = 0.92) outperformed the multivariable model (AUC = 0.81) at a cross-sectional level. At diagnosis, CA19-9 (AUC = 0.995) and the model (AUC = 0.977) performed similarly. Longitudinal analysis revealed increases in CA19-9 up to two years to diagnosis which indicates a window of opportunity for early detection of PDAC.

Lundberg, Erik,1975-Umeå universitet,Kirurgi(Swepub:umu)erlu0002 (author)
Jonsson, PärUmeå universitet,Kemiska institutionen(Swepub:umu)parjon95 (author)
Nyström, Hanna,1980-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Kirurgi(Swepub:umu)haanym01 (author)
Franklin, Oskar,1985-Umeå universitet,Kirurgi(Swepub:umu)osfr0002 (author)
Lundin, Christina,1970-Umeå universitet,Kirurgi(Swepub:umu)chlu0008 (author)
Naredi, Peter,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xnarpe (author)
Antti, Henrik,1970-Umeå universitet,Kemiska institutionen(Swepub:umu)hean0004 (author)
Sund, MalinUmeå universitet,Kirurgi,Department of Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021 (author)
Öhlund, Daniel,1979-Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)dalohd00 (author)
Umeå universitetOnkologi (creator_code:org_t)

By the author/editor: Mason, James E.; Lundberg, Erik, ...; Jonsson, Pär; Nyström, Hanna, ...; Franklin, Oskar, ...; Lundin, Christin ...; show more...; Naredi, Peter, 1 ...; Antti, Henrik, 1 ...; Sund, Malin; Öhlund, Daniel, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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