Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

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Ishigaki, KazuyoshiCenter for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Article/chapterEnglish2022

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2022-11-04
Springer Nature,2022
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-201222
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201222URI
https://doi.org/10.1038/s41588-022-01213-wDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:151145920URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10−8), of which 34 are novel. Candidate genes at the novel loci suggest essential roles of the immune system (for example, TNIP2 and TNFRSF11A) and joint tissues (for example, WISP1) in RA etiology. Multi-ancestry fine-mapping identified putatively causal variants with biological insights (for example, LEF1). Moreover, PRS based on multi-ancestry GWAS outperformed PRS based on single-ancestry GWAS and had comparable performance between populations of European and East Asian ancestries. Our study provides several insights into the etiology of RA and improves the genetic predictability of RA.

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Sakaue, SaoriCenter for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States (author)
Terao, ChikashiLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan; The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (author)
Luo, YangCenter for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States (author)
Sonehara, KyutoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan (author)
Yamaguchi, KensukeDepartment of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)
Amariuta, TiffanyCenter for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, United States; Department of Medicine, University of California San Diego, La Jolla, CA, United States (author)
Too, Chun LaiImmunogenetics Unit, Allergy and Immunology Research Center, Institute for Medical Research, National Institutes of Health Complex, Ministry of Health, Kuala Lumpur, Malaysia; Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden (author)
Laufer, Vincent A.Karolinska Institutet (author)
Scott, Ian C.Haywood Academic Rheumatology Centre, Haywood Hospital, Midlands Partnership NHS Foundation Trust, Burslem, United Kingdom; Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Keele, United Kingdom (author)
Viatte, SebastienCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom (author)
Takahashi, MeikoCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (author)
Ohmura, KoichiroDepartment of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan (author)
Murasawa, AkiraDepartment of Rheumatology, Niigata Rheumatic Center, Niigata, Japan (author)
Hashimoto, MotomuDepartment of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Clinical Immunology, Graduate School of Medicine, Osaka City University, Osaka, Japan (author)
Ito, HiromuDepartment of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Orthopaedic Surgery, Kurashiki Central Hospital, Kurashiki, Japan (author)
Hammoudeh, MohammedRheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar (author)
Emadi, Samar AlRheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar (author)
Masri, Basel K.Department of Internal Medicine, Jordan Hospital, Amman, Jordan (author)
Halabi, HusseinSection of Rheumatology, Department of Internal Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia (author)
Badsha, HumeiraDr. Humeira Badsha Medical Center, Emirates Hospital, Dubai, United Arab Emirates (author)
Uthman, Imad W.Department of Rheumatology, American University of Beirut, Beirut, Lebanon (author)
Wu, XinDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China (author)
Lin, LiKarolinska Institutet (author)
Li, TingDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China (author)
Plant, DarrenCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom (author)
Barton, AnneCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom (author)
Orozco, GiselaCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom (author)
Verstappen, Suzanne M. M.NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom; Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, United Kingdom (author)
Bowes, JohnCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom (author)
MacGregor, Alexander J.Norwich Medical School, University of East Anglia, Norwich, United Kingdom (author)
Honda, SuguruInstitute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Department of Rheumatology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan (author)
Koido, MasaruLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)
Tomizuka, KoheiLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)
Kamatani, YoichiroLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan (author)
Tanaka, HiroakiThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan (author)
Tanaka, EiichiInstitute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Department of Rheumatology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan (author)
Suzuki, AkariLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)
Maeda, YuichiIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan; Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan (author)
Yamamoto, KenichiDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan (author)
Miyawaki, SatoruDepartment of Neurosurgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan (author)
Xie, GangLunenfeld-Tanenbaum Research Institute, ON, Toronto, Canada (author)
Zhang, JinyiLunenfeld-Tanenbaum Research Institute, ON, Toronto, Canada; Department of Medicine, University of Toronto, ON, Toronto, Canada (author)
Amos, Christopher I.Baylor College of Medicine, TX, Houston, United States (author)
Keystone, EdwardThe University of Toronto, ON, Toronto, Canada (author)
Wolbink, GertjanDepartment of Rheumatology, Amsterdam Rheumatology and Immunology Center (ARC), Reade, Amsterdam, Netherlands (author)
van der Horst-Bruinsma, IreneDepartment of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location Vrije Universiteit, Amsterdam, Netherlands (author)
Cui, JingDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States (author)
Liao, Katherine P.Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, MA, Boston, United States (author)
Carroll, Robert J.Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States (author)
Lee, Hye-SoonDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Hanyang University Institute for Rheumatology Research, Seoul, South Korea (author)
Bang, So-YoungDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Hanyang University Institute for Rheumatology Research, Seoul, South Korea (author)
Siminovitch, Katherine A.Lunenfeld-Tanenbaum Research Institute, ON, Toronto, Canada; Departments of Medicine and Immunology, University of Toronto, ON, Toronto, Canada (author)
de Vries, NiekDepartment of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location AMC/University of Amsterdam, Amsterdam, Netherlands (author)
Alfredsson, LarsInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (author)
Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi(Swepub:umu)sora0001 (author)
Karlson, Elizabeth W.Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States (author)
Bae, Sang-CheolDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Hanyang University Institute for Rheumatology Research, Seoul, South Korea (author)
Kimberly, Robert P.Center for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL, Birmingham, United States (author)
Edberg, Jeffrey C.Center for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL, Birmingham, United States (author)
Mariette, XavierDepartment of Rheumatology, Université Paris-Saclay, Assistance Pubique - Hôpitaux de Paris, Hôpital Bicêtre, INSERM UMR1184, Le Kremlin Bicêtre, France (author)
Huizinga, TomLeiden University Medical Center, Leiden, Netherlands (author)
Dieudé, PhilippeUniversity of Paris Cité, Inserm, PHERE, F-75018, Paris, France; Department of Rheumatology, Hôpital Bichat, APHP, Paris, France (author)
Schneider, MatthiasDepartment of Rheumatology & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany (author)
Kerick, MartinInstitute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain (author)
Denny, Joshua C.Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States; All of Us Research Program, Office of the Director, National Institutes of Health, MD, Bethesda, United States; Department of Medicine, Vanderbilt University School of Medicine, TN, Nashville, United States (author)
Matsuda, KoichiLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan (author)
Matsuo, KeitaroDivision of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (author)
Mimori, TsuneyoDepartment of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan (author)
Matsuda, FumihikoCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (author)
Fujio, KeishiDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (author)
Tanaka, YoshiyaThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan (author)
Kumanogoh, AtsushiIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan; Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan (author)
Traylor, MatthewDepartment of Medical & Molecular Genetics, King’s College London, London, United Kingdom; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, United Kingdom; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom (author)
Lewis, Cathryn M.Department of Medical & Molecular Genetics, King’s College London, London, United Kingdom; Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, United Kingdom (author)
Eyre, StephenCentre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom (author)
Xu, HujiDepartment of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China; School of Clinical Medicine Tsinghua University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, China (author)
Saxena, RichaProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States (author)
Arayssi, ThurayyaDepartment of Internal Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar (author)
Kochi, YutaDepartment of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)
Ikari, KatsunoriInstitute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Department of Orthopedic Surgery, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan; Division of Multidisciplinary Management of Rheumatic Diseases, Tokyo Women’s Medical University, Tokyo, Japan (author)
Harigai, MasayoshiInstitute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan (author)
Gregersen, Peter K.Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, NY, Manhasset, United States (author)
Yamamoto, KazuhikoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan (author)
Louis Bridges, S.Department of Medicine, Hospital for Special Surgery, NY, New York, United States; Division of Rheumatology, Weill Cornell Medicine, NY, New York, United States (author)
Padyukov, LeonidDepartment of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden (author)
Martin, JavierInstitute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain (author)
Klareskog, LarsDepartment of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden (author)
Okada, YukinoriDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (author)
Raychaudhuri, SoumyaCenter for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States; Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom (author)
Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanCenter for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States (creator_code:org_t)

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By the author/editor: Ishigaki, Kazuyo ...; Sakaue, Saori; Terao, Chikashi; Luo, Yang; Sonehara, Kyuto; Yamaguchi, Kensu ...; show more...; Amariuta, Tiffan ...; Too, Chun Lai; Laufer, Vincent ...; Scott, Ian C.; Viatte, Sebastie ...; Takahashi, Meiko; Ohmura, Koichiro; Murasawa, Akira; Hashimoto, Motom ...; Ito, Hiromu; Hammoudeh, Moham ...; Emadi, Samar Al; Masri, Basel K.; Halabi, Hussein; Badsha, Humeira; Uthman, Imad W.; Wu, Xin; Lin, Li; Li, Ting; Plant, Darren; Barton, Anne; Orozco, Gisela; Verstappen, Suza ...; Bowes, John; MacGregor, Alexa ...; Honda, Suguru; Koido, Masaru; Tomizuka, Kohei; Kamatani, Yoichi ...; Tanaka, Hiroaki; Tanaka, Eiichi; Suzuki, Akari; Maeda, Yuichi; Yamamoto, Kenich ...; Miyawaki, Satoru; Xie, Gang; Zhang, Jinyi; Amos, Christophe ...; Keystone, Edward; Wolbink, Gertjan; van der Horst-Br ...; Cui, Jing; Liao, Katherine ...; Carroll, Robert ...; Lee, Hye-Soon; Bang, So-Young; Siminovitch, Kat ...; de Vries, Niek; Alfredsson, Lars; Rantapää-Dahlqvi ...; Karlson, Elizabe ...; Bae, Sang-Cheol; Kimberly, Robert ...; Edberg, Jeffrey ...; Mariette, Xavier; Huizinga, Tom; Dieudé, Philippe; Schneider, Matth ...; Kerick, Martin; Denny, Joshua C.; Matsuda, Koichi; Matsuo, Keitaro; Mimori, Tsuneyo; Matsuda, Fumihik ...; Fujio, Keishi; Tanaka, Yoshiya; Kumanogoh, Atsus ...; Traylor, Matthew; Lewis, Cathryn M ...; Eyre, Stephen; Xu, Huji; Saxena, Richa; Arayssi, Thurayy ...; Kochi, Yuta; Ikari, Katsunori; Harigai, Masayos ...; Gregersen, Peter ...; Yamamoto, Kazuhi ...; Louis Bridges, S ...; Padyukov, Leonid; Martin, Javier; Klareskog, Lars; Okada, Yukinori; Raychaudhuri, So ...; show less...

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