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Blood cell DNA meth...
Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma : the EPIC prospective cohort
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- Allione, Alessandra (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Viberti, Clara (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Cotellessa, Ilaria (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Catalano, Chiara (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Casalone, Elisabetta (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Cugliari, Giovanni (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Russo, Alessia (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy
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- Guarrera, Simonetta (författare)
- Candiolo Cancer Institute, FPO—IRCCS, Candiolo, Italy
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- Mirabelli, Dario (författare)
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates “G. Scansetti”, University of Turin, Turin, Italy
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- Sacerdote, Carlotta (författare)
- Unit of Cancer Epidemiology, Città Della Salute e Della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy
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- Gentile, Marco (författare)
- A.O.U. Federico II, Naples, Italy
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- Eichelmann, Fabian (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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- Eriksen, Anne Kirstine (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Andersson, Martin (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Dollé, Martijn E.T. (författare)
- Centre for Health Protection National Institute for Public Health and the Environment, Bilthoven, Netherlands
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- Van Puyvelde, Heleen (författare)
- International Agency for Research on Cancer, World Health Organisation, Lyon, France
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organisation, Lyon, France
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- Rodriguez-Barranco, Miguel (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Agudo, Antonio (författare)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology—ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group, Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute—IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
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- Heath, Alicia K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Chirlaque, María-Dolores (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
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- Truong, Thérèse (författare)
- Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France
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- Dragic, Dzevka (författare)
- Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France; Centre de Recherche sur le Cancer de l'Université Laval, Département de Médecine Sociale et Préventive, Faculté de Médecine, Québec, Canada; Axe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, Québec, Canada
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- Severi, Gianluca (författare)
- Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome, Heredity, Cancer and Health” Team, Paris, France; Department of Statistics, Computer Science and Applications “G. Parenti” (DISIA), University of Florence, Florence, Italy
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- Sieri, Sabina (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy
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- Sandanger, Torkjel M. (författare)
- Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
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- Ardanaz, Eva (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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- Vineis, Paolo (författare)
- MRC Centre for Environment and Health, Imperial College London, London, United Kingdom
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- Matullo, Giuseppe (författare)
- Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates “G. Scansetti”, University of Turin, Turin, Italy; Medical Genetics Unit, AOU Città della Salute e Della Scienza, Turin, Italy
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(creator_code:org_t)
- 2022-11-05
- 2023
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 152:4, s. 725-737
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer and nutrition (EPIC) cohort, aiming to characterise DNAm biomarkers associated with MPM. From the EPIC cohort, we included samples from 135 participants who developed MPM during 20 years of follow-up and from 135 matched, cancer-free, controls. For the discovery phase we selected EPIC participants who developed MPM within 5 years from enrolment (n = 36) with matched controls. We identified nine differentially methylated CpGs, selected by 10-fold cross-validation and correlation analyses: cg25755428 (MRI1), cg20389709 (KLF11), cg23870316, cg13862711 (LHX6), cg06417478 (HOOK2), cg00667948, cg01879420 (AMD1), cg25317025 (RPL17) and cg06205333 (RAP1A). Receiver operating characteristic (ROC) analysis showed that the model including baseline characteristics (age, sex and PC1wbc) along with the nine MPM-related CpGs has a better predictive value for MPM occurrence than the baseline model alone, maintaining some performance also at more than 5 years before diagnosis (area under the curve [AUC] < 5 years = 0.89; AUC 5-10 years = 0.80; AUC >10 years = 0.75; baseline AUC range = 0.63-0.67). DNAm changes as noninvasive biomarkers in prediagnostic blood samples of MPM cases were investigated for the first time. Their application can improve the identification of asbestos-exposed individuals at higher MPM risk to possibly adopt more intensive monitoring for early disease identification.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cancer biomarkers
- DNA methylation
- mesothelioma
- prospective nested case-control study
- Oncology
- onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Allione, Alessan ...
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Viberti, Clara
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Cotellessa, Ilar ...
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Catalano, Chiara
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Casalone, Elisab ...
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Cugliari, Giovan ...
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Russo, Alessia
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Guarrera, Simone ...
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Mirabelli, Dario
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Sacerdote, Carlo ...
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Gentile, Marco
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Eichelmann, Fabi ...
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Schulze, Matthia ...
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Harlid, Sophia, ...
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Eriksen, Anne Ki ...
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Tjønneland, Anne
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Andersson, Marti ...
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Dollé, Martijn E ...
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Van Puyvelde, He ...
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Weiderpass, Elis ...
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Rodriguez-Barran ...
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Agudo, Antonio
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Heath, Alicia K.
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Chirlaque, María ...
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Truong, Thérèse
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Dragic, Dzevka
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Severi, Gianluca
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Sieri, Sabina
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Sandanger, Torkj ...
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Ardanaz, Eva
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Vineis, Paolo
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Matullo, Giusepp ...
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