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Individual differen...
Individual differences in brain aging : heterogeneity in cortico-hippocampal but not caudate atrophy rates
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway
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- Andersson, Micael (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Lundquist, Anders, 1978- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik
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- Baaré, William F.C. (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
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- Bartrés-Faz, David (författare)
- Department of Medicine, Faculty of Medicine and Health Sciences, Institut de Neurociències, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
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- Bertram, Lars (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
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- Boraxbekk, Carl-Johan, 1980- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Faculty of Medical and Health Sciences, Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Neurology, Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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- Brandmaier, Andreas M. (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; MSB Medical School Berlin, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
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- Demnitz, Naiara (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
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- Drevon, Christian A. (författare)
- Vitas AS, Science Park, Oslo, Norway; Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Duezel, Sandra (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Ebmeier, Klaus P. (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Ghisletta, Paolo (författare)
- Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; UniDistance Suisse, Brig, Switzerland; Swiss National Centre of Competence in Research LIVES, University of Geneva, Geneva, Switzerland
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- Henson, Richard (författare)
- Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, University of Cambridge, Cambridge, England
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- Jensen, Daria E.A. (författare)
- 5Department of Psychiatry, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK
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- Kievit, Rogier A. (författare)
- Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
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- Knights, Ethan (författare)
- Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, University of Cambridge, Cambridge, England
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- Kühn, Simone (författare)
- Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
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- Lindenberger, Ulman (författare)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
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- Plachti, Anna (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
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- Pudas, Sara, Docent, 1983- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Roe, James M. (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway,
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- Madsen, Kathrine Skak (författare)
- Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK
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- Solé-Padullés, Cristina (författare)
- Department of Medicine, Faculty of Medicine and Health Sciences, Institut de Neurociències, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
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- Sommerer, Yasmine (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
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- Suri, Sana (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK; 1Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
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- Zsoldos, Enikő (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK; 1Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
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- Fjell, Anders M. (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway; Center for Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway
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- Walhovd, Kristine B. (författare)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, Oslo, Norway; Center for Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway
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(creator_code:org_t)
- 2022-10-05
- 2023
- Engelska.
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Ingår i: Cerebral Cortex. - : Oxford University Press. - 1047-3211 .- 1460-2199. ; 33:9, s. 5075-5081
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- aging
- individual differences
- caudate
- hippocampus
- cortex
- Medicine
- medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Nyberg, Lars, 19 ...
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Andersson, Micae ...
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Lundquist, Ander ...
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Baaré, William F ...
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Bartrés-Faz, Dav ...
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Bertram, Lars
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Boraxbekk, Carl- ...
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Brandmaier, Andr ...
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Demnitz, Naiara
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Drevon, Christia ...
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Duezel, Sandra
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Ebmeier, Klaus P ...
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Ghisletta, Paolo
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Henson, Richard
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Jensen, Daria E. ...
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Kievit, Rogier A ...
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Knights, Ethan
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Kühn, Simone
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Lindenberger, Ul ...
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Plachti, Anna
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Pudas, Sara, Doc ...
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Roe, James M.
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Madsen, Kathrine ...
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Solé-Padullés, C ...
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Sommerer, Yasmin ...
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Suri, Sana
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Zsoldos, Enikő
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Fjell, Anders M.
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Walhovd, Kristin ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Cerebral Cortex
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Umeå universitet