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Sökning: WFRF:(Sandanger Torkjel) > (2023) > Increased levels of...

Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer

Nøst, Therese Haugdahl (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Skogholt, Anne Heidi (författare)
Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Urbarova, Ilona (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
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Mjelle, Robin (författare)
Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Bioinformatics Core Facility, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
Paulsen, Erna-Elise (författare)
Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Pulmonology, University Hospital of North Norway, Tromsø, Norway
Dønnem, Tom (författare)
Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Oncology, University Hospital of North Norway, Tromsø, Norway
Andersen, Sigve (författare)
Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Oncology, University Hospital of North Norway, Tromsø, Norway
Markaki, Maria (författare)
Institute of Computer Science, Crete, Greece
Røe, Oluf Dimitri (författare)
Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Cancer Clinic, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway
Johansson, Mikael (författare)
Umeå universitet,Onkologi
Johansson, Mattias (författare)
International Agency for Research on Cancer, Lyon, France
Grønberg, Bjørn Henning (författare)
Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Oncology, St. Olavs Hospital, Trondheim University Hospital, Norway
Sandanger, Torkjel Manning (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Sætrom, Pål (författare)
Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Bioinformatics Core Facility, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Computer Science, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Public Health and Nursing, KG. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway (creator_code:org_t)
2022-11-27
2023
Engelska.
Ingår i: Molecular Oncology. - : John Wiley & Sons. - 1574-7891 .- 1878-0261. ; 17:2, s. 312-327
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes in such candidate miRNAs could be detected. We identified upregulated candidate miRNAs in plasma specimens from a hospital-based study sample of 128 patients with confirmed LC and 62 individuals with suspected but confirmed negative LC (FalsePos). We then evaluated the expression of candidate miRNAs in pre-diagnostic plasma or serum specimens of 360 future LC cases and 375 matched controls. There were 1663 miRNAs detected in diagnostic specimens, nine of which met our criteria for candidate miRNAs. Higher expression of three candidates, miR-320b, 320c, and 320d, was associated with poor survival, independent of LC stage and subtype. Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Nyckelord

diagnostic markers
lung cancer
MiRNA
peripheral blood
pre-diagnostic markers

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