Sökning: WFRF:(Sandanger Torkjel) >
Increased levels of...
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
-
- Nøst, Therese Haugdahl (författare)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
-
- Skogholt, Anne Heidi (författare)
- Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
-
- Urbarova, Ilona (författare)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
-
visa fler...
-
- Mjelle, Robin (författare)
- Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Bioinformatics Core Facility, NTNU – Norwegian University of Science and Technology, Trondheim, Norway
-
- Paulsen, Erna-Elise (författare)
- Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Pulmonology, University Hospital of North Norway, Tromsø, Norway
-
- Dønnem, Tom (författare)
- Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Oncology, University Hospital of North Norway, Tromsø, Norway
-
- Andersen, Sigve (författare)
- Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Oncology, University Hospital of North Norway, Tromsø, Norway
-
- Markaki, Maria (författare)
- Institute of Computer Science, Crete, Greece
-
- Røe, Oluf Dimitri (författare)
- Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Cancer Clinic, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway
-
- Johansson, Mikael (författare)
- Umeå universitet,Onkologi
-
- Johansson, Mattias (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Grønberg, Bjørn Henning (författare)
- Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Oncology, St. Olavs Hospital, Trondheim University Hospital, Norway
-
- Sandanger, Torkjel Manning (författare)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
-
- Sætrom, Pål (författare)
- Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Bioinformatics Core Facility, NTNU – Norwegian University of Science and Technology, Trondheim, Norway; Department of Computer Science, Norwegian University of Science and Technology, Trondheim, Norway
-
visa färre...
-
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; Department of Public Health and Nursing, KG. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU – Norwegian University of Science and Technology, Trondheim, Norway (creator_code:org_t)
- 2022-11-27
- 2023
- Engelska.
-
Ingår i: Molecular Oncology. - : John Wiley & Sons. - 1574-7891 .- 1878-0261. ; 17:2, s. 312-327
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes in such candidate miRNAs could be detected. We identified upregulated candidate miRNAs in plasma specimens from a hospital-based study sample of 128 patients with confirmed LC and 62 individuals with suspected but confirmed negative LC (FalsePos). We then evaluated the expression of candidate miRNAs in pre-diagnostic plasma or serum specimens of 360 future LC cases and 375 matched controls. There were 1663 miRNAs detected in diagnostic specimens, nine of which met our criteria for candidate miRNAs. Higher expression of three candidates, miR-320b, 320c, and 320d, was associated with poor survival, independent of LC stage and subtype. Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- diagnostic markers
- lung cancer
- MiRNA
- peripheral blood
- pre-diagnostic markers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nøst, Therese Ha ...
-
Skogholt, Anne H ...
-
Urbarova, Ilona
-
Mjelle, Robin
-
Paulsen, Erna-El ...
-
Dønnem, Tom
-
visa fler...
-
Andersen, Sigve
-
Markaki, Maria
-
Røe, Oluf Dimitr ...
-
Johansson, Mikae ...
-
Johansson, Matti ...
-
Grønberg, Bjørn ...
-
Sandanger, Torkj ...
-
Sætrom, Pål
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Klinisk laborato ...
- Artiklar i publikationen
-
Molecular Oncolo ...
- Av lärosätet
-
Umeå universitet