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Deciphering colorec...
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
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- Fernandez-Rozadilla, Ceres (author)
- Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Genomic Medicine Group, Instituto de Investigacion Sanitaria de Santiago, Santiago de Compostela, Spain
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- Timofeeva, Maria (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark
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- Chen, Zhishan (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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- Law, Philip (author)
- Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
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- Thomas, Minta (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Schmit, Stephanie (author)
- Karolinska Institutet
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- Díez-Obrero, Virginia (author)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Hsu, Li (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States
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- Fernandez-Tajes, Juan (author)
- Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Palles, Claire (author)
- Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
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- Sherwood, Kitty (author)
- Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Briggs, Sarah (author)
- Department of Public Health, Richard Doll Building, University of Oxford, Oxford, United Kingdom
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- Svinti, Victoria (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Donnelly, Kevin (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Farrington, Susan (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Blackmur, James (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Vaughan-Shaw, Peter (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
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- Shu, Xiao-ou (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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- Long, Jirong (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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- Cai, Qiuyin (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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- Guo, Xingyi (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States; Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States
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- Lu, Yingchang (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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- Broderick, Peter (author)
- Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
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- Studd, James (author)
- Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
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- Huyghe, Jeroen (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Harrison, Tabitha (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Conti, David (author)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Dampier, Christopher (author)
- Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
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- Devall, Mathew (author)
- Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
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- Schumacher, Fredrick (author)
- Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States; Case Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States
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- Melas, Marilena (author)
- The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital, OH, Columbus, United States
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- Rennert, Gad (author)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Obón-Santacana, Mireia (author)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain
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- Martín-Sánchez, Vicente (author)
- Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Biomedicine Institute, University of León, León, Spain
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- Moratalla-Navarro, Ferran (author)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Oh, Jae Hwan (author)
- Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea
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- Kim, Jeongseon (author)
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea
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- Jee, Sun Ha (author)
- Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea
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- Jung, Keum Ji (author)
- Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea
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- Kweon, Sun-Seog (author)
- Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
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- Shin, Min-Ho (author)
- Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
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- Shin, Aesun (author)
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea; Cancer Research Institute, Seoul National University, Seoul, South Korea
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- Ahn, Yoon-Ok (author)
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
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- Kim, Dong-Hyun (author)
- Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea
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- Oze, Isao (author)
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
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- Wen, Wanqing (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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- Matsuo, Keitaro (author)
- Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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- Matsuda, Koichi (author)
- Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
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- Tanikawa, Chizu (author)
- Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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- Ren, Zefang (author)
- School of Public Health, Sun Yat-sen University, Guangzhou, China
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- Gao, Yu-Tang (author)
- State Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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- Jia, Wei-Hua (author)
- State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China
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- Hopper, John (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
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- Jenkins, Mark (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
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- Win, Aung Ko (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
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- Pai, Rish (author)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
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- Figueiredo, Jane (author)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
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- Haile, Robert (author)
- Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, CA, Los Angeles, United States
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- Gallinger, Steven (author)
- Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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- Woods, Michael (author)
- Division of Biomedical Sciences, Memorial University of Newfoundland, ON, St. John, Canada
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- Newcomb, Polly (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
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- Duggan, David (author)
- City of Hope National Medical Center, Translational Genomics Research Institute, AZ, Phoenix, United States
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- Cheadle, Jeremy (author)
- Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom
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- Kaplan, Richard (author)
- MRC Clinical Trials Unit, Medical Research Council, Cardiff, United Kingdom
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- Maughan, Timothy (author)
- MRC Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom
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- Kerr, Rachel (author)
- Department of Oncology, University of Oxford, Oxford, United Kingdom
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- Kerr, David (author)
- Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
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- Kirac, Iva (author)
- Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
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- Böhm, Jan (author)
- Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland
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- Mecklin, Lukka-Pekka (author)
- Central Finland Health Care District, Jyväskylä, Finland
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- Jousilahti, Pekka (author)
- Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Knekt, Paul (author)
- Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Aaltonen, Lauri (author)
- Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
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- Rissanen, Harri (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Pukkala, Eero (author)
- Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; Faculty of Social Sciences, Tampere University, Tampere, Finland
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- Eriksson, Johan (author)
- Folkhälsan Research Centre, University of Helsinki, Helsinki, Finland; Human Potential Translational Research Programme, National University of Singapore, Singapore, Singapore; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Cajuso, Tatiana (author)
- Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
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- Hänninen, Ulrika (author)
- Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
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- Kondelin, Johanna (author)
- Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
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- Palin, Kimmo (author)
- Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
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- Tanskanen, Tomas (author)
- Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
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- Renkonen-Sinisalo, Laura (author)
- Department of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland
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- Zanke, Brent (author)
- Department of Oncology, University of Toronto, ON, Toronto, Canada
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- Männistö, Satu (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Albanes, Demetrius (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Weinstein, Stephanie (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Ruiz-Narvaez, Edward (author)
- Department of Nutritional Sciences, School of Public Health, University of Michigan, MI, Ann Arbor, United States
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- Palmer, Julie (author)
- Slone Epidemiology Center at Boston University, MA, Boston, United States; Department of Medicine, Boston University School of Medicine, MA, Boston, United States
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- Buchanan, Daniel (author)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
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- Platz, Elizabeth (author)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Visvanathan, Kala (author)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Ulrich, Cornelia (author)
- Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Siegel, Erin (author)
- Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
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- Brezina, Stefanie (author)
- Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
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- Gsur, Andrea (author)
- Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
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- Campbell, Peter (author)
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, New York, United States
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- Chang-Claude, Jenny (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany
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- Hoffmeister, Michael (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
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- Brenner, Hermann (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany
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- Slattery, Martha (author)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Potter, John (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
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- Tsilidis, Konstantinos (author)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Schulze, Matthias (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Gunter, Marc (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Murphy, Neil (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Castells, Antoni (author)
- Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
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- Castellví-Bel, Sergi (author)
- Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
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- Moreira, Leticia (author)
- Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
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- Arndt, Volker (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
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- Shcherbina, Anna (author)
- Department of Genetics, Stanford University, CA, Stanford, United States
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- Stern, Mariana (author)
- Department of Population and Public Health Sciences, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
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- Pardamean, Bens (author)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Bishop, Timothy (author)
- Leeds Institute of Medical Research at St James’s, University of Leeds, Leeds, United Kingdom
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- Giles, Graham (author)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Southey, Melissa (author)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia; Department of Clinical Pathology, University of Melbourne, VIC, Melbourne, Australia
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- Idos, Gregory (author)
- Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
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- McDonnell, Kevin (author)
- Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
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- Abu-Ful, Zomoroda (author)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
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- Greenson, Joel (author)
- Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Department of Pathology, University of Michigan, MI, Ann Arbor, United States
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- Shulman, Katerina (author)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
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- Lejbkowicz, Flavio (author)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel
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- Offit, Kenneth (author)
- Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States
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- Su, Yu-Ru (author)
- Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
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- Steinfelder, Robert (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Keku, Temitope (author)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
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- van Guelpen, Bethany (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Hudson, Thomas (author)
- Ontario Institute for Cancer Research, ON, Toronto, Canada
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- Hampel, Heather (author)
- Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
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- Pearlman, Rachel (author)
- Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
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- Berndt, Sonja (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Hayes, Richard (author)
- Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States
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- Martinez, Marie Elena (author)
- Population Sciences, Disparities and Community Engagement, University of California San Diego Moores Cancer Center, La Jolla, CA, United States; Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, United States
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- Thomas, Sushma (author)
- Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Corley, Douglas (author)
- Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Gastroenterology, Kaiser Permanente Medical Center, CA, San Francisco, United States
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- Pharoah, Paul (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Larsson, Susanna (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Yen, Yun (author)
- Taipei Medical University, Taipei, Taiwan
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- Lenz, Heinz-Josef (author)
- Department of Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- White, Emily (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Li, Li (author)
- Case Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States
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- Doheny, Kimberly (author)
- Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
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- Pugh, Elizabeth (author)
- Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
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- Shelford, Tameka (author)
- Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
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- Chan, Andrew (author)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Cruz-Correa, Marcia (author)
- Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico
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- Lindblom, Annika (author)
- Karolinska Institutet
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- Hunter, David (author)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Joshi, Amit (author)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Schafmayer, Clemens (author)
- Department of General Surgery, University Hospital Rostock, Rostock, Germany
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- Scacheri, Peter (author)
- Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
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- Kundaje, Anshul (author)
- Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
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- Nickerson, Deborah (author)
- Department of Genome Sciences, University of Washington, WA, Seattle, United States
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- Schoen, Robert (author)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Hampe, Jochen (author)
- Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany
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- Stadler, Zsofia (author)
- Department of Medicine, Weill Cornell Medical College, NY, New York, United States; Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, New York, United States
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- Vodicka, Pavel (author)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Vodickova, Ludmila (author)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Vymetalkova, Veronika (author)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Papadopoulos, Nickolas (author)
- Department of Oncology Ludwig Center at the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, MD, Baltimore, United States; Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, MD, Baltimore, United States; Department of Pathology, Johns Hopkins School of Medicine, MD, Baltimore, United States
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- Edlund, Chistopher (author)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Gauderman, William (author)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Thomas, Duncan (author)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Shibata, David (author)
- Department of Surgery, University of Tennessee Health Science Center, TN, Memphis, United States
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- Toland, Amanda (author)
- Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, OH, Columbus, United States
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- Markowitz, Sanford (author)
- Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH, Cleveland, United States
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- Kim, Andre (author)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Chanock, Stephen (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- van Duijnhoven, Franzel (author)
- Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands
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- Feskens, Edith (author)
- Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands
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- Sakoda, Lori (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Gago-Dominguez, Manuela (author)
- Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain
-
- Wolk, Alicja (author)
- Karolinska Institutet
-
- Naccarati, Alessio (author)
- Italian Institute for Genomic Medicine, Candiolo Cancer Institute, Turin, Italy; Candiolo Cancer Institute, Candiolo, Italy
-
- Pardini, Barbara (author)
- Italian Institute for Genomic Medicine, Candiolo Cancer Institute, Turin, Italy; Candiolo Cancer Institute, Candiolo, Italy
-
- FitzGerald, Liesel (author)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, TAS, Hobart, Australia
-
- Lee, Soo Chin (author)
- National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
-
- Ogino, Shuji (author)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
-
- Bien, Stephanie (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
-
- Kooperberg, Charles (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
-
- Li, Christopher (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
-
- Lin, Yi (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
-
- Prentice, Ross (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
-
- Qu, Conghui (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
-
- Bézieau, Stéphane (author)
- Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France
-
- Tangen, Catherine (author)
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
-
- Mardis, Elaine (author)
- Department of Pediatrics, Nationwide Children’s Hospital, The Steve and Cindy Rasmussen Institute for Genomic Medicine, OH, Columbus, United States
-
- Yamaji, Taiki (author)
- Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
-
- Sawada, Norie (author)
- Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
-
- Iwasaki, Motoki (author)
- Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
-
- Haiman, Christopher (author)
- Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, CA, Los Angeles, United States
-
- Le Marchand, Loic (author)
- Cancer Center, University of Hawaii, HI, Honolulu, United States
-
- Wu, Anna (author)
- Preventative Medicine, University of Southern California, CA, Los Angeles, United States
-
- Qu, Chenxu (author)
- USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
-
- McNeil, Caroline (author)
- USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
-
- Coetzee, Gerhard (author)
- Van Andel Research Institute, MI, Grand Rapids, United States
-
- Hayward, Caroline (author)
- MRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
-
- Deary, Ian (author)
- Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
-
- Harris, Sarah (author)
- Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
-
- Theodoratou, Evropi (author)
- Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom
-
- Reid, Stuart (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
-
- Walker, Marion (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
-
- Ooi, Li Yin (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore
-
- Moreno, Victor (author)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
-
- Casey, Graham (author)
- Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
-
- Gruber, Stephen (author)
- Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
-
- Tomlinson, Ian (author)
- Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
-
- Zheng, Wei (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
-
- Dunlop, Malcolm (author)
- Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
-
- Houlston, Richard (author)
- Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
-
- Peters, Ulrike (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
-
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-
(creator_code:org_t)
- 2022-12-20
- 2023
- English.
-
In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 55, s. 89-99
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Nature Genetics
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Umeå University
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Karolinska Institutet