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Circulating vitamin...
Circulating vitamin D and breast cancer risk : an international pooling project of 17 cohorts
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- Visvanathan, Kala (författare)
- Departments of Epidemiology and Oncology, Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Center, MD, Baltimore, United States
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- Mondul, Alison M. (författare)
- Department of Epidemiology, University of Michigan School of Public Health, MI, Ann Arbor, United States
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- Zeleniuch-Jacquotte, Anne (författare)
- Departments of Population Health and Environmental Medicine, New York University Grossman School of Medicine, NY, New York, United States
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visa fler...
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- Wang, Molin (författare)
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, MA, Boston, United States
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- Gail, Mitchell H. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Yaun, Shiaw-Shyuan (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Weinstein, Stephanie J. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- McCullough, Marjorie L. (författare)
- Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Eliassen, A. Heather (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Cook, Nancy R. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States
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- Agnoli, Claudia (författare)
- Epidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy
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- Almquist, Martin (författare)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Black, Amanda (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Buring, Julie E. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States
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- Chen, Chu (författare)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Chen, Yu (författare)
- Departments of Population Health and Environmental Medicine, New York University Grossman School of Medicine, NY, New York, United States
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- Clendenen, Tess (författare)
- Departments of Population Health and Environmental Medicine, New York University Grossman School of Medicine, NY, New York, United States
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- Dossus, Laure (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Fedirko, Veronika (författare)
- Department of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, GA, Atlanta, United States
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- Gierach, Gretchen L. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Giovannucci, Edward L. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Goodman, Gary E. (författare)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Goodman, Marc T. (författare)
- Cancer Prevention and Control Research Program, Cedars Sinai Samuel Oschin Comprehensive Cancer Institute, CA, Los Angeles, United States
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- Guénel, Pascal (författare)
- Center for Research in Epidemiology and Population Health (CESP), French National Institute of Health and Medical Research (INSERM), University Paris-Saclay, Villejuif, France
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Hankinson, Susan E. (författare)
- Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, MA, Amherst, United States
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- Horst, Ronald L. (författare)
- Heartland Assays, LLC, IA, Ames, United States
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- Hou, Tao (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Huang, Wen-Yi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Jones, Michael E. (författare)
- Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
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- Joshu, Corrine E. (författare)
- Departments of Epidemiology and Oncology, Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Center, MD, Baltimore, United States
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Krogh, Vittorio (författare)
- Epidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy
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- Kühn, Tilman (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute for Global Food Security, Queen’s University, Belfast, United Kingdom
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- Kvaskoff, Marina (författare)
- Center for Research in Epidemiology and Population Health (CESP), French National Institute of Health and Medical Research (INSERM), University Paris-Saclay, Villejuif, France
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- Lee, I-Min (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States
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- Mahamat-Saleh, Yahya (författare)
- Center for Research in Epidemiology and Population Health (CESP), French National Institute of Health and Medical Research (INSERM), University Paris-Saclay, Villejuif, France
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- Malm, J. (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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- Manjer, J. (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Maskarinec, Gertraud (författare)
- Cancer Epidemiology Program, University of Hawai’i Cancer Center, HI, Honolulu, United States
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- Millen, Amy E. (författare)
- Department of Epidemiology and Environmental Health, University at Buffalo, NY, Buffalo, United States
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- Mukhtar, Toqir K. (författare)
- Department of Primary Care and Public Health, Imperial College, London, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Neuhouser, Marian L. (författare)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Robsahm, Trude E. (författare)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway
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- Schoemaker, Minouk J. (författare)
- Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
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- Sieri, Sabina (författare)
- Epidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy
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- Sund, Malin (författare)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Swerdlow, Anthony J. (författare)
- Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom
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- Thomson, Cynthia A. (författare)
- Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona and University of Arizona Cancer Center, AZ, Tucson, United States
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- Ursin, Giske (författare)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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- Wactawski-Wende, Jean (författare)
- Department of Epidemiology and Environmental Health, University at Buffalo, NY, Buffalo, United States
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- Wang, Ying (författare)
- Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Wilkens, Lynne R. (författare)
- Population Sciences in the Pacific, University of Hawai’i Cancer Center, HI, Honolulu, United States
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- Wu, Yujie (författare)
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Zoltick, Emilie (författare)
- Department of Population Medicine, Harvard Medical School, MA, Boston, United States
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- Willett, Walter C. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Smith-Warner, Stephanie A. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Ziegler, Regina G. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,National Cancer Institute, NCI
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(creator_code:org_t)
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et al
- 2023-01-03
- 2023
- Engelska.
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Ingår i: European Journal of Epidemiology. - : Springer Science+Business Media B.V.. - 0393-2990 .- 1573-7284. ; 38, s. 11-29
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42–68) years at blood collection and 63 (49–75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, calibrated to this assay to permit using a common metric. Study-specific relative risks (RRs) for season-standardized 25(OH)D concentrations were estimated by conditional logistic regression and combined by random-effects models. Circulating 25(OH)D increased from a median of 22.6 nmol/L in consortium-wide decile 1 to 93.2 nmol/L in decile 10. Breast cancer risk in each decile was not statistically significantly different from risk in decile 5 in models adjusted for breast cancer risk factors, and no trend was apparent (P-trend = 0.64). Compared to women with sufficient 25(OH)D based on Institute of Medicine guidelines (50– < 62.5 nmol/L), RRs were not statistically significantly different at either low concentrations (< 20 nmol/L, 3% of controls) or high concentrations (100– < 125 nmol/L, 3% of controls; ≥ 125 nmol/L, 0.7% of controls). RR per 25 nmol/L increase in 25(OH)D was 0.99 [95% confidence intervaI (CI) 0.95–1.03]. Associations remained null across subgroups, including those defined by body mass index, physical activity, latitude, and season of blood collection. Although none of the associations by tumor characteristics reached statistical significance, suggestive inverse associations were seen for distant and triple negative tumors. Circulating 25(OH)D, comparably measured in 17 international cohorts and season-standardized, was not related to subsequent incidence of invasive breast cancer over a broad range in vitamin D status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- 25-Hydroxyvitamin D
- Biomarker
- Breast cancer
- Calibration
- Pooled analysis
- Prospective cohort study
- Vitamin D
- 25-Hydroxyvitamin D
- Biomarker
- Breast cancer
- Calibration
- Pooled analysis
- Prospective cohort study
- Vitamin D
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Visvanathan, Kal ...
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Mondul, Alison M ...
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Zeleniuch-Jacquo ...
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Wang, Molin
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Gail, Mitchell H ...
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Yaun, Shiaw-Shyu ...
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visa fler...
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Weinstein, Steph ...
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McCullough, Marj ...
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Eliassen, A. Hea ...
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Cook, Nancy R.
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Agnoli, Claudia
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Almquist, Martin
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Black, Amanda
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Buring, Julie E.
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Chen, Chu
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Chen, Yu
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Clendenen, Tess
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Dossus, Laure
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Fedirko, Veronik ...
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Gierach, Gretche ...
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Giovannucci, Edw ...
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Goodman, Gary E.
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Goodman, Marc T.
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Guénel, Pascal
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Hallmans, Göran, ...
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Hankinson, Susan ...
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Horst, Ronald L.
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Hou, Tao
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Huang, Wen-Yi
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Jones, Michael E ...
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Joshu, Corrine E ...
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Kaaks, Rudolf
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Krogh, Vittorio
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Kühn, Tilman
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Kvaskoff, Marina
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Lee, I-Min
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Mahamat-Saleh, Y ...
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Malm, J.
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Manjer, J.
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Maskarinec, Gert ...
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Millen, Amy E.
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Mukhtar, Toqir K ...
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Neuhouser, Maria ...
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Robsahm, Trude E ...
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Schoemaker, Mino ...
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Sieri, Sabina
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Sund, Malin
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Swerdlow, Anthon ...
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Thomson, Cynthia ...
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Ursin, Giske
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Wactawski-Wende, ...
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Wang, Ying
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Wilkens, Lynne R ...
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Wu, Yujie
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Zoltick, Emilie
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Willett, Walter ...
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Smith-Warner, St ...
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Ziegler, Regina ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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European Journal ...
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Umeå universitet
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