Mild-to-moderate kidney dysfunction and cardiovascular disease: Observational and mendelian randomization analyses

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MARC

Gaziano, LiamUniversity of Cambridge,Boston Veteran's Administration (VA) Healthcare (author)

Mild-to-moderate kidney dysfunction and cardiovascular disease : Observational and mendelian randomization analyses

Article/chapterEnglish2022

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Wolters Kluwer,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-202685
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202685URI
https://doi.org/10.1161/CIRCULATIONAHA.122.060700DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:du-43152URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491433URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:151504883URI
https://lup.lub.lu.se/record/5fe19d8e-bc8b-4d5a-9289-bad257428518URI
https://gup.ub.gu.se/publication/319719URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD.CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
cardiovascular diseases
coronary disease
kidney diseases
stroke
cardiovascular diseases
coronary disease
kidney diseases
stroke

Added entries (persons, corporate bodies, meetings, titles ...)

Sun, Luanluan (author)
Arnold, Matthew (author)
Bell, Steven (author)
Cho, Kelly (author)
Kaptoge, Stephen K. (author)
Song, Rebecca J. (author)
Burgess, Stephen (author)
Posner, Daniel C. (author)
Mosconi, Katja (author)
Robinson-Cohen, Cassianne (author)
Mason, Amy M. (author)
Bolton, Thomas R. (author)
Tao, Ran (author)
Allara, Elias (author)
Schubert, Petra (author)
Chen, Lingyan (author)
Staley, James R. (author)
Staplin, Natalie (author)
Altay, Servet (author)
Amiano, Pilar (author)
Arndt, Volker (author)
Ärnlöv, Johan,1970-Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap(Swepub:du)jan (author)
Barr, Elizabeth L. M. (author)
Björkelund, Cecilia (author)
Boer, Jolanda M. A. (author)
Brenner, Hermann (author)
Casiglia, Edoardo (author)
Chiodini, Paolo (author)
Cooper, Jackie A. (author)
Coresh, Josef (author)
Cushman, Mary (author)
Dankner, Rachel (author)
Davidson, Karina W. (author)
de Jongh, Renate T. (author)
Donfrancesco, Chiara (author)
Engström, G.Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
Freisling, Heinz (author)
de la Cámara, Agustín Gómez (author)
Gudnason, Vilmundur (author)
Hankey, Graeme J. (author)
Hansson, Per-Olof,1958Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xhanpm (author)
Heath, Alicia K. (author)
Hoorn, Ewout J. (author)
Imano, Hironori (author)
Jassal, Simerjot K. (author)
Kaaks, Rudolf (author)
Katzke, Verena (author)
Kauhanen, Jussi (author)
Kiechl, Stefan (author)
Koenig, Wolfgang (author)
Kronmal, Richard A. (author)
Kyrø, Cecilie (author)
Lawlor, Deborah A. (author)
Ljungberg, Börje,Professor,1949-Umeå universitet,Urologi och andrologi(Swepub:umu)bolj0001 (author)
MacDonald, Conor (author)
Masala, Giovanna (author)
Meisinger, Christa (author)
Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Moreno Iribas, Conchi (author)
Ninomiya, Toshiharu (author)
Nitsch, Dorothea (author)
Nordestgaard, Børge G. (author)
Onland-Moret, Charlotte (author)
Palmieri, Luigi (author)
Petrova, Dafina (author)
Garcia, Jose Ramón Quirós (author)
Rosengren, Annika,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xrosan (author)
Sacerdote, Carlotta (author)
Sakurai, Masaru (author)
Santiuste, Carmen (author)
Schulze, Matthias B. (author)
Sieri, Sabina (author)
Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi(Swepub:uu)johasund (author)
Tikhonoff, Valérie (author)
Tjønneland, Anne (author)
Tong, Tammy (author)
Tumino, Rosario (author)
Tzoulaki, Ioanna (author)
van der Schouw, Yvonne T. (author)
Monique Verschuren, W. M. (author)
Völzke, Henry (author)
Wallace, Robert B. (author)
Wannamethee, S. Goya (author)
Weiderpass, Elisabete (author)
Willeit, Peter (author)
Woodward, Mark (author)
Yamagishi, Kazumasa (author)
Zamora-Ros, Raul (author)
Akwo, Elvis A. (author)
Pyarajan, Saiju (author)
Gagnon, David R. (author)
Tsao, Philip S. (author)
Muralidhar, Sumitra (author)
Edwards, Todd L. (author)
Damrauer, Scott M. (author)
Joseph, Jacob (author)
Pennells, Lisa (author)
Wilson, Peter W. F. (author)
Harrison, Seamus (author)
Gaziano, Thomas A. (author)
Inouye, Michael (author)
Baigent, Colin (author)
Casas, Juan P. (author)
Langenberg, Claudia (author)
Wareham, Nick (author)
Riboli, Elio (author)
Gaziano, J. Michael (author)
Danesh, John (author)
Hung, Adriana M. (author)
Butterworth, Adam S. (author)
Wood, Angela M. (author)
Di Angelantonio, EmanueleHuman Technopole,University of Cambridge (author)
OnlandMoret, C (author)
ZamoraRos, R (author)
University of CambridgeBoston Veteran's Administration (VA) Healthcare (creator_code:org_t)
Emerging Risk Factors Collaboration
The Million Veteran Program
et al.

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In:Circulation: Wolters Kluwer146:20, s. 1507-15170009-73221524-4539

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By the author/editor: Gaziano, Liam; Sun, Luanluan; Arnold, Matthew; Bell, Steven; Cho, Kelly; Kaptoge, Stephen ...; show more...; Song, Rebecca J.; Burgess, Stephen; Posner, Daniel C ...; Mosconi, Katja; Robinson-Cohen, ...; Mason, Amy M.; Bolton, Thomas R ...; Tao, Ran; Allara, Elias; Schubert, Petra; Chen, Lingyan; Staley, James R.; Staplin, Natalie; Altay, Servet; Amiano, Pilar; Arndt, Volker; Ärnlöv, Johan, 1 ...; Barr, Elizabeth ...; Björkelund, Ceci ...; Boer, Jolanda M. ...; Brenner, Hermann; Casiglia, Edoard ...; Chiodini, Paolo; Cooper, Jackie A ...; Coresh, Josef; Cushman, Mary; Dankner, Rachel; Davidson, Karina ...; de Jongh, Renate ...; Donfrancesco, Ch ...; Engström, G.; Freisling, Heinz; de la Cámara, Ag ...; Gudnason, Vilmun ...; Hankey, Graeme J ...; Hansson, Per-Olo ...; Heath, Alicia K.; Hoorn, Ewout J.; Imano, Hironori; Jassal, Simerjot ...; Kaaks, Rudolf; Katzke, Verena; Kauhanen, Jussi; Kiechl, Stefan; Koenig, Wolfgang; Kronmal, Richard ...; Kyrø, Cecilie; Lawlor, Deborah ...; Ljungberg, Börje ...; MacDonald, Conor; Masala, Giovanna; Meisinger, Chris ...; Melander, O.; Moreno Iribas, C ...; Ninomiya, Toshih ...; Nitsch, Dorothea; Nordestgaard, Bø ...; Onland-Moret, Ch ...; Palmieri, Luigi; Petrova, Dafina; Garcia, Jose Ram ...; Rosengren, Annik ...; Sacerdote, Carlo ...; Sakurai, Masaru; Santiuste, Carme ...; Schulze, Matthia ...; Sieri, Sabina; Sundström, Johan ...; Tikhonoff, Valér ...; Tjønneland, Anne; Tong, Tammy; Tumino, Rosario; Tzoulaki, Ioanna; van der Schouw, ...; Monique Verschur ...; Völzke, Henry; Wallace, Robert ...; Wannamethee, S. ...; Weiderpass, Elis ...; Willeit, Peter; Woodward, Mark; Yamagishi, Kazum ...; Zamora-Ros, Raul; Akwo, Elvis A.; Pyarajan, Saiju; Gagnon, David R.; Tsao, Philip S.; Muralidhar, Sumi ...; Edwards, Todd L.; Damrauer, Scott ...; Joseph, Jacob; Pennells, Lisa; Wilson, Peter W. ...; Harrison, Seamus; Gaziano, Thomas ...; Inouye, Michael; Baigent, Colin; Casas, Juan P.; Langenberg, Clau ...; Wareham, Nick; Riboli, Elio; Gaziano, J. Mich ...; Danesh, John; Hung, Adriana M.; Butterworth, Ada ...; Wood, Angela M.; Di Angelantonio, ...; OnlandMoret, C; ZamoraRos, R; show less...

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