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  • Kolijn, P. MartijnDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands; Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands,Erasmus University Medical Center (författare)

High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • American Society of Hematology,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-203104
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203104URI
  • https://doi.org/10.1182/blood.2021012890DOI
  • https://lup.lub.lu.se/record/6cb41925-1539-4831-a356-513711367d04URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely unknown. In this study, we sequenced the B-cell receptor (BcR) immunoglobulin heavy chain (IGH) gene repertoire of 124 patients with CLL and 118 matched controls in blood samples taken up to 22 years prior to diagnosis. Significant skewing in the BcR IGH gene repertoire was detected in the majority of patients, even before the occurrence of lymphocytosis and irrespective of the clonotypic IGH variable gene somatic hypermutation status. Furthermore, we identified dominant clonotypes belonging to major stereotyped subsets associated with poor prognosis up to 16 years before diagnosis in 14 patients with CLL. In 22 patients with longitudinal samples, the skewing of the BcR IGH gene repertoire increased significantly over time to diagnosis or remained stable at high levels. For 14 of 16 patients with available samples at diagnosis, the CLL clonotype was already present in the prediagnostic samples. Overall, our data indicate that the preclinical phase of CLL could be longer than previously thought, even in adverse-prognostic cases.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hosnijeh, Fatemeh SaberiDivision of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • Späth, FlorentinUmeå University (författare)
  • Hengeveld, Paul J.Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands,Erasmus University Medical Center (författare)
  • Agathangelidis, AndreasInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece (författare)
  • Saleh, ManalDivision of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • Casabonne, DelphineCentro de Investigación Biomédica en Red: Epidemiología y Salud Pública, Madrid, Spain; Unit of Molecular and Genetic Epidemiology in Infections and Cancer, Cancer Epidemiology Research Programme, Bellvitge Institute for Biomedical Research (IDIBELL), Catalan Institute of Oncology, Hospitalet De Llobregat, Barcelona, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Benavente, YolandaCentro de Investigación Biomédica en Red: Epidemiología y Salud Pública, Madrid, Spain; Unit of Molecular and Genetic Epidemiology in Infections and Cancer, Cancer Epidemiology Research Programme, Bellvitge Institute for Biomedical Research (IDIBELL), Catalan Institute of Oncology, Hospitalet De Llobregat, Barcelona, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Jerkeman, MatsLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund,Skåne University Hospital(Swepub:lu)onk-mje (författare)
  • Agudo, AntonioUnit of Nutrition and Cancer, Epidemiology, Public Health, Cancer Prevention, and Palliative Care Program, Bellvitge Biomedical Research Institute, Bellvitge Institute for Biomedical Research (IDIBELL), Catalan Institute of Oncology, Hospitalet De Llobregat, Barcelona, Spain (författare)
  • Barricarte, AurelioNavarra Public Health Institute, Navarra Institute for Health Research, Pamplona, Spain; Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain,Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Besson, CarolineUniversité Paris-Saclay, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), French Institute of Health and Medical Research (INSERM), Équipe “Exposome et Hérédité”, Centre de Recherche en épidémiologie et Santé des populations (CESP), Villejuif, France; Service d'Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France (författare)
  • Sánchez, Maria-JoseCentro de Investigación Biomédica en Red: Epidemiología y Salud Pública, Madrid, Spain; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Chirlaque, María-DoloresBiomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia University, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Masala, GiovannaEpidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy,Institute for Cancer Research, Prevention and Clinical Network (ISPRO) (författare)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy (författare)
  • Grioni, SaraEpidemiology and Prevention Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milano, Italy (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (författare)
  • Nieters, AlexandraInstitute for Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany (författare)
  • Engelfriet, PeterNational Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM) (författare)
  • Hultdin, MagnusUmeå University,Umeå universitet,Patologi(Swepub:umu)magn0001 (författare)
  • McKay, James D.Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization (författare)
  • Vermeulen, Roel C.H.Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (författare)
  • Langerak, Anton W.Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands,Erasmus University Medical Center (författare)
  • Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, Netherlands; Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, NetherlandsErasmus University Medical Center (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Blood: American Society of Hematology139:10, s. 1557-15630006-49711528-0020

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