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Plasma concentratio...
Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
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- Porta, Miquel (author)
- Hospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Gasull, Magda (author)
- Hospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Pumarega, Jose (author)
- Hospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Kiviranta, Hannu (author)
- Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland
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- Rantakokko, Panu (author)
- Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland
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- Raaschou-Nielsen, Ole (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Bergdahl, Ingvar (author)
- Umeå universitet,Enheten för biobanksforskning,Avdelningen för hållbar hälsa
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- Sandanger, Torkjel Manning (author)
- Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, Norway
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- Agudo, Antoni (author)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
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- Rylander, Charlotta (author)
- Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, Norway
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- Nost, Therese Haugdahl (author)
- Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, Norway
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- Donat-Vargas, Carolina (author)
- Karolinska Institutet
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- Aune, Dagfinn (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Heath, Alicia K. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Cirera, Lluis (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB Arrixaca, Murcia, Spain; Department of Health and Social Sciences, University of Murcia, Murcia, Spain
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- Goni-Irigoyen, Fernando (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Health Department of Basque Government, Public Health Laboratory in Gipuzkoa, San Sebastian, Spain; Health Research Institute Biodonostia, San Sebastian, Spain
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- Alguacil, Juan (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; University of Huelva, Huelva, Spain
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- Gimenez-Robert, Alex (author)
- Hospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain
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- Tjonneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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- Overvad, Kim (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark
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- Mancini, Francesca Romana (author)
- CESP Faculte de Medecine (USVQ), Universite Paris-Sud, INSERM, Universite Paris-Saclay, Villejuif, France; Inserm UMR1018, Institut Gustave Roussy, Villejuif, France
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- Rebours, Vinciane (author)
- Pancreatology Department, Beaujon Hospital, AP-HP, Clichy, France; Inserm UMR1149, DHU Unit, Paris-Diderot University, Paris, France
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- Boutron-Ruault, Marie-Christine (author)
- CESP Faculte de Medecine (USVQ), Universite Paris-Sud, INSERM, Universite Paris-Saclay, Villejuif, France; Inserm UMR1018, Institut Gustave Roussy, Villejuif, France
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- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam, Nuthetal, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens, Greece
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- Palli, Domenico (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network ISPRO, Florence, Italy
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- Grioni, Sara (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milan, Italy
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- Tumino, Rosario (author)
- Cancer Registry and Histopathology Department, Civic - M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy
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- Naccarati, Alessio (author)
- Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM), Turin, Italy
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- Panico, Salvatore (author)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Vermeulen, Roel (author)
- Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands
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- Quiros, J. Ramon (author)
- Public Health Directorate, Asturias, Spain
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- Rodriguez-Barranco, Miguel (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Publica (EASP), Instituto de Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain
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- Colorado-Yohar, Sandra M. (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB Arrixaca, Murcia, Spain; National Faculty of Public Health, University of Antioquia, Medellin, Colombia
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- Chirlaque, Maria-Dolores (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB Arrixaca, Murcia, Spain; Department of Health and Social Sciences, University of Murcia, Murcia, Spain
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- Ardanaz, Eva (author)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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- Wareham, Nick (author)
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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- Key, Tim (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Johansson, Mattias (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Murphy, Neil (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Huybrechts, Inge (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Chajes, Veronique (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Gonzalez, Carlos Alberto (author)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
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- Bueno-De-Mesquita, Bas (author)
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Gunter, Marc (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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- Riboli, Elio (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Duell, Eric J. (author)
- Oncology Data Analytics Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
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- Katzke, Verena (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Vineis, Paolo (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM), Turin, Italy
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(creator_code:org_t)
- 2021-07-14
- 2022
- English.
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In: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 51:2, s. 479-490
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Abstract
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- Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- biomarkers
- environmental health
- methods
- Pancreatic cancer
- persistent organic pollutants
- Surgery
- kirurgi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Porta, Miquel
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Gasull, Magda
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Pumarega, Jose
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Kiviranta, Hannu
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Rantakokko, Panu
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Raaschou-Nielsen ...
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Bergdahl, Ingvar
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Sandanger, Torkj ...
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Agudo, Antoni
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Rylander, Charlo ...
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Nost, Therese Ha ...
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Donat-Vargas, Ca ...
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Aune, Dagfinn
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Heath, Alicia K.
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Cirera, Lluis
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Goni-Irigoyen, F ...
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Alguacil, Juan
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Gimenez-Robert, ...
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Tjonneland, Anne
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Sund, Malin
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Overvad, Kim
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Mancini, Frances ...
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Rebours, Vincian ...
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Boutron-Ruault, ...
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Kaaks, Rudolf
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Schulze, Matthia ...
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Trichopoulou, An ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Naccarati, Aless ...
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Panico, Salvator ...
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Vermeulen, Roel
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Quiros, J. Ramon
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Rodriguez-Barran ...
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Colorado-Yohar, ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Wareham, Nick
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Key, Tim
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Johansson, Matti ...
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Murphy, Neil
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Ferrari, Pietro
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Huybrechts, Inge
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Chajes, Veroniqu ...
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Gonzalez, Carlos ...
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Bueno-De-Mesquit ...
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Gunter, Marc
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Weiderpass, Elis ...
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Riboli, Elio
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Duell, Eric J.
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Katzke, Verena
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Vineis, Paolo
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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International Jo ...
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Umeå University
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Karolinska Institutet