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  • Porta, MiquelHospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)

Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-07-14
  • Oxford University Press,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-203107
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203107URI
  • https://doi.org/10.1093/ije/dyab115DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148794115URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gasull, MagdaHospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
  • Pumarega, JoseHospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
  • Kiviranta, HannuDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland (författare)
  • Rantakokko, PanuDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland (författare)
  • Raaschou-Nielsen, OleDanish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Bergdahl, IngvarUmeå universitet,Enheten för biobanksforskning,Avdelningen för hållbar hälsa(Swepub:umu)inbe0001 (författare)
  • Sandanger, Torkjel ManningDepartment of Community Medicine, UiT-The Arctic University of Norway, Tromso, Norway (författare)
  • Agudo, AntoniUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain (författare)
  • Rylander, CharlottaDepartment of Community Medicine, UiT-The Arctic University of Norway, Tromso, Norway (författare)
  • Nost, Therese HaugdahlDepartment of Community Medicine, UiT-The Arctic University of Norway, Tromso, Norway (författare)
  • Donat-Vargas, CarolinaKarolinska Institutet (författare)
  • Aune, DagfinnDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Cirera, LluisSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB Arrixaca, Murcia, Spain; Department of Health and Social Sciences, University of Murcia, Murcia, Spain (författare)
  • Goni-Irigoyen, FernandoSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Health Department of Basque Government, Public Health Laboratory in Gipuzkoa, San Sebastian, Spain; Health Research Institute Biodonostia, San Sebastian, Spain (författare)
  • Alguacil, JuanSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; University of Huelva, Huelva, Spain (författare)
  • Gimenez-Robert, AlexHospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain (författare)
  • Tjonneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Sund, MalinUmeå universitet,Kirurgi(Swepub:umu)masu0021 (författare)
  • Overvad, KimDepartment of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Mancini, Francesca RomanaCESP Faculte de Medecine (USVQ), Universite Paris-Sud, INSERM, Universite Paris-Saclay, Villejuif, France; Inserm UMR1018, Institut Gustave Roussy, Villejuif, France (författare)
  • Rebours, VincianePancreatology Department, Beaujon Hospital, AP-HP, Clichy, France; Inserm UMR1149, DHU Unit, Paris-Diderot University, Paris, France (författare)
  • Boutron-Ruault, Marie-ChristineCESP Faculte de Medecine (USVQ), Universite Paris-Sud, INSERM, Universite Paris-Saclay, Villejuif, France; Inserm UMR1018, Institut Gustave Roussy, Villejuif, France (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam, Nuthetal, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany (författare)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens, Greece (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network ISPRO, Florence, Italy (författare)
  • Grioni, SaraEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milan, Italy (författare)
  • Tumino, RosarioCancer Registry and Histopathology Department, Civic - M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy (författare)
  • Naccarati, AlessioMolecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM), Turin, Italy (författare)
  • Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (författare)
  • Vermeulen, RoelInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands (författare)
  • Quiros, J. RamonPublic Health Directorate, Asturias, Spain (författare)
  • Rodriguez-Barranco, MiguelSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Publica (EASP), Instituto de Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain (författare)
  • Colorado-Yohar, Sandra M.Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB Arrixaca, Murcia, Spain; National Faculty of Public Health, University of Antioquia, Medellin, Colombia (författare)
  • Chirlaque, Maria-DoloresSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB Arrixaca, Murcia, Spain; Department of Health and Social Sciences, University of Murcia, Murcia, Spain (författare)
  • Ardanaz, EvaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (författare)
  • Wareham, NickMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom (författare)
  • Key, TimCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Johansson, MattiasInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Murphy, NeilInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Ferrari, PietroInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Huybrechts, IngeInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Chajes, VeroniqueInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Gonzalez, Carlos AlbertoUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain (författare)
  • Bueno-De-Mesquita, BasDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands (författare)
  • Gunter, MarcInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer (IARC), World Health Organization, Lyon, France (författare)
  • Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Duell, Eric J.Oncology Data Analytics Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain (författare)
  • Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Vineis, PaoloDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM), Turin, Italy (författare)
  • Hospital Del Mar Institute of Medical Research (IMIM PSMar), Barcelona, Spain; Universitat Autonoma de Barcelona, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, SpainDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Epidemiology: Oxford University Press51:2, s. 479-4900300-57711464-3685

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