Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010

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Stattin, Eva-LenaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (författare)

Cohort profile : the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010

Artikel/kapitelEngelska2022

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2022-05-10
BMJ Publishing Group Ltd,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-203155
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203155URI
https://doi.org/10.1136/bmjopen-2021-055557DOI

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Språk:engelska
Sammanfattning på:engelska

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PURPOSE: The rationale behind the SUDden cardiac Death in the Young (SUDDY) cohort was to provide a complete nationwide, high-quality platform with integrated multisource data, for clinical and genetic research on sudden cardiac death (SCD) in the young, with the ultimate goal to predict and prevent SCD.PARTICIPANTS: The cohort contains all SCD victims <36 years, in Sweden during the period 2000-2010. We assigned five population-based controls per case, together with parents of cases and controls, in total 15 633 individuals. Data of all individuals were extracted from multiple mandatory registries; the National Patient Registry, the Medical Birth Registry, the Prescribed Drug registry, the Cause of Death registry, the Multigeneration Registry, combined with socioeconomic data from Statistics Sweden. From SCD victims, the autopsy report, medical records, ECGs, parental information and biological samples were gathered.FINDINGS TO DATE: We identified 903 individuals diagnosed with SCD (67% men, 33% women). The cases comprised 236 infants <1 year of age (26%), 90 individuals aged 1-15 years (10%), 186 individuals aged 15-25 years (21%) and 391 aged 25-35 years (43%). Hospitalisations and outpatient clinic visits due to syncope were significantly more common among cases than controls. DNA obtained from dried blood spots tests (DBS) stored from birth was equally suitable as venous blood samples for high-throughput genetic analysis of SCD cases.FUTURE PLANS: We will explore the SUDDY cohort for symptoms and healthcare consumption, socioeconomic variables and family history of SCD. Furthermore, we will perform whole exome sequencing analysis on DNA of cases obtained from DBS or postmortem samples together with parental blood samples in search for gene variants associated with cardiac disease. The genetic analysis together with data compiled in the nationwide cohort is expected to improve current knowledge on the incidence, aetiology, clinical characteristics and family history of SCD.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Cardiology
epidemiology
forensic medicine
Forensic pathology
genetics

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hagström, EmilUppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden (författare)
Dahl, NiklasDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden (författare)
Strömsöe, AnneliSchool of Education, Dalarna University, Health and Social Studies, Falun, Sweden; Centre for Clinical Research Dalarna, Uppsala University, Falun, Sweden (författare)
Delgado-Vega, Angelica MariaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (författare)
Klar, JoakimDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden (författare)
Svennblad, BodilDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden (författare)
Börjesson, MatsDepartment of Molecular and Clinial Medicine, Sahlgrenska Academy, Göteborg university, Göteborg, Sweden; Center for Health and Performance, Department of Food, Nutrition and Sport Science, Göteborg university, Göteborg, Sweden (författare)
Wisten, AaseUmeå universitet,Geriatrik(Swepub:umu)aawi0001 (författare)
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenUppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden (creator_code:org_t)

Sammanhörande titlar

Ingår i:BMJ Open: BMJ Publishing Group Ltd12:52044-6055

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Av författaren/redakt...: Stattin, Eva-Len ...; Hagström, Emil; Dahl, Niklas; Strömsöe, Anneli; Delgado-Vega, An ...; Klar, Joakim; visa fler...; Svennblad, Bodil; Börjesson, Mats; Wisten, Aase; visa färre...

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Av lärosätet: Umeå universitet

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