SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Shen Sipeng)
 

Sökning: WFRF:(Shen Sipeng) > A Large-Scale Genom...

  • Zhang, RuyangDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China (författare)

A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-203216
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203216URI
  • https://doi.org/10.1016/j.jtho.2022.04.011DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: Although genome-wide association studies have been conducted to investigate genetic variation of lung tumorigenesis, little is known about gene-gene (G × G) interactions that may influence the risk of non-small cell lung cancer (NSCLC).Methods: Leveraging a total of 445,221 European-descent participants from the International Lung Cancer Consortium OncoArray project, Transdisciplinary Research in Cancer of the Lung and UK Biobank, we performed a large-scale genome-wide G × G interaction study on European NSCLC risk by a series of analyses. First, we used BiForce to evaluate and rank more than 58 billion G × G interactions from 340,958 single-nucleotide polymorphisms (SNPs). Then, the top interactions were further tested by demographically adjusted logistic regression models. Finally, we used the selected interactions to build lung cancer screening models of NSCLC, separately, for never and ever smokers.Results: With the Bonferroni correction, we identified eight statistically significant pairs of SNPs, which predominantly appeared in the 6p21.32 and 5p15.33 regions (e.g., rs521828C6orf10 and rs204999PRRT1, ORinteraction = 1.17, p = 6.57 × 10−13; rs3135369BTNL2 and rs2858859HLA-DQA1, ORinteraction = 1.17, p = 2.43 × 10−13; rs2858859HLA-DQA1 and rs9275572HLA-DQA2, ORinteraction = 1.15, p = 2.84 × 10−13; rs2853668TERT and rs62329694CLPTM1L, ORinteraction = 0.73, p = 2.70 × 10−13). Notably, even with much genetic heterogeneity across ethnicities, three pairs of SNPs in the 6p21.32 region identified from the European-ancestry population remained significant among an Asian population from the Nanjing Medical University Global Screening Array project (rs521828C6orf10 and rs204999PRRT1, ORinteraction = 1.13, p = 0.008; rs3135369BTNL2 and rs2858859HLA-DQA1, ORinteraction = 1.11, p = 5.23 × 10−4; rs3135369BTNL2 and rs9271300HLA-DQA1, ORinteraction = 0.89, p = 0.006). The interaction-empowered polygenetic risk score that integrated classical polygenetic risk score and G × G information score was remarkable in lung cancer risk stratification.Conclusions: Important G × G interactions were identified and enriched in the 5p15.33 and 6p21.32 regions, which may enhance lung cancer screening models.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Shen, SipengDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Wei, YongyueDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China (författare)
  • Zhu, YingDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Li, YiDepartment of Biostatistics, University of Michigan, MI, Ann Arbor, United States (författare)
  • Chen, JiajinDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Guan, JinxingDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Pan, ZouchengDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Wang, YuzhuoDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Zhu, MengDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Xie, JunxingDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Xiao, XiangjunThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston (författare)
  • Zhu, DakaiThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston (författare)
  • Li, YafangThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston (författare)
  • Albanes, DemetriosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda (författare)
  • Landi, Maria TeresaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda (författare)
  • Caporaso, Neil E.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda (författare)
  • Lam, StephenDepartment of Medicine, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada (författare)
  • Tardon, AdoninaFaculty of Medicine, University of Oviedo and CIBERESP, Oviedo, Spain (författare)
  • Chen, ChuDepartment of Epidemiology, University of Washington School of Public Health, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Bojesen, Stig E.Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark (författare)
  • Johansson, MattiasSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Risch, AngelaDepartment of Biosciences and Cancer Cluster Salzburg, University of Salzburg, Salzburg, Austria (författare)
  • Bickeböller, HeikeDepartment of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany (författare)
  • Wichmann, H-ErichInstitute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany (författare)
  • Rennert, GadiClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Carmel, Israel (författare)
  • Arnold, SusanneMarkey Cancer Center, University of Kentucky, Kentucky, Lexington (författare)
  • Brennan, PaulSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • McKay, James D.Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Field, John K.Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom (författare)
  • Shete, Sanjay S.Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Texas, Houston (författare)
  • Le Marchand, LoicEpidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States (författare)
  • Liu, GeoffreyPrincess Margaret Cancer Centre, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (författare)
  • Andrew, Angeline S.Department of Epidemiology, Department of Community and Family Medicine, Dartmouth Geisel School of Medicine, New Hampshire, Hanover (författare)
  • Kiemeney, Lambertus A.Department for Health Evidence, Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands (författare)
  • Zienolddiny-Narui, ShanNational Institute of Occupational Health, Oslo, Norway (författare)
  • Behndig, Annelie F.,1963-Umeå universitet,Avdelningen för medicin(Swepub:umu)anbe0145 (författare)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
  • Cox, AngelaDepartment of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, United Kingdom (författare)
  • Lazarus, PhilipDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States (författare)
  • Schabath, Matthew B.Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Florida, Tampa (författare)
  • Aldrich, Melinda C.Department of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Dai, JunchengDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Ma, HongxiaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Zhao, YangDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Hu, ZhibinChina International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Hung, Rayjean J.Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada (författare)
  • Amos, Christopher I.The Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston (författare)
  • Shen, HongbingChina International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Chen, FengDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China (författare)
  • Christiani, David C.Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Massachusetts, Boston (författare)
  • Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, ChinaDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Thoracic Oncology: Elsevier17:8, s. 974-9901556-08641556-1380

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy