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Early-life risk fac...
Early-life risk factors for development of asthma from 8 to 28 years of age : a prospective cohort study
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Almqvist, Linnea (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Bjerg, Anders (författare)
- Martina Children’s Hospital, Stockholm, Sweden
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- Andersson, Martin (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Backman, Helena (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Perzanowski, Matthew S. (författare)
- Dept of Environmental Health Sciences, Mailman School of Public Health, Columbia University, NY, New York, United States
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- 2022-06-30
- 2022
- Engelska.
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Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 8:4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages.Methods: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invited) was recruited at age 8 years to a prospective study about asthma. The cohort was followed annually from age 8 to 19 years and at 28 years by questionnaire surveys (67% of the original cohort participated). Asthma was categorised as never-asthma, onset age ⩽8 years, onset age 9–13 years, onset age 14–19 years or onset age >19 years.Results: Of the 3430 individuals in the cohort, 690 (20.1%) reported asthma in any survey. The average incidence rate was 10.0/1000 per year at ⩽8 years, 11.9/1000 per year at 9–13 years, 13.3/1000 per year at 14–19 years and 6.1/1000 per year at >19 years. The incidence was higher among boys until age 10 years, but from age 15 years, it became higher among girls. Family history of asthma, allergic sensitisation and breastfeeding <3 months were associated with asthma onset throughout the study. Low birthweight, maternal smoking during pregnancy, severe respiratory infection, rhinoconjunctivitis and eczema were associated with asthma onset ⩽8 and 9–13 years.Conclusions: The incidence of asthma was high during childhood and the teenage period, and decreased substantially during young adulthood. Early-life factors were associated with asthma onset throughout childhood but had also a lasting effect on asthma incidence until adulthood.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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