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Long-term time tren...
Long-term time trends in reactivated herpes simplex infections and treatment in Sweden
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- Lopatko Lindman, Karin (author)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden.
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- Lockman-Lundgren, Judith (author)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden.
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- Weidung, Bodil (author)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden
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- Olsson, Jan (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Lövheim, Hugo, 1981- (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med WCMM, Umeå, Sweden.
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(creator_code:org_t)
- 2022-06-15
- 2022
- English.
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In: BMC Infectious Diseases. - : BioMed Central (BMC). - 1471-2334. ; 22:1
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Abstract
Subject headings
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- Background: Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population.Methods: The study comprised 2879 anti-HSV-1 immunoglobulin (Ig) G positive subjects from five different cohorts who had donated serum from 1988 to 2010. The sera were analyzed for anti-HSV IgM using enzyme-linked immunosorbent assay. Associations between the presence of anti-HSV IgM antibodies, the apolipoprotein E ε4 allele and the serum sampling year were assessed by logistic regression. Seasonality of anti-HSV IgM was evaluated in a UV radiation model. Data of antiviral drugs for the entire Swedish population were compiled from two different nationwide databases: the Swedish Prescribed Drug Register and the Swedish Association of the Pharmaceutical Industry.Results: Cross-sectional and longitudinal analyses indicated that the prevalence of anti-HSV IgM antibodies declined between 1988 and 2010 (odds ratio [OR] = 0.912, p <.001), while the total annual use of antiviral drugs in Sweden gradually increased from 1984 to 2017. Higher UV radiation was associated with higher prevalence of anti-HSV IgM antibodies (OR = 1.071, p =.043).Conclusion: The declining time trend of HSV reactivation in a Swedish cohort coincides with a steady increase of antiviral drug use in the Swedish general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Antiviral agents
- Apolipoprotein E4
- Cohort study
- Epidemiology
- Herpes simplex
- Seroprevalence
- Ultraviolet radiation
Publication and Content Type
- ref (subject category)
- art (subject category)
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