Digital delivery of behavioural activation therapy to overcome depression and facilitate social and economic transitions of adolescents in South Africa (the DoBAt study): protocol for a pilot randomised controlled trial

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Digital delivery of behavioural activation therapy to overcome depression and facilitate social and economic transitions of adolescents in South Africa (the DoBAt study) : protocol for a pilot randomised controlled trial

Moffett, Bianca D. (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Pozuelo, Julia R. (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Psychiatry, University of Oxford, Oxford, United Kingdom

van Heerden, Alastair (författare): Center for Community Based Research, Human Sciences Research Council, Pietermaritzburg, South Africa; MRC/Wits Developmental Pathways for Health Research Unit, University of the Witwatersrand, Johannesburg, South Africa

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O'Mahen, Heather A. (författare): Mood Disorders Centre, Department of Psychology, University of Exeter, Exeter, Devon, UK

Craske, Michelle (författare): Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (UCLA), CA, Los Angeles, United States; Department of Psychology, University of California Los Angeles (UCLA), CA, Los Angeles, United States

Sodi, Tholene (författare): Psychology, University of Limpopo, Limpopo, South Africa

Lund, Crick (författare): Alan J Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa; Centre for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Orkin, Kate (författare): Blavatnik School of Government, University of Oxford, Oxford, United Kingdom

Kilford, Emma J. (författare): Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom

Blakemore, Sarah-Jayne (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Mahmud, Mahreen (författare): Department of Economics, University of Exeter, Exeter, United Kingdom

Musenge, Eustasius (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Division of Epidemiology and Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Davis, Meghan (författare): Department of Psychiatry, University of Oxford, Oxford, United Kingdom

Makhanya, Zamakhanya (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Baloyi, Tlangelani (författare): Department of Psychology, University of Limpopo, Polokwane, South Africa

Mahlangu, Daniel (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Chierchia, Gabriele (författare): Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Fielmann, Sophie L. (författare): Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Gómez-Olivé, F Xavier (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Valodia, Imraan (författare): Southern Centre for Inequality Studies, University of the Witwatersrand, Johannesburg, South Africa

Tollman, Stephen M. (författare): Umeå universitet,Institutionen för epidemiologi och global hälsa,Institutionen för folkhälsa och klinisk medicin,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Kahn, Kathleen (författare): Umeå universitet,Institutionen för epidemiologi och global hälsa,Institutionen för folkhälsa och klinisk medicin,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Stein, Alan (författare): MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Psychiatry, University of Oxford, Oxford, United Kingdom

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2022-12-30
2022
Engelska.
Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 12:12

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INTRODUCTION: Scalable psychological treatments to address depression among adolescents are urgently needed. This is particularly relevant to low-income and middle-income countries where 90% of the world's adolescents live. While digital delivery of behavioural activation (BA) presents a promising solution, its feasibility, acceptability and effectiveness among adolescents in an African context remain to be shown.METHODS AND ANALYSIS: This study is a two-arm single-blind individual-level randomised controlled pilot trial to assess the feasibility, acceptability and initial efficacy of digitally delivered BA therapy among adolescents with depression. The intervention has been coproduced with adolescents at the study site. The study is based in the rural northeast of South Africa in the Bushbuckridge subdistrict of Mpumalanga province. A total of 200 adolescents with symptoms of mild to moderately severe depression on the Patient Health Questionnaire Adolescent Version will be recruited (1:1 allocation ratio). The treatment group will receive BA therapy via a smartphone application (the Kuamsha app) supported by trained peer mentors. The control group will receive an enhanced standard of care. The feasibility and acceptability of the intervention will be evaluated using a mixed methods design, and signals of the initial efficacy of the intervention in reducing symptoms of depression will be determined on an intention-to-treat basis. Secondary objectives are to pilot a range of cognitive, mental health, risky behaviour and socioeconomic measures; and to collect descriptive data on the feasibility of trial procedures to inform the development of a further larger trial.ETHICS AND DISSEMINATION: This study has been approved by the University of the Witwatersrand Human Research Ethics Committee (MED20-05-011) and the Oxford Tropical Research Ethics Committee (OxTREC 34-20). Study findings will be published in scientific open access peer-reviewed journals, presented at scientific conferences and communicated to participants, their caregivers, public sector officials and other relevant stakeholders.TRIAL REGISTRATION NUMBERS: This trial was registered on 19 November 2020 with the South African National Clinical Trials Registry (DOH-27-112020-5741) and the Pan African Clinical Trials Registry (PACTR202206574814636).

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Digital delivery of behavioural activation therapy to overcome depression and facilitate social and economic transitions of adolescents in South Africa (the DoBAt study) : protocol for a pilot randomised controlled trial

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