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Protocols, methods, and tools for genome-wide association studies (GWAS) of dental traits

Agler, Cary S. (författare)
Oral and Craniofacial Health Sciences, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Shungin, Dmitry (författare)
Umeå universitet,Institutionen för odontologi,Broad Institute of the Massachusetts Institute of Technology and Harvard University, MA, Cambridge, United States
Ferreira Zandoná, Andrea G. (författare)
Department of Comprehensive Dentistry, Tufts University School of Dental Medicine, Tufts University, MA, Boston, United States
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Schmadeke, Paige (författare)
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Biospecimen Core Processing Facility, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Basta, Patricia V. (författare)
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Biospecimen Core Processing Facility, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Luo, Jason (författare)
Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, NC, Chapel Hill, United States; Mammalian Genotyping Core, University of North Carolina, NC, Chapel Hill, United States
Cantrell, John (författare)
Oral and Craniofacial Health Sciences, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Pahel, Thomas D. (författare)
Oral and Craniofacial Health Sciences, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Meyer, Beau D. (författare)
Department of Pediatric Dentistry, UNC School of Dentistry, CB#7450, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Shaffer, John R. (författare)
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, PA, Pittsburgh, United States; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, PA, Pittsburgh, United States; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
Schaefer, Arne S. (författare)
Department of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité—University Medicine Berlin, Berlin, Germany
North, Kari E. (författare)
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Carolina Center for Genome Sciences, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
Divaris, Kimon (författare)
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Department of Pediatric Dentistry, UNC School of Dentistry, CB#7450, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States
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 (creator_code:org_t)
2019-03-06
2019
Engelska.
Ingår i: Odontogenesis. - New York, NY : Humana Press. - 9781493990115 - 9781493990122 ; , s. 493-509
Relaterad länk:
https://europepmc.or...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Bokkapitel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Oral health and disease are known to be influenced by complex interactions between environmental (e.g., social and behavioral) factors and innate susceptibility. Although the exact contribution of genomics and other layers of "omics" to oral health is an area of active research, it is well established that the susceptibility to dental caries, periodontal disease, and other oral and craniofacial traits is substantially influenced by the human genome. A comprehensive understanding of these genomic factors is necessary for the realization of precision medicine in the oral health domain. To aid in this direction, the advent and increasing affordability of high-throughput genotyping has enabled the simultaneous interrogation of millions of genetic polymorphisms for association with oral and craniofacial traits. Specifically, genome-wide association studies (GWAS) of dental caries and periodontal disease have provided initial insights into novel loci and biological processes plausibly implicated in these two common, complex, biofilm-mediated diseases. This paper presents a summary of protocols, methods, tools, and pipelines for the conduct of GWAS of dental caries, periodontal disease, and related traits. The protocol begins with the consideration of different traits for both diseases and outlines procedures for genotyping, quality control, adjustment for population stratification, heritability and association analyses, annotation, reporting, and interpretation. Methods and tools available for GWAS are being constantly updated and improved; with this in mind, the presented approaches have been successfully applied in numerous GWAS and meta-analyses among tens of thousands of individuals, including dental traits such as dental caries and periodontal disease. As such, they can serve as a guide or template for future genomic investigations of these and other traits.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

Bioinformatics
Dental caries
Genome-wide association studies
Methods
Periodontal disease
Periodontitis
Protocol

Publikations- och innehållstyp

ref (ämneskategori)
kap (ämneskategori)

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