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  • Divaris, KimonDepartment of Pediatric Dentistry, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)

The supragingival biofilm in early childhood caries : clinical and laboratory protocols and bioinformatics pipelines supporting metagenomics, metatranscriptomics, and metabolomics studies of the oral microbiome

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-03-06
  • New York, NY :Humana Press,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-203377
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203377URI
  • https://doi.org/10.1007/978-1-4939-9012-2_40DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:kap swepub-publicationtype

Anmärkningar

  • Early childhood caries (ECC) is a biofilm-mediated disease. Social, environmental, and behavioral determinants as well as innate susceptibility are major influences on its incidence; however, from a pathogenetic standpoint, the disease is defined and driven by oral dysbiosis. In other words, the disease occurs when the natural equilibrium between the host and its oral microbiome shifts toward states that promote demineralization at the biofilm-tooth surface interface. Thus, a comprehensive understanding of dental caries as a disease requires the characterization of both the composition and the function or metabolic activity of the supragingival biofilm according to well-defined clinical statuses. However, taxonomic and functional information of the supragingival biofilm is rarely available in clinical cohorts, and its collection presents unique challenges among very young children. This paper presents a protocol and pipelines available for the conduct of supragingival biofilm microbiome studies among children in the primary dentition, that has been designed in the context of a large-scale population-based genetic epidemiologic study of ECC. The protocol is being developed for the collection of two supragingival biofilm samples from the maxillary primary dentition, enabling downstream taxonomic (e.g., metagenomics) and functional (e.g., transcriptomics and metabolomics) analyses. The protocol is being implemented in the assembly of a pediatric precision medicine cohort comprising over 6000 participants to date, contributing social, environmental, behavioral, clinical, and biological data informing ECC and other oral health outcomes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Shungin, DmitryUmeå universitet,Institutionen för odontologi,Broad Institute of the Massachusetts Institute of Technology and Harvard University, MA, Cambridge, United States(Swepub:umu)dmsh0003 (författare)
  • Rodríguez-Cortés, AdarisDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Biospecimen Core Processing Facility, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Basta, Patricia V.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Biospecimen Core Processing Facility, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Roach, JeffResearch Computing, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Cho, HunyongDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Wu, DiDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Department of Periodontology, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Ferreira Zandoná, Andrea G.Department of Comprehensive Dentistry, Tufts University School of Dental Medicine, Tufts University, MA, Boston, United States (författare)
  • Ginnis, JeannieDepartment of Pediatric Dentistry, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Ramamoorthy, SivapriyaMetabolon, Inc., NC, Durham, United States (författare)
  • Kinchen, Jason M.Metabolon, Inc., NC, Durham, United States (författare)
  • Kwintkiewicz, JakubDivision of Gastroenterology and Hepatology, Department of Medicine, Microbiome Core Facility, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, NC, Chapel Hill, United States (författare)
  • Butz, NatashaMicrobiome Core Facility, Department of Cell Biology and Physiology, School of Medicine, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Division of Gastroenterology and Hepatology, School of Medicine, Department of Medicine, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Ribeiro, Apoena A.Department of Diagnostic Sciences, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States (författare)
  • Azcarate-Peril, M. AndreaCenter for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina, NC, Chapel Hill, United States (författare)
  • Department of Pediatric Dentistry, UNC School of Dentistry, University of North Carolina-Chapel Hill, NC, Chapel Hill, United States; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, Chapel Hill, United StatesInstitutionen för odontologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:OdontogenesisNew York, NY : Humana Press, s. 525-54897814939901159781493990122

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