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  • Dam, VeerleJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, Netherlands (författare)

Association of menopausal characteristics and risk of coronary heart disease : A pan-European case-cohort analysis

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-02-22
  • Oxford University Press,2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-203494
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203494URI
  • https://doi.org/10.1093/ije/dyz016DOI
  • https://lup.lub.lu.se/record/f97f0591-41a9-44fa-b283-18c63c701987URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141793701URI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these associations are explained by established cardiovascular risk factors.Methods: We used data from EPIC-CVD, a case-cohort study, which includes data from 23 centres from 10 European countries. We included only women, of whom 10 880 comprise the randomly selected sub-cohort, supplemented with 4522 cases outside the sub-cohort. We conducted Prentice-weighted Cox proportional hazards regressions with age as the underlying time scale, stratified by country and adjusted for relevant confounders.Results: After confounder and intermediate adjustment, post-menopausal women were not at higher CHD risk compared with pre-menopausal women. Among post-menopausal women, earlier menopause was linearly associated with higher CHD risk [HRconfounder and intermediate adjusted per-year decrease = 1.02, 95% confidence interval (CI) = 1.01-1.03, p = 0.001]. Women with a surgical menopause were at higher risk of CHD compared with those with natural menopause (HRconfounder-adjusted = 1.25, 95% CI = 1.10-1.42, p < 0.001), but this attenuated after additional adjustment for age at menopause and intermediates (HR = 1.12, 95% CI = 0.96-1.29, p = 0.15). A proportion of the association was explained by cardiovascular risk factors.Conclusions: Earlier and surgical menopause were associated with higher CHD risk. These associations could partially be explained by differences in conventional cardiovascular risk factors. These women might benefit from close monitoring of cardiovascular risk factors and disease.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Van Der Schouw, Yvonne T.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands (författare)
  • Onland-Moret, N. CharlotteJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands (författare)
  • Groenwold, Rolf H. H.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands (författare)
  • Peters, Sanne A. E.George Institute for Global Health, University of Oxford, Oxford, United Kingdom (författare)
  • Burgess, StephenMRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (författare)
  • Wood, Angela M.Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (författare)
  • Chirlaque, Maria-DoloresDepartment of Epidemiology, Regional Health Authority, IMIB-Arraxaca, Murcia University, Murcia, Spain; Department of Epidemiology, CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Moons, Karel G. M.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands,International Agency for Research on Cancer, World Health Organization,Cancer Research and Prevention Institute (ISPO),University of Turin (författare)
  • Oliver-Williams, ClareCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom (författare)
  • Schuit, EwoudJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands (författare)
  • Tikk, KajaDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research (författare)
  • Holm, MarianneDepartment of Diet Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Tjønneland, AnneDepartment of Diet Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Kühn, TilmanDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Fortner, Renée T.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Trichopoulou, Antonia2nd Pulmonary Medicine Department, Hellenic Health Foundation, Athens, Greece; Department of Hygiene Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian, University of Athens, Athens, Greece (författare)
  • Karakatsani, Anna2nd Pulmonary Medicine Department, Hellenic Health Foundation, Athens, Greece; 2nd Pulmonary Medicine Department, School of Medicine, National, Kapodistrian University of Athens, ATTIKON' University Hospital, Haidari, Greece (författare)
  • La Vecchia, Carlo2nd Pulmonary Medicine Department, Hellenic Health Foundation, Athens, Greece; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy (författare)
  • Ferrari, PietroInternational Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization (författare)
  • Gunter, MarcInternational Agency for Research on Cancer, Lyon, France (författare)
  • Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy (författare)
  • Sieri, SabinaEpidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale Dei Tumori, Milan, Italy (författare)
  • Tumino, RosarioCancer Registry and Histopathology Department, 'Civic-M.P.Arezzo' Hospital, ASP Ragusa, Ragusa, Italy (författare)
  • Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (författare)
  • Boer, Jolanda M. A.Center for Nutrition Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands (författare)
  • Monique Verschuren, W.M.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands; Center for Nutrition Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands (författare)
  • Salamanca-Fernández, ElenaDepartment of Epidemiology, CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria Ibs, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Arriola, LarraitzDepartment of Epidemiology, CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Instituto BIO-Donostia, Basque Government, Donostia, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Moreno-Iribas, ConchiInstituto de Salud Pública de Navarra, IdiSNA, Navarre Institute for Health Research, Pamplona, Spain; Red de Servicios de Salud Orientados A Enfermedades Crónicas, REDISSEC, Pamplona, Spain (författare)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
  • Nordendahl, MariaUmeå University,Umeå universitet,Allmänmedicin(Swepub:umu)maacln97 (författare)
  • Wennberg, Patrik,1972-Umeå University,Umeå universitet,Allmänmedicin(Swepub:umu)pawe0002 (författare)
  • Key, Timothy J.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Colorado-Yohar, SandraDepartment of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (författare)
  • Matullo, GiuseppeDepartment of Medical Sciences, University of Torino, Turin, Italy; Department Medical Sciences, Italian Institute for Genomic Medicine -IIGM/HuGeF, Turin, Italy (författare)
  • Overvad, KimDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark (författare)
  • Clavel-Chapelon, FrancoiseINSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones, and Women's Health Team, Institut Gustave Roussy, Villejuif, France (författare)
  • Boeing, HeinerDepartment of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany (författare)
  • Ramon Quiros, J.Public Health Direct., Asturias, Spain,Public Health Directorate (författare)
  • Di Angelantonio, EmanueleMRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Langenberg, ClaudiaMRC Epidemiology Unit, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Sweeting, Michael J.MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom (författare)
  • Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Wareham, Nicholas J.MRC Epidemiology Unit, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Danesh, JohnMRC Epidemiology Unit, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Butterworth, AdamDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom (författare)
  • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, NetherlandsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnr. STR 6.131, GA Utrecht, Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Epidemiology: Oxford University Press48:4, s. 1275-12850300-57711464-3685

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