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Differential grey m...
Differential grey matter structure in women with premenstrual dysphoric disorder : evidence from brain morphometry and data-driven classification
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- Dubol, Manon (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuropsykofarmakologi
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- Stiernman, Louise (author)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, S-90185 Umeå, Sweden.
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- Wikström, Johan, 1964- (author)
- Uppsala universitet,Radiologi
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- Lanzenberger, Rupert (author)
- Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria,Med Univ Vienna, Dept Psychiat & Psychotherapy, A-1090 Vienna, Austria.
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- Neill Epperson, C. (author)
- Department of Psychiatry, Department of Family Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, CO, Aurora, United States,Univ Colorado, Dept Psychiat, Dept Family Med, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA.
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- Sundström Poromaa, Inger, 1964- (author)
- Uppsala universitet,Reproduktiv hälsa
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- Bixo, Marie (author)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, S-90185 Umeå, Sweden.
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- Comasco, Erika, 1982- (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Reproduktiv hälsa,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2022-06-15
- 2022
- English.
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In: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 12:1
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Abstract
Subject headings
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- Premenstrual dysphoric disorder (PMDD) is a female-specific condition classified in the Diagnostic and Statical Manual—5th edition under depressive disorders. Alterations in grey matter volume, cortical thickness and folding metrics have been associated with a number of mood disorders, though little is known regarding brain morphological alterations in PMDD. Here, women with PMDD and healthy controls underwent magnetic resonance imaging (MRI) during the luteal phase of the menstrual cycle. Differences in grey matter structure between the groups were investigated by use of voxel- and surface-based morphometry. Machine learning and multivariate pattern analysis were performed to test whether MRI data could distinguish women with PMDD from healthy controls. Compared to controls, women with PMDD had smaller grey matter volume in ventral posterior cortices and the cerebellum (Cohen’s d = 0.45–0.76). Region-of-interest analyses further indicated smaller volume in the right amygdala and putamen of women with PMDD (Cohen’s d = 0.34–0.55). Likewise, thinner cortex was observed in women with PMDD compared to controls, particularly in the left hemisphere (Cohen’s d = 0.20–0.74). Classification analyses showed that women with PMDD can be distinguished from controls based on grey matter morphology, with an accuracy up to 74%. In line with the hypothesis of an impaired top-down inhibitory circuit involving limbic structures in PMDD, the present findings point to PMDD-specific grey matter anatomy in regions of corticolimbic networks. Furthermore, the results include widespread cortical and cerebellar regions, suggesting the involvement of distinct networks in PMDD pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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