Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: (WFRF:(Turzanski Fortner Renee)) > Impact of cumulativ...

Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer : a multi-centre cohort study

Kohls, Mirjam (författare): Institute for Medical Information Processing, Biometry and Epidemiology – IBE, LMU Munich, Munich, Germany; Pettenkofer School of Public Health, Munich, Germany; Cancer Surveillance Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Freisling, Heinz (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Charvat, Hadrien (författare): Cancer Surveillance Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

visa fler...

Soerjomataram, Isabelle (författare): Cancer Surveillance Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Viallon, Vivian (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Davila-Batista, Veronica (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Kaaks, Rudolf (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Turzanski-Fortner, Renée (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Aleksandrova, Krasimira (författare): Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany

Schulze, Matthias B. (författare): Institute of Nutritional Science, University of Potsdam, Potsdam, Germany; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

Dahm, Christina C. (författare): Department of Public Health, Aarhus University, Aarhus, Denmark

Tilma Vistisen, Helene (författare): Department of Public Health, Aarhus University, Aarhus, Denmark

Rostgaard-Hansen, Agnetha Linn (författare): Danish Cancer Society Research Centre, Diet, Genes and Environment, Copenhagen, Denmark

Tjønneland, Anne (författare): Danish Cancer Society Research Centre, Diet, Genes and Environment, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark

Bonet, Catalina (författare): Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Institut Català d’Oncologia, Barcelona, Spain

Sánchez, Maria-Jose (författare): Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Universidad de Granada, Granada, Spain

Colorado-Yohar, Sandra (författare): Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; CIBER Epidemiología Y Salud Pública (CIBERESP), Madrid, Spain; Research Group On Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia

Masala, Giovanna (författare): Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy

Palli, Domenico (författare): Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy

Krogh, Vittorio (författare): Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di Milano, Milan, Italy

Ricceri, Fulvio (författare): Department of Clinical and Biological Sciences, University of Turin, Turin, Italy

Rolandsson, Olov (författare): Umeå universitet,Allmänmedicin

Lu, Sai San Moon (författare): Umeå universitet,Allmänmedicin

Tsilidis, Konstantinos K. (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

Weiderpass, Elisabete (författare): International Agency for Research on Cancer – IARC/WHO, Lyon, France

Gunter, Marc J. (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Ferrari, Pietro (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

Berger, Ursula (författare): Institute for Medical Information Processing, Biometry and Epidemiology – IBE, LMU Munich, Munich, Germany; Pettenkofer School of Public Health, Munich, Germany

Arnold, Melina (författare): Cancer Surveillance Branch, International Agency for Research on Cancer – IARC/WHO, 150 cours Albert Thomas, Lyon, France

visa färre...

(creator_code:org_t)

2022-05-14
2022
Engelska.
Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407. ; 22:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the mechanisms underlying these associations remain largely unexplored. We analysed these associations in colorectal and breast cancer patients.Methods: Based on repeated BMI assessments of cancer-free participants from four European countries in the European Prospective Investigation into Cancer and nutrition (EPIC) study, individual BMI-trajectories reflecting predicted mean BMI between ages 20 to 50 years were estimated using a growth curve model. Participants with incident colorectal or breast cancer after the age of 50 years were included in the survival analysis to study the prognostic effect of mean BMI and cardiometabolic diseases (CMD) prior to cancer. CMD were defined as one or more chronic conditions among stroke, myocardial infarction, and type 2 diabetes. Hazard ratios (HRs) and confidence intervals (CIs) of mean BMI and CMD were derived using multivariable-adjusted Cox proportional hazard regression for mean BMI and CMD separately and both exposures combined, in subgroups of localised and advanced disease.Results: In the total cohort of 159,045 participants, there were 1,045 and 1,620 eligible patients of colorectal and breast cancer. In colorectal cancer patients, a higher BMI (by 1 kg/m2) was associated with a 6% increase in risk of death (95% CI of HR: 1.02–1.10). The HR for CMD was 1.25 (95% CI: 0.97–1.61). The associations for both exposures were stronger in patients with localised colorectal cancer. In breast cancer patients, a higher BMI was associated with a 4% increase in risk of death (95% CI: 1.00–1.08). CMDs were associated with a 46% increase in risk of death (95% CI: 1.01–2.09). The estimates and CIs for BMI remained similar after adjustment for CMD and vice versa.Conclusions: Our results suggest that cumulative exposure to higher BMI during early to mid-adulthood was associated with poorer survival in patients with breast and colorectal cancer, independent of CMD prior to cancer diagnosis. The association between a CMD diagnosis prior to cancer and survival in patients with breast and colorectal cancer was independent of BMI.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Body mass index
Breast cancer
Cardiovascular disease
Cohort study
Colorectal cancer
Comorbidity
Cumulative exposure
Diabetes
Survival

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

BMC Cancer (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Artiklar i publikationen: BMC Cancer

Av lärosätet: Umeå universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se