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Association of iron deficiency with incident cardiovascular diseases and mortality in the general population

Schrage, Benedikt (författare)
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany
Rübsamen, Nicole (författare)
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany
Ojeda, Francisco M. (författare)
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany
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Thorand, Barbara (författare)
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany
Peters, Annette (författare)
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich, Munich, Germany
Koenig, Wolfgang (författare)
DZHK (German Center for Cardiovascular Research), partner site Munich, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
Söderberg, Stefan (författare)
Umeå universitet,Avdelningen för medicin
Söderberg, Maja (författare)
Umeå universitet,Avdelningen för medicin
Mathiesen, Ellisiv B. (författare)
Department of Community Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway
Njølstad, Inger (författare)
Department of Community Medicine, University of Tromsø The Arctic University of Norway, Tromsø, Norway
Kee, Frank (författare)
Centre for Public Health, Queens University of Belfast, Belfast, United Kingdom
Linneberg, Allan (författare)
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
Kuulasmaa, Kari (författare)
National Institute for Health and Welfare, Helsinki, Finland
Tarja, Palosaari (författare)
National Institute for Health and Welfare, Helsinki, Finland
Salomaa, Veikko (författare)
National Institute for Health and Welfare, Helsinki, Finland
Blankenberg, Stefan (författare)
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany
Zeller, Tanja (författare)
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany
Karakas, Mahir (författare)
Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany
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 (creator_code:org_t)
2021-10-05
2021
Engelska.
Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 8:6, s. 4584-4592
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://onlinelibrar...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims: Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population.Methods and results: In 12 164 individuals from three European population-based cohorts, AID was defined as ferritin < 100 μg/L or as ferritin < 30 μg/L (severe AID), and FID was defined as ferritin < 100 μg/L or ferritin 100–299 μg/L and transferrin saturation < 20%. The association between iron deficiency and incident coronary heart disease (CHD), CV mortality, and all-cause mortality was evaluated by Cox regression models. Population attributable fraction (PAF) was estimated. Median age was 59 (45–68) years; 45.2% were male. AID, severe AID, and FID were prevalent in 60.0%, 16.4%, and 64.3% of individuals. AID was associated with CHD [hazard ratio (HR) 1.20, 95% confidence interval (CI) 1.04–1.39, P = 0.01], but not with mortality. Severe AID was associated with all-cause mortality (HR 1.28, 95% CI 1.12–1.46, P < 0.01), but not with CV mortality/CHD. FID was associated with CHD (HR 1.24, 95% CI 1.07–1.43, P < 0.01), CV mortality (HR 1.26, 95% CI 1.03–1.54, P = 0.03), and all-cause mortality (HR 1.12, 95% CI 1.01–1.24, P = 0.03). Overall, 5.4% of all deaths, 11.7% of all CV deaths, and 10.7% of CHD were attributable to FID.Conclusions: In the general population, FID was highly prevalent, was associated with incident CHD, CV death, and all-cause death, and had the highest PAF for these events, whereas AID was only associated with CHD and severe AID only with all-cause mortality. This indicates that FID is a relevant risk factor for CV diseases in the general population.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Cardiovascular
General population
Iron deficiency
Mortality
Risk factor

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