Sökning: WFRF:(Vishram Nielsen Julie K.) >
Risk prediction of ...
Risk prediction of atrial fibrillation and its complications in the community using hs troponin I
-
- Börschel, Christin S. (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
-
- Geelhoed, Bastiaan (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
-
- Niiranen, Teemu (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland; Deparment of Internal Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland
-
visa fler...
-
- Camen, Stephan (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
-
- Donati, Maria Benedetta (författare)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
-
- Havulinna, Aki S. (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
-
- Gianfagna, Francesco (författare)
- Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy
-
- Palosaari, Tarja (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland
-
- Jousilahti, Pekka (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland
-
- Kontto, Jukka (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland
-
- Vartiainen, Erkki (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland
-
- Ojeda, Francisco M. (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany
-
- den Ruijter, Hester M. (författare)
- Laboratory for Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
-
- Costanzo, Simona (författare)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
-
- de Gaetano, Giovanni (författare)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
-
- Di Castelnuovo, Augusto (författare)
- Mediterranea Cardiocentro, Naples, Italy
-
- Linneberg, Allan (författare)
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
-
- Vishram-Nielsen, Julie K. (författare)
- Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
-
- Løchen, Maja-Lisa (författare)
- Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
-
- Koenig, Wolfgang (författare)
- German Heart Centre Munich, Technical University of Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
-
- Jørgensen, Torben (författare)
- Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
-
- Kuulasmaa, Kari (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland
-
- Blankenberg, Stefan (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
-
- Iacoviello, Licia (författare)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
-
- Zeller, Tanja (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany
-
- Söderberg, Stefan (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
- Salomaa, Veikko (författare)
- Finnish Institute for Health and Welfare, Helsinki, Finland
-
- Schnabel, Renate B. (författare)
- Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
-
visa färre...
-
(creator_code:org_t)
- 2023-01-17
- 2023
- Engelska.
-
Ingår i: European Journal of Clinical Investigation. - : John Wiley & Sons. - 0014-2972 .- 1365-2362. ; 53:5
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims: Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.Methods: We investigated the predictive ability of hsTnI for incident AF in 45,298 participants (median age 51.4 years, 45.0% men) across European community cohorts in comparison to CVRF and established biomarkers (C-reactive protein, N-terminal pro B-type natriuretic peptide).Results: During a median follow-up of 7.7 years, 1734 (3.8%) participants developed AF. Those in the highest hsTnI quarter (≥4.2 ng/L) had a 3.91-fold (95% confidence interval (CI) 3.30, 4.63; p <.01) risk for developing AF compared to the lowest quarter (<1.4 ng/L). In multivariable-adjusted Cox proportional hazards models a statistically significant association was seen between hsTnI and AF (hazard ratio (HR) per 1 standard deviation (SD) increase in log10(hsTnI) 1.08; 95% CI 1.01, 1.16; p =.03). Inclusion of hsTnI did improve model discrimination (C-index CVRF 0.811 vs. C-index CVRF and hsTnI 0.813; p <.01). Higher hsTnI concentrations were associated with heart failure (HR per SD 1.37; 95% CI 1.12, 1.68; p <.01) and overall mortality (HR per SD 1.24; 95% CI 1.09, 1.41; p <.01).Conclusion: hsTnI as a biomarker of myocardial injury does not improve prediction of AF incidence beyond classical CVRF and NT-proBNP. However, it is associated with the AF-related disease heart failure and mortality likely reflecting underlying subclinical cardiovascular impairment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- atrial fibrillation
- biomarkers
- epidemiology
- high-sensitivity troponin I
- N-terminal pro B-type natriuretic peptide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Börschel, Christ ...
-
Geelhoed, Bastia ...
-
Niiranen, Teemu
-
Camen, Stephan
-
Donati, Maria Be ...
-
Havulinna, Aki S ...
-
visa fler...
-
Gianfagna, Franc ...
-
Palosaari, Tarja
-
Jousilahti, Pekk ...
-
Kontto, Jukka
-
Vartiainen, Erkk ...
-
Ojeda, Francisco ...
-
den Ruijter, Hes ...
-
Costanzo, Simona
-
de Gaetano, Giov ...
-
Di Castelnuovo, ...
-
Linneberg, Allan
-
Vishram-Nielsen, ...
-
Løchen, Maja-Lis ...
-
Koenig, Wolfgang
-
Jørgensen, Torbe ...
-
Kuulasmaa, Kari
-
Blankenberg, Ste ...
-
Iacoviello, Lici ...
-
Zeller, Tanja
-
Söderberg, Stefa ...
-
Salomaa, Veikko
-
Schnabel, Renate ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Umeå universitet