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A cross-sectional s...
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium
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- Midttun, Øivind (author)
- Bevital AS, Laboratory Building, Bergen, Norway
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- Ulvik, Arve (author)
- Bevital AS, Laboratory Building, Bergen, Norway
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- Meyer, Klaus (author)
- Bevital AS, Laboratory Building, Bergen, Norway
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- Zahed, Hana (author)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Giles, Graham G. (author)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Sandsveden, Malte (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Langhammer, Arnulf (author)
- Department of Public Health and Nursing, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
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- Sørgjerd, Elin Pettersen (author)
- Department of Public Health and Nursing, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Levanger, Norway
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- Behndig, Annelie F., 1963- (author)
- Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Johansson, Mikael (author)
- Umeå University,Umeå universitet,Onkologi,Brigham and Women's Hospital / Harvard Medical School,Boston Veteran's Administration (VA) Healthcare
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- Freedman, Neal D. (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Huang, Wen-Yi (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Chen, Chu (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, United States,Fred Hutchinson Cancer Research Center
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- Prentice, Ross (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, United States,Fred Hutchinson Cancer Research Center
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- Stevens, Victoria L. (author)
- American Cancer Society, Atlanta, United States
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- Wang, Ying (author)
- American Cancer Society, Atlanta, United States
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- Le Marchand, Loïc (author)
- University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, United States
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- Weinstein, Stephanie J. (author)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Cai, Qiuyin (author)
- Vanderbilt University Medical Center, Nashville, United States
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- Arslan, Alan A. (author)
- Department of Obstetrics and Gynecology, NYU Langone Health, New York, NY, USA; Department of Population Health, NYU Langone Health, New York, NY, USA; Perlmutter Comprehensive Cancer Center, NYU Langone Health, New York, NY, USA,International Agency for Research on Cancer, World Health Organization
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- Chen, Yu (author)
- Department of Population Health, NYU Langone Health, New York, NY, USA; Perlmutter Comprehensive Cancer Center, NYU Langone Health, New York, NY, USA
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- Shu, Xiao-Ou (author)
- Department of Population Health, NYU Langone Health, New York, NY, USA
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- Zheng, Wei (author)
- Department of Population Health, NYU Langone Health, New York, NY, USA
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- Yuan, Jian-Min (author)
- University of Pittsburgh and UPMC Hillman Cancer Center, Pittsburgh, United States,University of Pittsburgh Cancer Institute
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- Koh, Woon-Puay (author)
- Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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- Visvanathan, Kala (author)
- Johns Hopkins Institute for Clinical and Translational Research, Baltimore, United States,Johns Hopkins University
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- Sesso, Howard D. (author)
- Brigham and Women's Hospital, Harvard Medical School, Boston, United States; Harvard T.H. Chan School of Public Health, Boston, United States,Harvard University
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- Zhang, Xuehong (author)
- Brigham and Women's Hospital, Harvard Medical School, Boston, United States; Harvard T.H. Chan School of Public Health, Boston, United States,Harvard University
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- Gaziano, J. Michael (author)
- Brigham and Women's Hospital, Boston, United States; VA Boston Healthcare System, MA, Boston, United States
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- Fanidi, Anouar (author)
- Université Claude Bernard Lyon 1, Lyon, France
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- Robbins, Hilary A. (author)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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- Brennan, Paul (author)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (author)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Ueland, Per M. (author)
- Bevital AS, Laboratory Building, Bergen, Norway
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(creator_code:org_t)
- 2023-01-18
- 2023
- English.
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In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
- Related links:
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https://doi.org/10.1...
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Abstract
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- Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin and the kynurenine/tryptophan ratio (KTR) are IFN-γ induced inflammatory markers, and together with C-reactive protein (CRP) and kynurenines they are associated with various diseases, but comprehensive data on the strength of associations of inflammatory markers with circulating concentrations of kynurenines are lacking. We measured circulating concentrations of neopterin, CRP, tryptophan and seven kynurenines in 5314 controls from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). The associations of neopterin, KTR and CRP with kynurenines were investigated using regression models. In mixed models, one standard deviation (SD) higher KTR was associated with a 0.46 SD higher quinolinic acid (QA), and 0.31 SD higher 3-hydroxykynurenine (HK). One SD higher neopterin was associated with 0.48, 0.44, 0.36 and 0.28 SD higher KTR, QA, kynurenine and HK, respectively. KTR and neopterin respectively explained 24.1% and 16.7% of the variation in QA, and 11.4% and 7.5% of HK. CRP was only weakly associated with kynurenines in regression models. In summary, QA was the metabolite that was most strongly associated with the inflammatory markers. In general, the inflammatory markers were most strongly related to metabolites located along the tryptophan-NAD axis, which may support suggestions of increased production of NAD from tryptophan during inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Midttun, Øivind
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Ulvik, Arve
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Meyer, Klaus
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Zahed, Hana
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Giles, Graham G.
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Manjer, Jonas
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show more...
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Sandsveden, Malt ...
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Langhammer, Arnu ...
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Sørgjerd, Elin P ...
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Behndig, Annelie ...
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Johansson, Mikae ...
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Freedman, Neal D ...
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Huang, Wen-Yi
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Chen, Chu
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Prentice, Ross
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Stevens, Victori ...
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Wang, Ying
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Le Marchand, Loï ...
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Weinstein, Steph ...
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Cai, Qiuyin
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Arslan, Alan A.
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Chen, Yu
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Shu, Xiao-Ou
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Zheng, Wei
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Yuan, Jian-Min
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Koh, Woon-Puay
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Visvanathan, Kal ...
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Sesso, Howard D.
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Zhang, Xuehong
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Gaziano, J. Mich ...
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Fanidi, Anouar
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Robbins, Hilary ...
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Brennan, Paul
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Johansson, Matti ...
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Ueland, Per M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Umeå University
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Lund University