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Dietary intake of t...
Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study
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- Aglago, Elom K. (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom,International Agency for Research on Cancer, World Health Organization
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- Cross, Amanda J. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom,International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Fedirko, Veronika (author)
- Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Hughes, David J. (author)
- Cancer Biology and Therapeutics Group (CBT), Conway Institute, School of Biomolecular and Biomedical Science (SBBS), University College Dublin, Dublin, Ireland
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- Fournier, Agnes (author)
- Centre de Recherche en Epidémiologie et Santé des Populations, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Villejuif, France
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- Jakszyn, Paula (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
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- Freisling, Heinz (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc J. (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark,International Agency for Research on Cancer, World Health Organization
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- Overvad, Kim (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Kyrø, Cecilie (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Boutron-Ruault, Marie-Christine (author)
- Centre de Recherche en Epidémiologie et Santé des Populations, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Villejuif, France
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- Rothwell, Joseph A. (author)
- Centre de Recherche en Epidémiologie et Santé des Populations, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Villejuif, France
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- Severi, Gianluca (author)
- Centre de Recherche en Epidémiologie et Santé des Populations, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti”, University of Florence, Florence, Italy
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- Katzke, Verena (author)
- Division of Cancer Epidemiology, German Cancer research Center (DKFZ), Heidelberg, Germany
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- Srour, Bernard (author)
- Division of Cancer Epidemiology, German Cancer research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Wittenbecher, Clemens (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; German Center for Diabetes Research (DZD), Neuherberg, Germany,Harvard University
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- Palli, Domenico (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy
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- Sieri, Sabina (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian, Milano, Italy
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- Pasanisi, Fabrizio (author)
- Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy,Azienda Ospedaliera Universitaria Federico II
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- Tumino, Rosario (author)
- Hyblean Association for Epidemiological Research, AIRE-ONLUS, Ragusa, Italy
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- Ricceri, Fulvio (author)
- Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; Unit of Epidemiology, Regional Health Service, TO, Grugliasco, Italy
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- Bueno-de-Mesquita, Bas (author)
- Former senior scientist, Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven, Netherlands
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- Derksen, Jeroen W. G. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Skeie, Guri (author)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway,UiT The Arctic University of Norway, Tromsø
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- Jensen, Torill Enget (author)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway,UiT The Arctic University of Norway, Tromsø
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- Lukic, Marko (author)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway,UiT The Arctic University of Norway, Tromsø
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- Sánchez, Maria-Jose (author)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Amiano, Pilar (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Epidemiology and Public Health Area, San Sebastián, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Colorado-Yohar, Sandra (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia,CIBER Epidemiology and Public Health (CIBERESP)
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- Barricarte, Aurelio (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- van Guelpen, Bethany (author)
- Umeå University,Umeå universitet,Institutionen för strålningsvetenskaper,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Papier, Keren (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Knuppel, Anika (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Casagrande, Corinne (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Huybrechts, Inge (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Heath, Alicia K. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Tsilidis, Konstantinos K. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Jenab, Mazda (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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(creator_code:org_t)
- 2023-02-09
- 2023
- English.
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In: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 128, s. 1529-1540
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.Methods: We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.Results: Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q1:0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q1:0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q1:1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q1:1.11, 95%CI:0.94, 1.31), heme (HRQ5vs.Q1:0.95; 95%CI:0.84, 1.07) or non-heme iron (HRQ5vs.Q1:1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99).Conclusions: Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Aglago, Elom K.
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Cross, Amanda J.
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Riboli, Elio
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Fedirko, Veronik ...
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Hughes, David J.
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Fournier, Agnes
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Jakszyn, Paula
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Freisling, Heinz
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Gunter, Marc J.
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Dahm, Christina ...
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Overvad, Kim
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Tjønneland, Anne
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Kyrø, Cecilie
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Boutron-Ruault, ...
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Rothwell, Joseph ...
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Severi, Gianluca
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Katzke, Verena
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Srour, Bernard
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Schulze, Matthia ...
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Wittenbecher, Cl ...
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Palli, Domenico
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Sieri, Sabina
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Pasanisi, Fabriz ...
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Tumino, Rosario
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Ricceri, Fulvio
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Bueno-de-Mesquit ...
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Derksen, Jeroen ...
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Skeie, Guri
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Jensen, Torill E ...
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Lukic, Marko
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Sánchez, Maria-J ...
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Amiano, Pilar
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Colorado-Yohar, ...
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Barricarte, Aure ...
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Ericson, Ulrika
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van Guelpen, Bet ...
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Papier, Keren
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Knuppel, Anika
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Casagrande, Cori ...
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Huybrechts, Inge
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Heath, Alicia K.
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Tsilidis, Konsta ...
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Jenab, Mazda
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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British Journal ...
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Umeå University
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Lund University