SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Taghon Tom)
 

Sökning: WFRF:(Taghon Tom) > Pre-clinical evalua...

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of t-cell lymphoblastic lymphoma

Provez, Lien (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Putteman, Tom (författare)
Taghon Laboratory, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Landfors, Mattias, 1977- (författare)
Umeå universitet,Patologi
visa fler...
Roels, Juliette (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Taghon Laboratory, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Reunes, Lindy (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
T’Sas, Sara (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Unit for Translational Research in Oncology, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Van Loocke, Wouter (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Lintermans, Béatrice (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
De Coninck, Stien (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Thenoz, Morgan (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Sleeckx, Wouter (författare)
Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Unit for Translational Research in Oncology, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium; Hematology Department, Ghent University Hospital (UZGent), Ghent, Belgium
Maćkowska-Maślak, Natalia (författare)
Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland
Taghon, Tom (författare)
Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Taghon Laboratory, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Mansour, Marc R. (författare)
Leukaemia Biology Research Group, Department of Heamatology, University College London Cancer Institute, London, United Kingdom; UCL Great Ormond Street Institute of Child Health, London, United Kingdom
Farah, Nadine (författare)
Leukaemia Biology Research Group, Department of Heamatology, University College London Cancer Institute, London, United Kingdom
Norga, Koen (författare)
Paediatric Oncology at Antwerp University, Antwerp, Belgium
Vandenberghe, Peter (författare)
Department of Human Genetics, Leuven University, Leuven, Belgium
Kotecha, Rishi S. (författare)
Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children’s Hospital, Perth, Australia; Curtin Medical School, Curtin University, Perth, Australia
Goossens, Steven (författare)
Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Unit for Translational Research in Oncology, Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
Degerman, Sofie, 1977- (författare)
Umeå universitet,Institutionen för klinisk mikrobiologi,Patologi
De Smedt, Renate (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Van Vlierberghe, Pieter (författare)
Normal and Malignant Hematopoiesis Laboratory, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
visa färre...
 (creator_code:org_t)
2023-01-20
2023
Engelska.
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 15:3
Relaterad länk:
https://doi.org/10.3...
visa fler...
https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed at a young age. Patients are treated with intensive chemotherapy, potentially followed by a hematopoietic stem cell transplantation. Although prognosis of T-LBL has improved with intensified treatment protocols, they are associated with side effects and 10–20% of patients still die from relapsed or refractory disease. Given this, the search toward less toxic anti-lymphoma therapies is ongoing. Here, we targeted the recently described DNA hypermethylated profile in T-LBL with the DNA hypomethylating agent decitabine. We evaluated the anti-lymphoma properties and downstream effects of decitabine, using patient derived xenograft (PDX) models. Decitabine treatment resulted in prolonged lymphoma-free survival in all T-LBL PDX models, which was associated with downregulation of the oncogenic MYC pathway. However, some PDX models showed more benefit of decitabine treatment compared to others. In more sensitive models, differentially methylated CpG regions resulted in more differentially expressed genes in open chromatin regions. This resulted in stronger downregulation of cell cycle genes and upregulation of immune response activating transcripts. Finally, we suggest a gene signature for high decitabine sensitivity in T-LBL. Altogether, we here delivered pre-clinical proof of the potential use of decitabine as a new therapeutic agent in T-LBL.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

decitabine
DNA methylation
T-LBL

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

  • Cancers (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy