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- Andersson, JohnUmeå universitet,Institutionen för psykologi (author)
Pm2.5 and dementia in a low exposure setting : the influence of odor identification ability and APOE
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- IOS Press,2023
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-205123
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205123URI
- https://doi.org/10.3233/jad-220469DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- Background: Growing evidence show that long term exposure to air pollution increases the risk of dementia.Objective: The aim of this study was to investigate associations between PM2.5 exposure and dementia in a low exposure area, and to investigate the role of olfaction and the APOE ε4 allele in these associations.Methods: Data were drawn from the Betula project, a longitudinal study on aging, memory, and dementia in Sweden. Odor identification ability was assessed using the Scandinavian Odor Identification Test (SOIT). Annual mean PM2.5 concentrations were obtained from a dispersion-model and matched at the participants’ residential address. Proportional hazard regression was used to calculate hazard ratios.Results: Of 1,846 participants, 348 developed dementia during the 21-year follow-up period. The average annual mean PM2.5 exposure at baseline was 6.77 µg/m3, which is 1.77 µg/m3 above the WHO definition of clean air. In a fully adjusted model (adjusted for age, sex, APOE, SOIT, cardiovascular diseases and risk factors, and education) each 1 µg/m3 difference in annual mean PM2.5-concentration was associated with a hazard ratio of 1.23 for dementia (95% CI: 1.01–1.50). Analyses stratified by APOE status (ε4 carriers versus non-carriers), and odor identification ability (high versus low), showed associations only for ε4 carriers, and for low performance on odor identification ability.Conclusion: PM2.5 was associated with an increased risk of dementia in this low pollution setting. The associations between PM2.5 and dementia seemed stronger in APOE carriers and those with below average odor identification ability.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
- Alzheimer’s disease
- Apolipoprotein E
- olfaction
- particulate matter
- vascular dementia
- Psychology
- psykologi
- Occupational and Environmental Medicine
- arbets- och miljömedicin
Added entries (persons, corporate bodies, meetings, titles ...)
- Sundström, AnnaUmeå universitet,Institutionen för psykologi,Enheten för demografi och åldrandeforskning (CEDAR),Department of Research and Development, Sundsvall Hospital, Sundsvall, Sweden(Swepub:umu)ansu0001 (author)
- Nordin, MariaUmeå universitet,Institutionen för psykologi(Swepub:umu)nonmaa98 (author)
- Segersson, DavidSwedish Meteorological and Hydrological Institute (SMHI), Norrköping, Sweden (author)
- Forsberg, Bertil,professor,1956-Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)befo0001 (author)
- Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (author)
- Oudin, AnnaUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden(Swepub:umu)anou0004 (author)
- Umeå universitetInstitutionen för psykologi (creator_code:org_t)
Related titles
- In:Journal of Alzheimer's Disease: IOS Press92:2, s. 679-6891387-28771875-8908
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