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  • Karavasiloglou, NenaNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland (författare)

Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-205187
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205187URI
  • https://doi.org/10.1016/j.ajcnut.2022.10.004DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum.CONCLUSIONS: In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hughes, David J.Cancer Biology and Therapeutics Group, UCD Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland (författare)
  • Murphy, NeilNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France (författare)
  • Schomburg, LutzInstitut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Sun, QianInstitut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Seher, VartiterInstitut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany (författare)
  • Rohrmann, SabineDivision of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland (författare)
  • Weiderpass, ElisabeteOffice of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France (författare)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; University of Copenhagen, Department of Public Health, Copenhagen, Denmark (författare)
  • Olsen, AnjaDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; University of Århus, Department of Public Health, Århus, Denmark (författare)
  • Overvad, KimUniversity of Århus, Department of Public Health, Århus, Denmark (författare)
  • Boutron-Ruault, Marie-ChristineCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France (författare)
  • Mancini, Francesca RomanaCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France (författare)
  • Mahamat-Saleh, YahyaCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Kuhn, TilmanDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Biological Sciences, Queens University of Belfast, Belfast, Northern Ireland (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (författare)
  • Tumino, RosarioHyblean Association for Epidemiology Research, Italy (författare)
  • Panico, SalvatoreDipartimento Di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (författare)
  • Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (författare)
  • Pala, ValeriaEpidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy (författare)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy (författare)
  • Derksen, Jeroen W GJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
  • Skeie, GuriDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Norway (författare)
  • Hjartåker, AnetteDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway (författare)
  • Lasheras, CristinaDepartment of Functional Biology, Faculty of Medicine, University of Oviedo, Asturias, Spain (författare)
  • Agudo, AntonioUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (författare)
  • Sánchez, Maria-JoséEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (författare)
  • Chirlaque, Maria-DoloresCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Spain (författare)
  • Ardanaz, EvaCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (författare)
  • Amiano, PilarCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain (författare)
  • van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (författare)
  • Gylling, Björn,1978-Umeå universitet,Patologi(Swepub:umu)bjgy0001 (författare)
  • Bradbury, Kathryn E.National Institute for Health Innovation, University of Auckland, New Zealand (författare)
  • Papier, KerenCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Freisling, HeinzNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France (författare)
  • Aglago, Elom K.Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom (författare)
  • Cross, Amanda J.Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom (författare)
  • Riboli, ElioDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom (författare)
  • Aune, DagfinnDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom (författare)
  • Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France (författare)
  • Jenab, MazdaNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France (författare)
  • Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, SwitzerlandCancer Biology and Therapeutics Group, UCD Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Clinical Nutrition: Elsevier117:1, s. 33-450002-91651938-3207

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