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Sökning: WFRF:(Esmail E) > (2020-2023) > Accelerated epigene...

  • Boström, Adrian Desai E.Umeå universitet,Psykiatri,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden,Umea Univ, Dept Clin Sci, Psychiat, Umea, Sweden.;Karolinska Univ Hosp, Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm Hlth Care Serv, SE-17176 Stockholm, Sweden. (författare)

Accelerated epigenetic aging in women with emotionally unstable personality disorder and a history of suicide attempts

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-02-22
  • Nature Publishing Group,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-205493
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205493URI
  • https://doi.org/10.1038/s41398-023-02369-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-499217URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152053809URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Emotional unstable personality disorder (EUPD; previously borderline personality disorder, BPD) is associated with excess natural-cause mortality, comorbid medical conditions, poor health habits and stress related epigenomic alterations. Previous studies demonstrated that GrimAge – a state-of-the-art epigenetic age (EA) estimator – strongly predicts mortality risk and physiological dysregulation. Herein, we utilize the GrimAge algorithm to investigate whether women with EUPD and a history of recent suicide attempts exhibit EA acceleration (EAA) in comparison to healthy controls. Genome-wide methylation patterns were measured using the Illumina Infinum Methylation Epic BeadChip in whole blood from 97 EUPD patients and 32 healthy controls. The control group was significantly older (p < 0.0001) and reported lesser exposure to violent behavior in both youth and adulthood (p < 0.0001). Groups were otherwise comparable regarding gender, BMI, or tobacco usage (p > 0.05). EA estimator DNAmGrimAge exceeded chronological age by 8.8 and 2.3 years in the EUPD and control group, respectively. Similarly, EAA marker AgeAccelGrim was substantially higher in EUPD subjects when compared to controls, in both univariate and multivariate analyzes (p < 0.00001). Tobacco usage conferred substantial within-group effects on the EA-chronological age difference, i.e., 10.74 years (SD = 4.19) compared to 6.00 years (SD = 3.10) in the non-user EUPD group (p < 0.00001). Notably, past alcohol and substance abuse, use of psychotropic medications, global assessment of functioning, self-reported exposure to violent behavior in youth and adulthood, later completed suicide (N = 8) and age at first suicide attempt did not predict EAA in the EUPD group (p > 0.05). These results underscore the importance of addressing medical health conditions along with low-cost preventative interventions aimed at improving somatic health outcomes in EUPD, such as efforts to support cessation of tobacco use. The independency of GrimAge to other EA algorithms in this group of severely impaired EUPD patients, suggest it may have unique characteristics to evaluate risk of adverse health outcomes in context of psychiatric disorders.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Andersson, PeterKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning Dalarna,Karolinska Inst, Dept Clin Neurosci, Psychol, Stockholm, Sweden.;Uppsala Univ, Ctr Clin Res Dalarna, Falun, Sweden.(Swepub:uu)petan213 (författare)
  • Jamshidi, EsmailUmeå universitet,Psykiatri,Umea Univ, Dept Clin Sci, Psychiat, Umea, Sweden.(Swepub:umu)esja0010 (författare)
  • Wilczek, AlexanderKarolinska Institutet (författare)
  • Nilsonne, ÅsaDepartment of Clinical Sciences, Karolinska Institutet at Danderyd Hospital, Stockholm, Sweden,Karolinska Inst Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden. (författare)
  • Rask-Andersen, MathiasDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Uppsala, Sweden. (författare)
  • Åsberg, MarieKarolinska Institutet (författare)
  • Jokinen, JussiKarolinska Institutet,Umeå universitet,Psykiatri,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden,Umea Univ, Dept Clin Sci, Psychiat, Umea, Sweden.;Karolinska Univ Hosp, Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm Hlth Care Serv, SE-17176 Stockholm, Sweden.(Swepub:umu)jujo0022 (författare)
  • Umeå universitetPsykiatri (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Translational Psychiatry: Nature Publishing Group13:12158-3188

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