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  • Rothwell, Joseph A.Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France (författare)

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-02-28
  • BioMed Central (BMC),2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-205643
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205643URI
  • https://doi.org/10.1186/s12916-023-02739-4DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bešević, JelenaCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Dimou, NikiInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Breeur, MarieInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Murphy, NeilInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Wedekind, RolandInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Viallon, VivianInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Ferrari, PietroInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Achaintre, DavidInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Gicquiau, AudreyInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Rinaldi, SabinaInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Scalbert, AugustinInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Huybrechts, IngeInternational Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Prehn, CorneliaMetabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany (författare)
  • Adamski, JerzyDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, Singapore; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia (författare)
  • Cross, Amanda J.School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Keun, HectorDepartment of Surgery & Cancer, Imperial College London, London, United Kingdom (författare)
  • Chadeau-Hyam, MarcSchool of Public Health, Imperial College London, London, United Kingdom (författare)
  • Boutron-Ruault, Marie-ChristineCentre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France (författare)
  • Overvad, KimDepartment of Public Health, Aarhus University, Bartholins Allé 2, Aarhus, Denmark (författare)
  • Dahm, Christina C.Department of Public Health, Aarhus University, Bartholins Allé 2, Aarhus, Denmark (författare)
  • Nøst, Therese HaugdahlFaculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway (författare)
  • Sandanger, Torkjel M.Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway (författare)
  • Skeie, GuriFaculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway (författare)
  • Zamora-Ros, RaulUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain (författare)
  • Tsilidis, Kostas K.School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece (författare)
  • Eichelmann, FabianGerman Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany (författare)
  • van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (författare)
  • Vidman, LindaUmeå universitet,Onkologi(Swepub:umu)livi0018 (författare)
  • Sánchez, Maria-JoséEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (författare)
  • Amiano, PilarMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain (författare)
  • Ardanaz, EvaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Leyre 15, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (författare)
  • Smith-Byrne, KarlCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France (författare)
  • Travis, RuthCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Katzke, VerenaGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany (författare)
  • Kaaks, RudolfGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany (författare)
  • Derksen, Jeroen W. G.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
  • Colorado-Yohar, SandraCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (författare)
  • Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy (författare)
  • Bueno-de-Mesquita, BasDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, BA, Bilthoven, Netherlands (författare)
  • Vineis, PaoloSchool of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy (författare)
  • Pasanisi, FabrizioDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (författare)
  • Eriksen, Anne KirstineDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark (författare)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, Copenhagen, Denmark (författare)
  • Severi, GianlucaCentre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Florence, Italy (författare)
  • Gunter, Marc J.International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France; School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, FranceCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Medicine: BioMed Central (BMC)21:11741-7015

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