The association between familial risk and brain abnormalities is disease specific: an ENIGMA-relatives study of schizophrenia and bipolar disorder

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Fältnamn	Indikatorer	Metadata
000		07833naa a2201549 4500
001		oai:DiVA.org:umu-206300
003		SwePub
008		230404s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:141845725
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2063002 URI
024	7	a https://doi.org/10.1016/j.biopsych.2019.03.9852 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1418457252 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a de Zwarte, Sonja M. C.4 aut
245	1 0	a The association between familial risk and brain abnormalities is disease specific :b an ENIGMA-relatives study of schizophrenia and bipolar disorder
264	1	b Elsevier,c 2019
338		a electronic2 rdacarrier
520		a BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects.CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653		a Bipolar disorder
653		a Familial risk
653		a Imaging
653		a Meta-analysis
653		a Neurodevelopment
653		a Schizophrenia
700	1	a Brouwer, Rachel M.4 aut
700	1	a Agartz, Ingridu Karolinska Institutet4 aut
700	1	a Alda, Martin4 aut
700	1	a Aleman, André4 aut
700	1	a Alpert, Kathryn I.4 aut
700	1	a Bearden, Carrie E.4 aut
700	1	a Bertolino, Alessandro4 aut
700	1	a Bois, Catherine4 aut
700	1	a Bonvino, Aurora4 aut
700	1	a Bramon, Elvira4 aut
700	1	a Buimer, Elizabeth E. L.4 aut
700	1	a Cahn, Wiepke4 aut
700	1	a Cannon, Dara M.4 aut
700	1	a Cannon, Tyrone D.4 aut
700	1	a Caseras, Xavier4 aut
700	1	a Castro-Fornieles, Josefina4 aut
700	1	a Chen, Qiang4 aut
700	1	a Chung, Yoonho4 aut
700	1	a De la Serna, Elena4 aut
700	1	a Di Giorgio, Annabella4 aut
700	1	a Doucet, Gaelle E.4 aut
700	1	a Eker, Mehmet Cagdas4 aut
700	1	a Erk, Susanne4 aut
700	1	a Fears, Scott C.4 aut
700	1	a Foley, Sonya F.4 aut
700	1	a Frangou, Sophia4 aut
700	1	a Frankland, Andrew4 aut
700	1	a Fullerton, Janice M.4 aut
700	1	a Glahn, David C.4 aut
700	1	a Goghari, Vina M.4 aut
700	1	a Goldman, Aaron L.4 aut
700	1	a Gonul, Ali Saffet4 aut
700	1	a Gruber, Oliver4 aut
700	1	a de Haan, Lieuwe4 aut
700	1	a Hajek, Tomas4 aut
700	1	a Hawkins, Emma L.4 aut
700	1	a Heinz, Andreas4 aut
700	1	a Hillegers, Manon H. J.4 aut
700	1	a Hulshoff Pol, Hilleke E.4 aut
700	1	a Hultman, Christina M.4 aut
700	1	a Ingvar, Martinu Karolinska Institutet4 aut
700	1	a Johansson, Viktoriau Karolinska Institutet4 aut0 (Swepub:umu)vijo2972
700	1	a Jönsson, Erik G.u Karolinska Institutet4 aut
700	1	a Kane, Fergus4 aut
700	1	a Kempton, Matthew J.4 aut
700	1	a Koenis, Marinka M. G.4 aut
700	1	a Kopecek, Miloslav4 aut
700	1	a Krabbendam, Lydia4 aut
700	1	a Krämer, Bernd4 aut
700	1	a Lawrie, Stephen M.4 aut
700	1	a Lenroot, Rhoshel K.4 aut
700	1	a Marcelis, Machteld4 aut
700	1	a Marsman, Jan-Bernard C.4 aut
700	1	a Mattay, Venkata S.4 aut
700	1	a McDonald, Colm4 aut
700	1	a Meyer-Lindenberg, Andreas4 aut
700	1	a Michielse, Stijn4 aut
700	1	a Mitchell, Philip B.4 aut
700	1	a Moreno, Dolores4 aut
700	1	a Murray, Robin M.4 aut
700	1	a Mwangi, Benson4 aut
700	1	a Najt, Pablo4 aut
700	1	a Neilson, Emma4 aut
700	1	a Newport, Jason4 aut
700	1	a van Os, Jim4 aut
700	1	a Overs, Bronwyn4 aut
700	1	a Ozerdem, Aysegul4 aut
700	1	a Picchioni, Marco M.4 aut
700	1	a Richter, Anja4 aut
700	1	a Roberts, Gloria4 aut
700	1	a Aydogan, Aybala Saricicek4 aut
700	1	a Schofield, Peter R.4 aut
700	1	a Simsek, Fatma4 aut
700	1	a Soares, Jair C.4 aut
700	1	a Sugranyes, Gisela4 aut
700	1	a Toulopoulou, Timothea4 aut
700	1	a Tronchin, Giulia4 aut
700	1	a Walter, Henrik4 aut
700	1	a Wang, Lei4 aut
700	1	a Weinberger, Daniel R.4 aut
700	1	a Whalley, Heather C.4 aut
700	1	a Yalin, Nefize4 aut
700	1	a Andreassen, Ole A.4 aut
700	1	a Ching, Christopher R. K.4 aut
700	1	a van Erp, Theo G. M.4 aut
700	1	a Turner, Jessica A.4 aut
700	1	a Jahanshad, Neda4 aut
700	1	a Thompson, Paul M.4 aut
700	1	a Kahn, René S.4 aut
700	1	a van Haren, Neeltje E. M.4 aut
710	2	a Karolinska Institutet4 org
773	0	t Biological Psychiatryd : Elsevierg 86:7, s. 545-556q 86:7<545-556x 0006-3223x 1873-2402
856	4	u https://doi.org/10.1016/j.biopsych.2019.03.985y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1748808/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.biologicalpsychiatryjournal.com/article/S0006322319314374/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206300
856	4 8	u https://doi.org/10.1016/j.biopsych.2019.03.985
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:141845725

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By the author/editor: de Zwarte, Sonja ...; Brouwer, Rachel ...; Agartz, Ingrid; Alda, Martin; Aleman, André; Alpert, Kathryn ...; show more...; Bearden, Carrie ...; Bertolino, Aless ...; Bois, Catherine; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabet ...; Cahn, Wiepke; Cannon, Dara M.; Cannon, Tyrone D ...; Caseras, Xavier; Castro-Fornieles ...; Chen, Qiang; Chung, Yoonho; De la Serna, Ele ...; Di Giorgio, Anna ...; Doucet, Gaelle E ...; Eker, Mehmet Cag ...; Erk, Susanne; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Frankland, Andre ...; Fullerton, Janic ...; Glahn, David C.; Goghari, Vina M.; Goldman, Aaron L ...; Gonul, Ali Saffe ...; Gruber, Oliver; de Haan, Lieuwe; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hillegers, Manon ...; Hulshoff Pol, Hi ...; Hultman, Christi ...; Ingvar, Martin; Johansson, Vikto ...; Jönsson, Erik G.; Kane, Fergus; Kempton, Matthew ...; Koenis, Marinka ...; Kopecek, Milosla ...; Krabbendam, Lydi ...; Krämer, Bernd; Lawrie, Stephen ...; Lenroot, Rhoshel ...; Marcelis, Machte ...; Marsman, Jan-Ber ...; Mattay, Venkata ...; McDonald, Colm; Meyer-Lindenberg ...; Michielse, Stijn; Mitchell, Philip ...; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Najt, Pablo; Neilson, Emma; Newport, Jason; van Os, Jim; Overs, Bronwyn; Ozerdem, Aysegul; Picchioni, Marco ...; Richter, Anja; Roberts, Gloria; Aydogan, Aybala ...; Schofield, Peter ...; Simsek, Fatma; Soares, Jair C.; Sugranyes, Gisel ...; Toulopoulou, Tim ...; Tronchin, Giulia; Walter, Henrik; Wang, Lei; Weinberger, Dani ...; Whalley, Heather ...; Yalin, Nefize; Andreassen, Ole ...; Ching, Christoph ...; van Erp, Theo G. ...; Turner, Jessica ...; Jahanshad, Neda; Thompson, Paul M ...; Kahn, René S.; van Haren, Neelt ...; show less...

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