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Prediagnostic serum...
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Mao, ZilingDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
(author)
Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-20
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John Wiley & Sons,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-206343
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206343URI
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https://doi.org/10.1002/ijc.34449DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Baker, Jacqueline RoshelliDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
(author)
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Takeuchi, MasayoshiDepartment of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan
(author)
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Hyogo, HideyukiDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan; Lifecare Clinic Hiroshima, Hiroshima, Japan
(author)
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Tjønneland, AnneDanish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
(author)
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Eriksen, Anne KirstineDanish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark
(author)
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Severi, GianlucaUVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science Applications, “G. Parenti” University of Florence, Florence, Italy
(author)
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Rothwell, JosephUVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France
(author)
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Laouali, NasserUVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France
(author)
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Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
(author)
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Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy
(author)
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Sieri, SabinaEpidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy
(author)
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de Magistris, Maria SantucciAzienda Ospedaliera Universitaria Federico II, Naples, Italy
(author)
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Tumino, RosarioHyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy
(author)
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Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
(author)
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Derksen, Jeroen W. G.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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Gram, Inger T.Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
(author)
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Skeie, GuriDepartment of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
(author)
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Sandanger, Torkjel M.Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
(author)
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Quirós, Jose RamónPublic Health Directorate, Asturias, Spain
(author)
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Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
(author)
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Sánchez, Maria-JoseEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
(author)
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Amiano, PilarSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
(author)
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Colorado-Yohar, Sandra M.Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
(author)
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Guevara, MarcelaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
(author)
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Harlid, Sophia,1978-Umeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)soha0105
(author)
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Johansson, IngegerdUmeå universitet,Institutionen för odontologi(Swepub:umu)injo0003
(author)
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Perez-Cornago, AuroraCancer Epidemiology Unit (CEU), Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
(author)
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Freisling, HeinzSection of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
(author)
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Gunter, MarcSection of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
(author)
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Weiderpass, ElisabeteOffice of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Aglago, ElomDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
(author)
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Jenab, MazdaSection of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
(author)
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Fedirko, VeronikaDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; MD Anderson Cancer Center, TX, Houston, United States
(author)
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Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United StatesDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
(creator_code:org_t)
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In:International Journal of Cancer: John Wiley & Sons152:11, s. 2257-22680020-71361097-0215
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Mao, Ziling
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Baker, Jacquelin ...
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Takeuchi, Masayo ...
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Hyogo, Hideyuki
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Tjønneland, Anne
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Severi, Gianluca
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Palli, Domenico
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Gram, Inger T.
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Guevara, Marcela
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Harlid, Sophia, ...
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