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  • Mao, ZilingDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States (author)

Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-20
  • John Wiley & Sons,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-206343
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206343URI
  • https://doi.org/10.1002/ijc.34449DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.

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  • Baker, Jacqueline RoshelliDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States (author)
  • Takeuchi, MasayoshiDepartment of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan (author)
  • Hyogo, HideyukiDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan; Lifecare Clinic Hiroshima, Hiroshima, Japan (author)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark (author)
  • Eriksen, Anne KirstineDanish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark (author)
  • Severi, GianlucaUVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science Applications, “G. Parenti” University of Florence, Florence, Italy (author)
  • Rothwell, JosephUVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France (author)
  • Laouali, NasserUVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France (author)
  • Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (author)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (author)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy (author)
  • Sieri, SabinaEpidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy (author)
  • de Magistris, Maria SantucciAzienda Ospedaliera Universitaria Federico II, Naples, Italy (author)
  • Tumino, RosarioHyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy (author)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy (author)
  • Derksen, Jeroen W. G.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (author)
  • Gram, Inger T.Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway (author)
  • Skeie, GuriDepartment of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway (author)
  • Sandanger, Torkjel M.Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway (author)
  • Quirós, Jose RamónPublic Health Directorate, Asturias, Spain (author)
  • Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (author)
  • Sánchez, Maria-JoseEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (author)
  • Amiano, PilarSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain (author)
  • Colorado-Yohar, Sandra M.Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (author)
  • Guevara, MarcelaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain (author)
  • Harlid, Sophia,1978-Umeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)soha0105 (author)
  • Johansson, IngegerdUmeå universitet,Institutionen för odontologi(Swepub:umu)injo0003 (author)
  • Perez-Cornago, AuroraCancer Epidemiology Unit (CEU), Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom (author)
  • Freisling, HeinzSection of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France (author)
  • Gunter, MarcSection of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France (author)
  • Weiderpass, ElisabeteOffice of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France (author)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Aglago, ElomDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Jenab, MazdaSection of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France (author)
  • Fedirko, VeronikaDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; MD Anderson Cancer Center, TX, Houston, United States (author)
  • Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United StatesDepartment of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States (creator_code:org_t)

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  • In:International Journal of Cancer: John Wiley & Sons152:11, s. 2257-22680020-71361097-0215

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