Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite : Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite : Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Sanikini, Harinakshi (författare): Imperial College London

Muller, David C. (författare): Imperial College London

Sophiea, Marisa (författare): Imperial College London

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Rinaldi, Sabina (författare): International Agency for Research on Cancer, World Health Organization

Agudo, Antonio (författare): Catalan Institute of Oncology

Duell, Eric J. (författare): Catalan Institute of Oncology

Weiderpass, Elisabete (författare): Karolinska Institutet,Karolinska Institute,University of Helsinki,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research

Overvad, Kim (författare): Aarhus University

Tjønneland, Anne (författare): Danish Cancer Society

Halkjær, Jytte (författare): Danish Cancer Society

Boutron-Ruault, Marie Christine (författare): University of Paris-Saclay,Institut Gustave Roussy

Carbonnel, Franck (författare): Bicêtre Hospital,University of Paris-Saclay,Institut Gustave Roussy

Cervenka, Iris (författare): Institut Gustave Roussy,University of Paris-Saclay

Boeing, Heiner (författare): German Institute of Human Nutrition

Kaaks, Rudolf (författare): German Cancer Research Centre

Kühn, Tilman (författare): German Cancer Research Centre

Trichopoulou, Antonia (författare): Hellenic Health Foundation, Athens

Martimianaki, Georgia (författare): Hellenic Health Foundation, Athens

Karakatsani, Anna (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens,Attikon University Hospital

Pala, Valeria (författare): Istituto Nazionale dei Tumori

Palli, Domenico (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Mattiello, Amalia (författare): University of Naples Federico II

Tumino, Rosario (författare): Civic and M.P Arezzo Hospital

Sacerdote, Carlotta (författare): Citta' della Salute e della Scienza Hospital-University of Turin

Skeie, Guri (författare): UiT The Arctic University of Norway, Tromsø

Rylander, Charlotta (författare): UiT The Arctic University of Norway, Tromsø

Chirlaque López, María Dolores (författare): University of Murcia,Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)

Sánchez, Maria Jose (författare): Hospital Clínico Universitario San Cecilio,CIBER Epidemiology and Public Health (CIBERESP),University of Granada

Ardanaz, Eva (författare): Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Regnér, Sara (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital

Stocks, Tanja (författare): Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments

Bueno-de-Mesquita, Bas (författare): University of Malaya,National Institute for Public Health and the Environment (RIVM),Imperial College London,University Medical Center Utrecht

Vermeulen, Roel C.H. (författare): Utrecht University,University Medical Center Utrecht

Aune, Dagfinn (författare): Imperial College London,Bjørknes University College,Oslo university hospital

Tong, Tammy Y.N. (författare): University of Oxford

Kliemann, Nathalie (författare): International Agency for Research on Cancer, World Health Organization

Murphy, Neil (författare): International Agency for Research on Cancer, World Health Organization

Chadeau-Hyam, Marc (författare): Imperial College London

Gunter, Marc J. (författare): International Agency for Research on Cancer, World Health Organization

Cross, Amanda J. (författare): Imperial College London

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2019-05-21
2020
Engelska 14 s.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:4, s. 929-942

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

cancer
esophageal
gastric
hormones
obesity
reproductive

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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Av lärosätet: Lunds universitet; Karolinska Institutet

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