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Molecular character...
Molecular characteristics of early-onset colorectal cancer according to detailed anatomical locations : comparison with later-onset cases
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- Ugai, Tomotaka (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Haruki, Koichiro (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Cao, Yin (författare)
- Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, MO, St Louis, United States; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
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- Qu, Conghui (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Chan, Andrew T. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Campbell, Peter T. (författare)
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
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- Akimoto, Naohiko (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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- Berndt, Sonja (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Buchanan, Daniel D. (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
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- Fujiyoshi, Kenji (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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- Gallinger, Steven J. (författare)
- Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Hidaka, Akihisa (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
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- Milne, Roger L. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
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- Moreno, Victor (författare)
- Oncology Data Analytics Program, Catalan Institute of Oncology (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Ciber de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Colorectal Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
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- Nishihara, Reiko (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Pai, Rish K. (författare)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Sakoda, Lori C. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Sun, Wei (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Amitay, Efrat L. (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Alwers, Elizabeth (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Thibodeau, Stephen N. (författare)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Toland, Amanda E. (författare)
- Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, OH, Columbus, United States
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Woods, Michael O. (författare)
- Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
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- Zaidi, Syed H. (författare)
- Ontario Institute for Cancer Research, ON, Toronto, Canada
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- Potter, John D. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Giannakis, Marios (författare)
- Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States; Broad Institute of Mit and Harvard, MA, Cambridge, United States
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- Song, Mingyang (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Nowak, Jonathan A. (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, MA, Boston, United States
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- Phipps, Amanda I. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Ogino, Shuji (författare)
- Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH. Chan School of Public Health, MA, Boston, United States Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States (creator_code:org_t)
- 2022-12-30
- 2023
- Engelska.
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Ingår i: American Journal of Gastroenterology. - : Wolters Kluwer. - 0002-9270 .- 1572-0241. ; 118:4, s. 712-726
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- INTRODUCTION:Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal length, the prevalence of certain tumor molecular characteristics gradually changes along colorectal subsites. Understanding how colorectal tumor molecular features differ by age and tumor location is important in personalized patient management.METHODS:Using 14,004 cases with colorectal cancer including 3,089 early-onset cases, we examined microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF mutations in carcinomas of the cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum and compared early-onset cases with later-onset cases.RESULTS:The proportions of MSI-high, CIMP-high, and BRAF-mutated early-onset tumors were lowest in the rectum (8.8%, 3.4%, and 3.5%, respectively) and highest in the ascending colon (46% MSI-high; 15% CIMP-high) or transverse colon (8.6% BRAF-mutated) (all Ptrend<0.001 across the rectum to ascending colon). Compared with later-onset tumors, early-onset tumors showed a higher prevalence of MSI-high status and a lower prevalence of CIMP-high status and BRAF mutations in most subsites. KRAS mutation prevalence was higher in the cecum compared with that in the other subsites in both early-onset and later-onset tumors (P < 0.001). Notably, later-onset MSI-high tumors showed a continuous decrease in KRAS mutation prevalence from the rectum (36%) to ascending colon (9%; Ptrend<0.001), followed by an increase in the cecum (14%), while early-onset MSI-high cancers showed no such trend.DISCUSSION:Our findings support biogeographical and pathogenic heterogeneity of colorectal carcinomas in different colorectal subsites and age groups.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- colorectal continuum
- colorectal neoplasm
- epigenetics
- mismatch repair
- molecular pathological epidemiology
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Ugai, Tomotaka
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Haruki, Koichiro
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Harrison, Tabith ...
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Cao, Yin
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Qu, Conghui
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Chan, Andrew T.
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visa fler...
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Campbell, Peter ...
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Akimoto, Naohiko
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Berndt, Sonja
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Brenner, Hermann
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Buchanan, Daniel ...
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Chang-Claude, Je ...
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Fujiyoshi, Kenji
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Gallinger, Steve ...
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Gunter, Marc J.
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Hidaka, Akihisa
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Hoffmeister, Mic ...
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Hsu, Li
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Jenkins, Mark A.
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Milne, Roger L.
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Moreno, Victor
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Newcomb, Polly A ...
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Nishihara, Reiko
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Pai, Rish K.
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Sakoda, Lori C.
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Slattery, Martha ...
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Sun, Wei
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Amitay, Efrat L.
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Alwers, Elizabet ...
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Thibodeau, Steph ...
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Toland, Amanda E ...
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van Guelpen, Bet ...
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Woods, Michael O ...
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Zaidi, Syed H.
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Potter, John D.
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Giannakis, Mario ...
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Song, Mingyang
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Nowak, Jonathan ...
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Phipps, Amanda I ...
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Peters, Ulrike
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Ogino, Shuji
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