Sökning: WFRF:(Bäckström David) >
Reliability and val...
Reliability and validity of visual analysis of [18F]FE-PE2I PET/CT in early Parkinsonian disease
-
- af Bjerkén, Sara (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Neurovetenskaper
-
- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
-
- Larsson, Anne (författare)
- Umeå universitet,Diagnostisk radiologi
-
visa fler...
-
- Flygare, Carolina (författare)
- Umeå universitet,Diagnostisk radiologi
-
- Remes, Jussi (författare)
- Umeå universitet,Diagnostisk radiologi
-
- Strandberg, Sara, 1976- (författare)
- Umeå universitet,Diagnostisk radiologi
-
- Eriksson, Linda (författare)
- Umeå universitet,Neurovetenskaper
-
- Bäckström, David C., M.D. 1978- (författare)
- Umeå universitet,Neurovetenskaper
-
- Jakobson Mo, Susanna, Medicine Doktor, 1968- (författare)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
-
visa färre...
-
(creator_code:org_t)
- 2023-03-03
- 2023
- Engelska.
-
Ingår i: Nuclear medicine communications. - : Wolters Kluwer. - 0143-3636 .- 1473-5628. ; 44:5, s. 397-406
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: [18F]FE-PE2I (FE-PE2I) is a new radiotracer for dopamine transporter (DAT) imaging with PET. The aim of this study was to evaluate the visual interpretation of FE-PE2I images for the diagnosis of idiopathic Parkinsonian syndrome (IPS). The inter-rater variability, sensitivity, specificity, and diagnostic accuracy for visual interpretation of striatal FE-PE2I compared to [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) was evaluated.Methods: Thirty patients with newly onset parkinsonism and 32 healthy controls with both an FE-PE2I and FP-CIT were included in the study. Four patients had normal DAT imaging, of which three did not fulfil the IPS criteria at the clinical reassessment after 2 years. Six raters evaluated the DAT images blinded to the clinical diagnosis, interpreting the image as being ‘normal’ or ‘pathological’, and assessed the degree of DAT-reduction in the caudate and putamen. The inter-rater agreement was assessed with intra-class correlation and Cronbach’s α. For calculation of sensitivity and specificity, DAT images were defined as correctly classified if categorized as normal or pathological by ≥4/6 raters.Results: The overall agreement in visual evaluation of the FE-PE2I- and FP-CIT images was high for the IPS patients (α = 0.960 and 0.898, respectively), but lower in healthy controls (FE-PE2I: α = 0.693, FP-CIT: α = 0.657). Visual interpretation gave high sensitivity (both 0.96) but lower specificity (FE-PE2I: 0.86, FP-CIT: 0.63) with an accuracy of 90% for FE-PE2I and 77% for FP-CIT.Conclusion: Visual evaluation of FE-PE2I PET imaging demonstrates high reliability and diagnostic accuracy for IPS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- [18F]FE-PE2I PET/computed tomography
- diagnostic accuracy
- early disease
- Parkinson’s disease
- PET
- Radiology
- radiologi
- neurologi
- Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
af Bjerkén, Sara
-
Axelsson, Jan, 1 ...
-
Larsson, Anne
-
Flygare, Carolin ...
-
Remes, Jussi
-
Strandberg, Sara ...
-
visa fler...
-
Eriksson, Linda
-
Bäckström, David ...
-
Jakobson Mo, Sus ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Radiologi och bi ...
- Artiklar i publikationen
-
Nuclear medicine ...
- Av lärosätet
-
Umeå universitet