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Cellular states are...
Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma
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- Puram, Sidharth V. (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
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- Mints, Michael (author)
- Karolinska Institutet,Umeå universitet,Urologi och andrologi,Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel; Department of Oncology–Pathology, Karolinska Institute, Stockholm, Sweden
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- Pal, Ananya (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Qi, Zongtai (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Reeb, Ashley (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Gelev, Kyla (author)
- Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States
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- Barrett, Thomas F. (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Gerndt, Sophie (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Liu, Ping (author)
- Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States; Department of Radiation Oncology, Washington University School of Medicine, MO, St. Louis, United States
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- Parikh, Anuraag S. (author)
- Department of Otolaryngology–Head and Neck Surgery, Columbia University Irving Medical Center, NY, New York, United States
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- Ramadan, Salma (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Law, Travis (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Mroz, Edmund A. (author)
- Department of Otolaryngology–Head and Neck Surgery, Ohio State University, OH, Columbus, United States
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- Rocco, James W. (author)
- Department of Otolaryngology–Head and Neck Surgery, Ohio State University, OH, Columbus, United States
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- Adkins, Doug (author)
- Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
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- Thorstad, Wade L. (author)
- Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Radiation Oncology, Washington University School of Medicine, MO, St. Louis, United States
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- Gay, Hiram A. (author)
- Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Radiation Oncology, Washington University School of Medicine, MO, St. Louis, United States
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- Ding, Li (author)
- Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States; McDonnell Genome Institute, Washington University in St. Louis, MO, St. Louis, United States
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- Paniello, Randal C. (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
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- Pipkorn, Patrik (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
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- Jackson, Ryan S. (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
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- Wang, Xiaowei (author)
- Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, IL, Chicago, United States
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- Mazul, Angela (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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- Chernock, Rebecca (author)
- Department of Pathology and Immunology, Washington University School of Medicine, MO, St. Louis, United States
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- Zevallos, Jose P. (author)
- Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
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- Silva-Fisher, Jessica (author)
- Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States
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- Tirosh, Itay (author)
- Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St Louis, United States; Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States Urologi och andrologi (creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:4, s. 640-650
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive and HPV-negative oropharyngeal tumors, uncovering a high level of cellular diversity within and between tumors. First, we detect diverse chromosomal aberrations within individual tumors, suggesting genomic instability and enabling the identification of malignant cells even at pathologically negative margins. Second, we uncover diversity with respect to HNSCC subtypes and other cellular states such as the cell cycle, senescence and epithelial-mesenchymal transitions. Third, we find heterogeneity in viral gene expression within HPV-positive tumors. HPV expression is lost or repressed in a subset of cells, which are associated with a decrease in HPV-associated cell cycle phenotypes, decreased response to treatment, increased invasion and poor prognosis. These findings suggest that HPV expression diversity must be considered during diagnosis and treatment of HPV-positive tumors, with important prognostic ramifications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Puram, Sidharth ...
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Mints, Michael
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Pal, Ananya
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Qi, Zongtai
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Reeb, Ashley
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Gelev, Kyla
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show more...
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Barrett, Thomas ...
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Gerndt, Sophie
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Liu, Ping
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Parikh, Anuraag ...
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Ramadan, Salma
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Law, Travis
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Mroz, Edmund A.
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Rocco, James W.
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Adkins, Doug
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Thorstad, Wade L ...
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Gay, Hiram A.
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Ding, Li
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Paniello, Randal ...
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Pipkorn, Patrik
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Jackson, Ryan S.
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Wang, Xiaowei
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Mazul, Angela
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Chernock, Rebecc ...
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Zevallos, Jose P ...
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Silva-Fisher, Je ...
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Tirosh, Itay
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University
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Karolinska Institutet