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Cohort profile: SUPER-Finland - the Finnish study for hereditary mechanisms of psychotic disorders

Lähteenvuo, Markku (författare)
Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Ahola-Olli, Ari (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States
Suokas, Kimmo (författare)
Faculty of Social Sciences, Tampere University, Tampere, Finland
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Holm, Minna (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Misiewicz, Zuzanna (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Jukuri, Tuomas (författare)
Department of Psychiatry, Oulu University Hospital, Oulu, Finland
Männynsalo, Teemu (författare)
Psychiatric and Substance Abuse Services, City of Helsinki, Helsinki, Finland
Wegelius, Asko (författare)
Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland; Department of Mental Health and Substance Abuse Services, Finnish Institute for Health and Welfare, Helsinki, Finland
Haaki, Willehard (författare)
Department of Psychiatry, University of Turku, Turku, Finland; Department of Psychiatry, TYKS Turku University Hospital, Turku, Finland
Kajanne, Risto (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Kyttälä, Aija (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Tuulio-Henriksson, Annamari (författare)
Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
Lahdensuo, Kaisla (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Häkkinen, Katja (författare)
Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland
Hietala, Jarmo (författare)
Department of Psychiatry, University of Turku, Turku, Finland; Department of Psychiatry, TYKS Turku University Hospital, Turku, Finland
Paunio, Tiina (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Niemi-Pynttäri, Jussi (författare)
Psychiatric and Substance Abuse Services, City of Helsinki, Helsinki, Finland
Kieseppä, Tuula (författare)
Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Veijola, Juha (författare)
Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Oulu, Finland; Medical Research Centre Oulu, University Hospital of Oulu and University of Oulu, Oulu, Finland
Lönnqvist, Jouko (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Isometsä, Erkki (författare)
Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Kampman, Olli (författare)
Umeå universitet,Psykiatri,Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, Pirkanmaa Wellbeing Services County, Tampere, Finland; Department of Clinical Medicine (Psychiatry), Faculty of Medicine, University of Turku, Turku, Finland; Department of Psychiatry, Wellbeing Services County of Ostrobothnia, Vaasa, Finland
Tiihonen, Jari (författare)
Karolinska Institutet
Hyman, Steven (författare)
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Department of Stem Cell and Regenerative Biology, Harvard University, MA, Cambridge, United States
Neale, Benjamin (författare)
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States
Daly, Mark (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Suvisaari, Jaana (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Palotie, Aarno (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States
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 (creator_code:org_t)
BMJ Publishing Group Ltd, 2023
2023
Engelska.
Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:4
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PURPOSE: SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to include Asian, Latin American and African populations in addition to known population isolates, such as Finland.PARTICIPANTS: 10 474 individuals aged 18 years or older were recruited throughout the country. The subjects have been genotyped with a genome-wide genotyping chip and exome sequenced. A subset of 897 individuals selected from known population sub-isolates were selected for whole-genome sequencing. Recruitment was done between November 2015 and December 2018.FINDINGS TO DATE: 5757 (55.2%) had a diagnosis of schizophrenia, 944 (9.1%) schizoaffective disorder, 1612 (15.5%) type I or type II bipolar disorder, 532 (5.1 %) psychotic depression, 1047 (10.0%) other psychosis and for 530 (5.1%) self-reported psychosis at recruitment could not be confirmed from register data. Mean duration of schizophrenia was 22.0 years at the time of the recruitment. By the end of the year 2018, 204 of the recruited individuals had died. The most common cause of death was cardiovascular disease (n=61) followed by neoplasms (n=40). Ten subjects had psychiatric morbidity as the primary cause of death.FUTURE PLANS: Compare the effects of common variants, rare variants and copy number variations (CNVs) on severity of psychotic illness. In addition, we aim to track longitudinal course of illness based on nation-wide register data to estimate how phenotypic and genetic differences alter it.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Depression & mood disorders
PSYCHIATRY
Schizophrenia & psychotic disorders

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