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Stratification of a...
Stratification of asthma by lipidomic profiling of induced sputum supernatant
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- Brandsma, Joost (författare)
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom
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- Schofield, James P.R. (författare)
- National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom; Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, United Kingdom
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- Yang, Xian (författare)
- Data Science Institute, Imperial College, London, United Kingdom
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- Strazzeri, Fabio (författare)
- Mathematical Sciences, University of Southampton, Southampton, United Kingdom
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- Barber, Clair (författare)
- National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom
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- Goss, Victoria M. (författare)
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom
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- Koster, Grielof (författare)
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom
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- Bakke, Per S. (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway
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- Caruso, Massimo (författare)
- Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
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- Chanez, Pascal (författare)
- Department of Respiratory Diseases, Aix-Marseille University, Marseille, France
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- Dahlén, Sven-Erik (författare)
- Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
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- Fowler, Stephen J. (författare)
- Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, United Kingdom; Manchester Academic Health Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
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- Horváth, Ildikó (författare)
- Department of Pulmonology, Semmelweis University, Budapest, Hungary
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- Krug, Norbert (författare)
- Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
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- Montuschi, Paolo (författare)
- Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy; National Heart and Lung Institute, Imperial College, London, United Kingdom
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- Sanak, Marek (författare)
- Department of Medicine, Jagiellonian University, Krakow, Poland
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- Sandström, Thomas, 1957- (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Shaw, Dominick E. (författare)
- National Institute for Health Research Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom
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- Chung, Kian Fan (författare)
- National Heart and Lung Institute, Imperial College, London, United Kingdom
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- Singer, Florian (författare)
- Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Paediatrics and Adolescent Medicine, Division of Paediatric Pulmonology and Allergology, Medical University of Graz, Graz, Austria
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- Fleming, Louise J. (författare)
- National Heart and Lung Institute, Imperial College, London, United Kingdom
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- Adcock, Ian M. (författare)
- National Heart and Lung Institute, Imperial College, London, United Kingdom
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- Pandis, Ioannis (författare)
- Data Science Institute, Imperial College, London, United Kingdom
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- Bansal, Aruna T. (författare)
- Acclarogen Ltd, St John's Innovation Centre, Cambridge, United Kingdom
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- Corfield, Julie (författare)
- Areteva Ltd, Nottingham, United Kingdom
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- Sousa, Ana R. (författare)
- Respiratory Therapy Unit, GlaxoSmithKline, London, United Kingdom
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- Sterk, Peter J. (författare)
- Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
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- Sánchez-García, Rubén J. (författare)
- Mathematical Sciences, University of Southampton, Southampton, United Kingdom
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- Skipp, Paul J. (författare)
- Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, United Kingdom
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- Postle, Anthony D. (författare)
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Djukanović, Ratko (författare)
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 152:1, s. 117-125
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Asthma is a chronic respiratory disease with significant heterogeneity in its clinical presentation and pathobiology. There is need for improved understanding of respiratory lipid metabolism in asthma patients and its relation to observable clinical features.Objective: We performed a comprehensive, prospective, cross-sectional analysis of the lipid composition of induced sputum supernatant obtained from asthma patients with a range of disease severities, as well as from healthy controls.Methods: Induced sputum supernatant was collected from 211 adults with asthma and 41 healthy individuals enrolled onto the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes) study. Sputum lipidomes were characterized by semiquantitative shotgun mass spectrometry and clustered using topologic data analysis to identify lipid phenotypes.Results: Shotgun lipidomics of induced sputum supernatant revealed a spectrum of 9 molecular phenotypes, highlighting not just significant differences between the sputum lipidomes of asthma patients and healthy controls, but also within the asthma patient population. Matching clinical, pathobiologic, proteomic, and transcriptomic data helped inform the underlying disease processes. Sputum lipid phenotypes with higher levels of nonendogenous, cell-derived lipids were associated with significantly worse asthma severity, worse lung function, and elevated granulocyte counts.Conclusion: We propose a novel mechanism of increased lipid loading in the epithelial lining fluid of asthma patients resulting from the secretion of extracellular vesicles by granulocytic inflammatory cells, which could reduce the ability of pulmonary surfactant to lower surface tension in asthmatic small airways, as well as compromise its role as an immune regulator.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asthma
- epithelial lining fluid
- extracellular vesicles
- granulocytic inflammation
- induced sputum
- lipidomics
- molecular phenotyping
- pulmonary surfactant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Brandsma, Joost
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Schofield, James ...
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Yang, Xian
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Strazzeri, Fabio
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Barber, Clair
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Goss, Victoria M ...
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visa fler...
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Koster, Grielof
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Bakke, Per S.
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Caruso, Massimo
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Chanez, Pascal
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Dahlén, Sven-Eri ...
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Fowler, Stephen ...
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Horváth, Ildikó
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Krug, Norbert
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Montuschi, Paolo
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Sanak, Marek
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Sandström, Thoma ...
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Shaw, Dominick E ...
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Chung, Kian Fan
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Singer, Florian
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Fleming, Louise ...
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Adcock, Ian M.
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Pandis, Ioannis
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Bansal, Aruna T.
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Corfield, Julie
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Sousa, Ana R.
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Sterk, Peter J.
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Sánchez-García, ...
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Skipp, Paul J.
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Postle, Anthony ...
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Djukanović, Ratk ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Journal of Aller ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet