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Anti-CD74 IgA autoa...
Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis : a longitudinal Swedish study
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- Do, Lan (författare)
- Umeå University,Umeå universitet,Reumatologi
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- Granåsen, Gabriel, 1980- (författare)
- Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Hellman, Urban, 1966- (författare)
- Umeå University,Umeå universitet,Reumatologi
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- Lejon, Kristina, 1967- (författare)
- Umeå University,Umeå universitet,Immunologi/immunkemi
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- Geijer, Mats (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Baraliakos, Xenofon (författare)
- Department of Biochemistry, Ruhr-Universität Bochum, Bochum, Germany
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- Witte, Torsten (författare)
- Department of Rheumatology and Clinical Immunology, Medical University Hannover, Hannover, Germany,Hannover Medical School
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- Forsblad-d'Elia, Helena (författare)
- Gothenburg University,Göteborgs universitet,Umeå University,Umeå universitet,Reumatologi,Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Rheumatology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2020-12-28
- 2021
- Engelska.
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Ingår i: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332 .- 1310-0505. ; 60:9, s. 4085-4093
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://academic.oup...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes.METHODS: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age- and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden.RESULTS: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed.CONCLUSION: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- IgA anti-CD74
- outcomes research
- radiographic axial spondyloarthritis ankylosing spondylitis
- IgA anti-CD74
- Outcomes research
- Radiographic axial spondyloarthritis ankylosing spondylitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Do, Lan
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Granåsen, Gabrie ...
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Hellman, Urban, ...
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Lejon, Kristina, ...
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Geijer, Mats
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Baraliakos, Xeno ...
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Witte, Torsten
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Forsblad-d'Elia, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Rheumatology
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Umeå universitet
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Lunds universitet
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