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Diabetes and heart failure associations in women and men : Results from the MORGAM consortium

Chadalavada, Sucharitha (författare)
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom
Reinikainen, Jaakko (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
Andersson, Jonas, 1977- (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Di Castelnuovo, Augusto (författare)
Mediterranea Cardiocentro, Naples, Italy
Iacoviello, Licia (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine—EPIMED, Department of Medicine and Surgery, University of Insubria, Varese, Italy
Jousilahti, Pekka (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
Kårhus, Line Lund (författare)
Center for Clinical Research and Prevention, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, Denmark
Linneberg, Allan (författare)
Center for Clinical Research and Prevention, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Söderberg, Stefan (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Tunstall-Pedoe, Hugh (författare)
Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom
Lekadir, Karim (författare)
Artificial Intelligence in Medicine Lab (BCN-AIM), Departament de Matemàtiques and Informàtica, Universitat de Barcelona, Barcelona, Spain
Aung, Nay (författare)
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom
Jensen, Magnus T. (författare)
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, Herlev, Denmark
Kuulasmaa, Kari (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
Niiranen, Teemu J. (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Department of Internal Medicine, University of Turku and Turku University Hospital, Turku, Finland
Petersen, Steffen E. (författare)
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Health Data Research UK, London, United Kingdom; National Institute for Health and Care Research, London, United Kingdom
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 (creator_code:org_t)
2023
2023
Engelska.
Ingår i: Frontiers in Cardiovascular Medicine. - 2297-055X. ; 10
Relaterad länk:
https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Diabetes and its cardiovascular complications are a growing concern worldwide. Recently, some studies have demonstrated that relative risk of heart failure (HF) is higher in women with type 1 diabetes (T1DM) than in men. This study aims to validate these findings in cohorts representing five countries across Europe.Methods: This study includes 88,559 (51.8% women) participants, 3,281 (46.3% women) of whom had diabetes at baseline. Survival analysis was performed with the outcomes of interest being death and HF with a follow-up time of 12 years. Sub-group analysis according to sex and type of diabetes was also performed for the HF outcome.Results: 6,460 deaths were recorded, of which 567 were amongst those with diabetes. Additionally, HF was diagnosed in 2,772 individuals (446 with diabetes). A multivariable Cox proportional hazard analysis showed that there was an increased risk of death and HF (hazard ratio (HR) of 1.73 [1.58–1.89] and 2.12 [1.91–2.36], respectively) when comparing those with diabetes and those without. The HR for HF was 6.72 [2.75–16.41] for women with T1DM vs. 5.80 [2.72–12.37] for men with T1DM, but the interaction term for sex differences was insignificant (p for interaction 0.45). There was no significant difference in the relative risk of HF between men and women when both types of diabetes were combined (HR 2.22 [1.93–2.54] vs. 1.99 [1.67–2.38] respectively, p for interaction 0.80).Conclusion: Diabetes is associated with increased risks of death and heart failure, and there was no difference in relative risk according to sex.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

diabetes
epidemiology
heart failure
MORGAM
sex differences

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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