Search: id:"swepub:oai:DiVA.org:umu-209177" >
Single nucleotide p...
-
Oliva, DelmyDepartment of Oncology, Ryhov County Hospital, Jönköping, Sweden; delmy.oliva@rjl.se,Ryhov Cty Hosp, Sweden
(author)
Single nucleotide polymorphism directed antiemetic treatment in women with breast cancer treated with neo- or adjuvant chemotherapy : a randomised multicentre phase II study. (EudraCT: 2015–000658-39)
- Article/chapterEnglish2023
Publisher, publication year, extent ...
-
International Institute of Anticancer Research,2023
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-209177
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-209177URI
-
https://doi.org/10.21873/anticanres.16433DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-60836URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196093URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding Agencies|Foundation for Clinical Cancer Research in Jonkoping and Futurum Academy for Health and Care, Region Jonkoping County; Medical Research Council of Southeast Sweden, FORSS
-
Background/aim: The role of single nucleotide polymorphisms (SNPs) in the frequency and intensity of chemotherapy-induced nausea and vomiting (CINV) in women with breast cancer (BC) is unclear. The primary purpose of this study was to compare/evaluate the effect of SNP-guided antiemetic treatment versus standard CINV treatment.Patients and methods: A randomised, factorial, phase II multicentre study design was used. Women planned for neoadjuvant or adjuvant chemotherapy with epirubicin, cyclophosphamide and fluorouracil (FEC /EC, with or without fluorouracil) for BC were randomised to SNP-guided antiemetic treatment (based on the results of SNP analyses) versus standard CINV treatment. Blood samples were taken before the treatment was initiated. Patient-reported data on CINV (during 10 days from onset of cancer treatment) and health-related quality of life (HRQoL), were collected before and after the first cancer treatment.Results: A total of 188 women were included. Overall, nausea was reported by 86% (n=129) of the patients during the ten-day period from the start of cancer treatment. The SNP genotype studied varied. In FAS-CD95, the genotypes AG and GG were overrepresented; in RB1-LPAR6, GG was overrepresented, and in CCL2, both AA and GG were overrepresented. We found no statistically significant difference in CINV between SNP-guided antiemetic treatment versus standard CINV treatment.Conclusion: SNP-guided antiemetic treatment could be as effective as standard treatment. SNP-guided antiemetic treatment of CINV is possibly useful in detecting patients with a higher or lower risk for CINV and thus may help in avoiding over-treatment with toxic components. CINV negatively affects the HRQL.Keywords: Breast cancer; chemotherapy-induced nausea and vomiting; single nucleotide polymorphism.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Andersson, Bengt-ÅkeJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Jonkoping Univ, Sweden(Swepub:hj)andben
(author)
-
Shamoun, LevarDepartment of Laboratory Medicine and Pathology, Region Jönköping County, Jönköping, Sweden,Reg Jonkoping Cty, Sweden
(author)
-
Lewin, NongnitLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)nonle33
(author)
-
Nilsson, Mats P.Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Reg Jonkoping Cty, Sweden(Swepub:liu)n/a
(author)
-
Schildt, Elsy-BrittDepartment of Oncology, Kalmar County Hospital, Kalmar, Sweden,Kalmar Cty Hosp, Sweden
(author)
-
Fust, LisaDepartment of Oncology, Kalmar County Hospital, Kalmar, Sweden,Kalmar Cty Hosp, Sweden
(author)
-
Åsenlund, UlrikaTrial Unit, Department of Oncology, Gävle County Hospital, Gävle, Sweden,Gavle Cty Hosp, Sweden
(author)
-
Sellerstam, GunillaTrial Unit, Department of Oncology, SöderHospital AB, Stockholm, Sweden
(author)
-
Elinder, EllinorTrial Unit, Department of Oncology, SöderHospital AB, Stockholm, Sweden
(author)
-
Sharp, Lena,PhDUmeå universitet,Institutionen för omvårdnad,Department of Nursing, Umeå University, Umeå, Sweden; Regional Cancer Centre Stockholm-Gotland, Stockholm, Sweden,Umea Univ, Sweden; Reg Canc Ctr Stockholm Gotland, Sweden(Swepub:umu)lesh0006
(author)
-
Lewin, FreddiJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden,Ryhov Cty Hosp, Sweden; Jonkoping Univ, Sweden
(author)
-
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden; delmy.oliva@rjl.seRyhov Cty Hosp, Sweden
(creator_code:org_t)
Related titles
-
In:Anticancer Research: International Institute of Anticancer Research43:6, s. 2671-26810250-70051791-7530
Internet link
Find in a library
To the university's database
- By the author/editor
-
Oliva, Delmy
-
Andersson, Bengt ...
-
Shamoun, Levar
-
Lewin, Nongnit
-
Nilsson, Mats P.
-
Schildt, Elsy-Br ...
-
show more...
-
Fust, Lisa
-
Åsenlund, Ulrika
-
Sellerstam, Guni ...
-
Elinder, Ellinor
-
Sharp, Lena, PhD
-
Lewin, Freddi
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nursing
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
- Articles in the publication
-
Anticancer Resea ...
- By the university
-
Umeå University
-
Jönköping University
-
Linköping University