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Measurable residual...
Measurable residual disease and fusion partner independently predict survival and relapse risk in childhood KMT2A-rearranged acute myeloid leukemia : a study by the international Berlin-Frankfurt-Münster study group
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- van Weelderen, Romy E. (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Pediatric Oncology, Emma Children's Hospital, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
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- Klein, Kim (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Pediatric Oncology, Emma Children's Hospital, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, Netherlands
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- Harrison, Christine J. (författare)
- Leukemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle-upon-Tyne, United Kingdom
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- Jiang, Yilin (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
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- Abrahamsson, Jonas (författare)
- Department of Pediatrics, Institute of Clinical Sciences, Salgrenska University Hospital, Gothenburg, Sweden
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- Arad-Cohen, Nira (författare)
- Pediatric Hemato-Oncology Department, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel
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- Bart-Delabesse, Emmanuelle (författare)
- IUC Toulouse-Oncopole, Laboratoire d'Hématologie secteur Génétique des Hémopathies, Toulouse, France
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- Buldini, Barbara (författare)
- Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, Padua University, Padua, Italy
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- De Moerloose, Barbara (författare)
- Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
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- Dworzak, Michael N. (författare)
- St. Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, St Anna Children's Cancer Research Institute, Vienna, Austria
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- Elitzur, Sarah (författare)
- Department of Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Tel Aviv, Israel
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- Fernández Navarro, José M (författare)
- Pediatric Oncohematology Unit, Hospital Universitari i Politècnic la Fe, Valencia, Spain
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- Gerbing, Robert B. (författare)
- Department of Statistics, Children's Oncology Group, CA, Monrovia, United States
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- Goemans, Bianca F. (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
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- de Groot-Kruseman, Hester A. (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; DCOG, Dutch Childhood Oncology Group, Utrecht, Netherlands
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- Guest, Erin (författare)
- Children's Mercy Kansas City, MO, Kansas City, United States
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- Ha, Shau-Yin (författare)
- Department of Pediatrics & Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong
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- Hasle, Henrik (författare)
- Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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- Kelaidi, Charikleia (författare)
- Department of Pediatric Hematology and Oncology, Aghia Sophia Children's Hospital, Athens, Greece
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- Lapillonne, Hélène (författare)
- Pediatric Hematology and Oncology Department, Hôpital Armand Trousseau, Paris, France
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- Leverger, Guy (författare)
- Pediatric Hematology and Oncology Department, Hôpital Armand Trousseau, Paris, France
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- Locatelli, Franco (författare)
- Department of Pediatric Hematology and Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy
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- Masetti, Riccardo (författare)
- Pediatric Oncology and Hematology, University of Bologna, Bologna, Italy
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- Miyamura, Takako (författare)
- Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
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- Norén-Nyström, Ulrika (författare)
- Umeå universitet,Pediatrik
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- Polychronopoulou, Sophia (författare)
- Department of Pediatric Hematology and Oncology, Aghia Sophia Children's Hospital, Athens, Greece
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- Rasche, Mareike (författare)
- Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
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- Rubnitz, Jeffrey E. (författare)
- Department of Oncology, St Jude Children's Research Hospital, TN, Memphis, United States
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- Stary, Jan (författare)
- Department of Pediatric Hematology and Oncology, University Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
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- Tierens, Anne (författare)
- Department of Pathobiology and Laboratory Medicine, Toronto General Hospital, University Health Network, ON, Toronto, Canada
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- Tomizawa, Daisuke (författare)
- Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan
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- Zwaan, C Michel (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
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- Kaspers, Gertjan J L (författare)
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Pediatric Oncology, Emma Children's Hospital, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
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(creator_code:org_t)
- American Society of Clinical Oncology (ASCO), 2023
- 2023
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 41:16, s. 2963-2974
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: A previous study by the International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) on childhood KMT2A-rearranged (KMT2A-r) AML demonstrated the prognostic value of the fusion partner. This I-BFM-SG study investigated the value of flow cytometry-based measurable residual disease (flow-MRD) and evaluated the benefit of allogeneic stem-cell transplantation (allo-SCT) in first complete remission (CR1) in this disease.Methods: A total of 1,130 children with KMT2A-r AML, diagnosed between January 2005 and December 2016, were assigned to high-risk (n = 402; 35.6%) or non-high-risk (n = 728; 64.4%) fusion partner-based groups. Flow-MRD levels at both end of induction 1 (EOI1) and 2 (EOI2) were available for 456 patients and were considered negative (<0.1%) or positive (≥0.1%). End points were 5-year event-free survival (EFS), cumulative incidence of relapse (CIR), and overall survival (OS).Results: The high-risk group had inferior EFS (30.3% high risk v 54.0% non-high risk; P < .0001), CIR (59.7% v 35.2%; P < .0001), and OS (49.2% v 70.5%; P < .0001). EOI2 MRD negativity was associated with superior EFS (n = 413; 47.6% MRD negativity v n = 43; 16.3% MRD positivity; P < .0001) and OS (n = 413; 66.0% v n = 43; 27.9%; P < .0001), and showed a trend toward lower CIR (n = 392; 46.1% v n = 26; 65.4%; P = .016). Similar results were obtained for patients with EOI2 MRD negativity within both risk groups, except that within the non-high-risk group, CIR was comparable with that of patients with EOI2 MRD positivity. Allo-SCT in CR1 only reduced CIR (hazard ratio, 0.5 [95% CI, 0.4 to 0.8]; P = .00096) within the high-risk group but did not improve OS. In multivariable analyses, EOI2 MRD positivity and high-risk group were independently associated with inferior EFS, CIR, and OS.Conclusion: EOI2 flow-MRD is an independent prognostic factor and should be included as risk stratification factor in childhood KMT2A-r AML. Treatment approaches other than allo-SCT in CR1 are needed to improve prognosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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van Weelderen, R ...
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Klein, Kim
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Harrison, Christ ...
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Jiang, Yilin
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Abrahamsson, Jon ...
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Arad-Cohen, Nira
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Bart-Delabesse, ...
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Buldini, Barbara
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De Moerloose, Ba ...
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Dworzak, Michael ...
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Elitzur, Sarah
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Fernández Navarr ...
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Gerbing, Robert ...
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Goemans, Bianca ...
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de Groot-Krusema ...
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Guest, Erin
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Ha, Shau-Yin
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Hasle, Henrik
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Kelaidi, Charikl ...
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Lapillonne, Hélè ...
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Leverger, Guy
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Locatelli, Franc ...
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Masetti, Riccard ...
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Miyamura, Takako
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Norén-Nyström, U ...
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Polychronopoulou ...
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Rasche, Mareike
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Rubnitz, Jeffrey ...
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Stary, Jan
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Tierens, Anne
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Tomizawa, Daisuk ...
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Zwaan, C Michel
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Kaspers, Gertjan ...
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