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Dissecting the gene...
Dissecting the genetic heterogeneity of gastric cancer
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- Hess, Timo (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
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- Maj, Carlo (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany; Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
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- Gehlen, Jan (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany
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- Borisov, Oleg (författare)
- Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
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- Haas, Stephan L. (författare)
- Karolinska Institutet
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- Gockel, Ines (författare)
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
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- Vieth, Michael (författare)
- Institute for Pathology, Friedrich-Alexander-University Erlangen-Nuernberg, Klinikum Bayreuth, Bayreuth, Germany
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- Piessen, Guillaume (författare)
- Department of Digestive and Oncological Surgery, Claude Huriez Hospital, CHU Lille, Lille, France
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- Alakus, Hakan (författare)
- Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
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- Vashist, Yogesh (författare)
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany; Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
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- Pereira, Carina (författare)
- Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO Porto), Porto, Portugal; Porto Comprehensive Cancer Center & RISE @ CI-IPO, University of Porto, Porto, Portugal
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- Knapp, Michael (författare)
- Medical Faculty, Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
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- Schüller, Vitalia (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany
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- Quaas, Alexander (författare)
- Medical Faculty, Institute of Pathology, University Hospital Cologne, University of Cologne, Germany
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- Grabsch, Heike I. (författare)
- Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands; Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
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- Trautmann, Jessica (författare)
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
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- Malecka-Wojciesko, Ewa (författare)
- Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland
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- Mokrowiecka, Anna (författare)
- Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland
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- Speller, Jan (författare)
- Medical Faculty, Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
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- Mayr, Andreas (författare)
- Medical Faculty, Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
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- Schröder, Julia (författare)
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
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- Hillmer, Axel M. (författare)
- Medical Faculty, Institute of Pathology, University Hospital Cologne, University of Cologne, Germany
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- Heider, Dominik (författare)
- Department of Mathematics and Computer Science, University of Marburg, Marburg, Germany
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- Lordick, Florian (författare)
- University Cancer Center Leipzig, Leipzig University Medical Center, Leipzig, Germany
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- Pérez-Aísa, Ángeles (författare)
- Department of Gastroenterology, Hospital Costa del Sol, Marbella, Spain
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- Campo, Rafael (författare)
- Department of Gastroenterology, Hospital Parc Tauli, Sabadell, Spain
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- Espinel, Jesús (författare)
- Department of Gastroenterology, Complejo Hospitalario, León, Spain
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- Geijo, Fernando (författare)
- Department of Gastroenterology, Hospital Clínico Universitario, Salamanca, Spain
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- Thomson, Concha (författare)
- Department of Gastroenterology, Hospital Obispo Polanco, Teruel, Spain
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- Bujanda, Luis (författare)
- CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Universidad del País Vasco (UPV/EHU), San Sebastián, Spain
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- Sopeña, Federico (författare)
- CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
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- Lanas, Ángel (författare)
- CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain
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- Pellisé, María (författare)
- CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Department of Gastroenterology, Hospital Clinic of Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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- Pauligk, Claudia (författare)
- Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany; Institut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
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- Goetze, Thorsten Oliver (författare)
- Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany; Institut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
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- Zelck, Carolin (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany
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- Reingruber, Julian (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany
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- Hassanin, Emadeldin (författare)
- Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
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- Elbe, Peter (författare)
- Department of Upper GI Diseases, Karolinska Institutet, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Stockholm, Sweden
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- Alsabeah, Sandra (författare)
- Department of Upper GI Diseases, Karolinska Institutet, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Stockholm, Sweden
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- Lindblad, Mats (författare)
- Division of Surgery, Department of Upper GI Diseases, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Nilsson, Magnus (författare)
- Karolinska Institutet
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- Kreuser, Nicole (författare)
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
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- Thieme, René (författare)
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
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- Tavano, Francesca (författare)
- Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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- Pastorino, Roberta (författare)
- Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
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- Arzani, Dario (författare)
- Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy
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- Persiani, Roberto (författare)
- Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
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- Jung, Jin-On (författare)
- Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
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- Nienhüser, Henrik (författare)
- Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
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- Ott, Katja (författare)
- Department of Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany
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- Schumann, Ralf R. (författare)
- Institute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
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- Kumpf, Oliver (författare)
- Department of Anaesthesiology and Operative Intensive Care Medicine, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
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- Burock, Susen (författare)
- Charité Comprehensive Cancer Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
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- Arndt, Volker (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Jakubowska, Anna (författare)
- Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Poland; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University in Szczecin, Poland
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- Ławniczak, Małgorzta (författare)
- Department of Gastroenterology, Pomeranian Medical University in Szczecin, Poland
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- Moreno, Victor (författare)
- Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Hospital Duran I Reynals, Barcelona, Spain; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Faculty of Medicine, Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
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- Martín, Vicente (författare)
- Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; The Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain; Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de Leon, Leon, Spain
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- Kogevinas, Manolis (författare)
- Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Campus Del Mar, Barcelona, Spain; IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain
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- Pollán, Marina (författare)
- Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
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- Dąbrowska, Justyna (författare)
- Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
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- Salas, Antonio (författare)
- Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain
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- Cussenot, Olivier (författare)
- CeRePP, Paris, France; GRC n°5 Predictive Onco-Urology, Tenon Hospital, Sorbonne University, Paris, France
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- Boland-Auge, Anne (författare)
- Centre National de Recherche en Génomique Humaine, CEA, University Paris-Saclay, Evry, France
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- Daian, Delphine (författare)
- Centre National de Recherche en Génomique Humaine, CEA, University Paris-Saclay, Evry, France
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- Deleuze, Jean-Francois (författare)
- Centre National de Recherche en Génomique Humaine, CEA, University Paris-Saclay, Evry, France
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- Salvi, Erika (författare)
- Neuroalgology Unit Fondazione IRCCS, Instituto Neurologico 'Carlo Besta' Milan, Milan, Italy
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- Teder-Laving, Maris (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Tomasello, Gianluca (författare)
- Medical Oncology Unit, ASST of Cremona, Cremona, Italy; Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
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- Ratti, Margherita (författare)
- Medical Oncology Unit, ASST of Cremona, Cremona, Italy
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- Senti, Chiara (författare)
- Medical Oncology Unit, ASST of Cremona, Cremona, Italy; Department of Medical Oncology, Institut Jules Bordet - Université Libre de Bruxelles (ULB), Brussels, Belgium
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- De Re, Valli (författare)
- Unit of Immunopathologia e Biomarcatori Oncologici/Bio-proteomics Facility, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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- Steffan, Agostino (författare)
- Unit of Immunopathologia e Biomarcatori Oncologici, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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- Hölscher, Arnulf H. (författare)
- Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
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- Messerle, Katharina (författare)
- Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
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- Bruns, Christiane Josephine (författare)
- Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
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- Sīviņš, Armands (författare)
- Institute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia
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- Bogdanova, Inga (författare)
- Institute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia
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- Skieceviciene, Jurgita (författare)
- Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
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- Arstikyte, Justina (författare)
- Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
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- Moehler, Markus (författare)
- Department of Medicine I, University Medical Center of Johannes Gutenberg University Mainz, Mainz, Germany
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- Lang, Hauke (författare)
- Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany
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- Grimminger, Peter P. (författare)
- Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany
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- Kruschewski, Martin (författare)
- Department of General and Visceral Surgery, Klinikum Frankfurt (Oder), Germany
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- Vassos, Nikolaos (författare)
- Division of Surgical Oncology and Thoracic Surgery, Department of Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
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- Schildberg, Claus (författare)
- Department of General Surgery, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, Brandenburg, Germany
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- Lingohr, Philipp (författare)
- Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, Bonn, Germany
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- Ridwelski, Karsten (författare)
- Department of General and Visceral Surgery, Klinikum Magdeburg GmbH, Magdeburg, Germany
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- Lippert, Hans (författare)
- Institute of Quality Assurance in Operative Medicine, Otto-von-Guericke University Hospital, Magdeburg, Germany
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- Fricker, Nadine (författare)
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
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- Krawitz, Peter (författare)
- Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
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- Hoffmann, Per (författare)
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
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- Nöthen, Markus M. (författare)
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
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- Veits, Lothar (författare)
- Institute for Pathology, Friedrich-Alexander-University Erlangen-Nuernberg, Klinikum Bayreuth, Bayreuth, Germany
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- Izbicki, Jakob R. (författare)
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany
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- Mostowska, Adrianna (författare)
- Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
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- Martinón-Torres, Federico (författare)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain; Department of Pediatrics, Translational Pediatrics and Infectious Diseases Section, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Spain; Genetics, Vaccines, Infectious Diseases and Pediatrics Research Group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
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- Cusi, Daniele (författare)
- Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy; Bio4Dreams-Business, Nursery for Life Sciences, Milan, Italy
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Cancel-Tassin, Geraldine (författare)
- CeRePP, Paris, France; GRC n°5 Predictive Onco-Urology, Tenon Hospital, Sorbonne University, Paris, France
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- Höblinger, Aksana (författare)
- Department of Internal Medicine I, Community Hospital Mittelrhein, Koblenz, Germany
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- Rodermann, Ernst (författare)
- Association of Medical Practices in Hematology and Internal Oncology, Troisdorf, Germany
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- Ludwig, Monika (författare)
- Association for Oncological Studies (Gefos), Dortmund, Germany
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- Keller, Gisela (författare)
- Institute of Pathology, Technical University of Munich, Munich, Germany
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- Metspalu, Andres (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Heller, Joerg (författare)
- Department of Gastroenterology, Marienhaus Hospital Ahrweiler, Ahrweiler, Germany
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- Neef, Markus (författare)
- Department of Gastroenterology, Helios Hospital Siegburg, Siegburg, Germany
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- Schepke, Michael (författare)
- Department of Gastroenterology, Helios Hospital Siegburg, Siegburg, Germany
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- Dumoulin, Franz Ludwig (författare)
- Department of Gastroenterology, St. Elisabeth Hospital Bonn, Bonn, Germany
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- Hamann, Lutz (författare)
- Institute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
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- Cannizzaro, Renato (författare)
- Unit of Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
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- Ghidini, Michele (författare)
- Medical Oncology Unit, ASST of Cremona, Cremona, Italy; Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
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- Plaßmann, Dominik (författare)
- Gastroenterological Centre, Dr. Plaßmann, Bonn, Germany
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- Geppert, Michael (författare)
- Gastroenterological Centre, Dr. Geppert, Bayreuth, Germany
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- Malfertheiner, Peter (författare)
- Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany; Department of Internal Medicine II, Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
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- Gehlen, Olivier (författare)
- Department of Surgical Oncology, Centre Hospitalier Lyon-sud, Lyon, France
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- Skoczylas, Tomasz (författare)
- 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland
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- Majewski, Marek (författare)
- 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland
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- Lubiński, Jan (författare)
- Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Poland
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- Palmieri, Orazio (författare)
- Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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- Boccia, Stefania (författare)
- Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy
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- Latiano, Anna (författare)
- Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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- Aragones, Nuria (författare)
- Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
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- Schmidt, Thomas (författare)
- Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
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- Dinis-Ribeiro, Mário (författare)
- Porto Comprehensive Cancer Center & RISE @ CI-IPO, University of Porto, Porto, Portugal; Gastroenterology Department, Portuguese Institute of Oncology of Porto, Porto, Portugal
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- Medeiros, Rui (författare)
- Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO Porto), Porto, Portugal; Research Department of the Portuguese League Against Cancer-North (LPCC-NRNorte), Porto, Portugal
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- Al-Batran, Salah-Eddin (författare)
- Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany; Institut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
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- Leja, Mārcis (författare)
- Institute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia; Digestive Diseases Centre GASTRO, Riga, Latvia
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- Kupcinskas, Juozas (författare)
- Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
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- García-González, María A. (författare)
- CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain; Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain
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- Venerito, Marino (författare)
- Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany
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- Schumacher, Johannes (författare)
- Institute of Human Genetics, University of Marburg, Marburg, Germany
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO.Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level.Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Gastric cancer
- Genome-wide association study (GWAS)
- Oesophageal adenocarcinoma
- Transcriptome-wide association study (TWAS)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hess, Timo
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