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Human genetic struc...
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Alves, IsabelNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.;Univ Strasbourg, CNRS, GMGM, Strasbourg, France.
(author)
Human genetic structure in Northwest France provides new insights into West European historical demography
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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Springer Nature,2024
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-537288
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-537288URI
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https://doi.org/10.1038/s41467-024-51087-1DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The demographical history of France remains largely understudied despite its central role toward understanding modern population structure across Western Europe. Here, by exploring publicly available Europe-wide genotype datasets together with the genomes of 3234 present-day and six newly sequenced medieval individuals from Northern France, we found extensive fine-scale population structure across Brittany and the downstream Loire basin and increased population differentiation between the northern and southern sides of the river Loire, associated with higher proportions of steppe vs. Neolithic-related ancestry. We also found increased allele sharing between individuals from Western Brittany and those associated with the Bell Beaker complex. Our results emphasise the need for investigating local populations to better understand the distribution of rare (putatively deleterious) variants across space and the importance of common genetic legacy in understanding the sharing of disease-related alleles between Brittany and people from western Britain and Ireland.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Giemza, JoannaNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
(author)
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Blum, Michael G. B.Univ Grenoble Alpes, TIMC IMAG, UMR 5525 CNRS, Grenoble, France.
(author)
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Bernhardsson, CarolinaUppsala universitet,Människans evolution(Swepub:uu)carbe305
(author)
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Chatel, StephanieNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Karakachoff, MatildeNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.;Nantes Univ, CHU Nantes, Pole Hosp Univ 11 Sante Publ, Clin Donnees,INSERMC 1413, Nantes, France.
(author)
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Saint Pierre, AudeUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.
(author)
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Herzig, Anthony F.Univ Brest, Inserm, EFS, UMR 107,GGB, Brest, France.
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Olaso, RobertUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
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Monteil, MartialNantes Univ, Minist Culture, CNRS, CReAAH,LARA, Nantes, France.
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Gallien, VeroniqueINRAP Inst Natl Rech Archeol Prevent, Paris, France.;CEPAM UMR7264 Culture & Environm, Prehist, Antiquite, Nice, France.
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Cabot, ElodieINRAP Inst Natl Rech Archeol Prevent, Paris, France.;Fac Med Site Nord, Anthropol Bioculturelle Droit Eth & Sante, Marseille, France.
(author)
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Svensson, Emma,1979-Uppsala universitet,Människans evolution(Swepub:uu)emsve020
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Bacq, DelphineUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
(author)
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Baron, EstelleNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Berthelier, CharlotteNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Besse, CelineUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
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Blanche, HeleneFdn Jean Dausset, CEPH, Paris, France.
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Bocher, OzvanUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.
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Boland, AnneUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
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Bonnaud, StephanieNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Charpentier, EricNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Dandine-Roulland, ClaireUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
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Ferec, ClaudeUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.;CHRU Brest, Brest, France.
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Fruchet, ChristineNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Lecointe, SimonNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Le Floch, EdithUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
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Ludwig, Thomas E.Univ Brest, Inserm, EFS, UMR 107,GGB, Brest, France.;CHRU Brest, Brest, France.
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Marenne, GaelleUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.
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Meyer, VincentUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.
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Quellery, ElisabethNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Racimo, FernandoUniv Copenhagen, Globe Inst, Sect Mol Ecol & Evolut, Copenhagen, Denmark.
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Rouault, KarenUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.;CHRU Brest, Brest, France.
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Sandron, FlorianUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.
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Schott, Jean-JacquesNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
(author)
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Velo-Suarez, LourdesUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.
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Violleau, JadeNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Willerslev, EskeUniv Copenhagen, GLOBE Inst, Lundbeck GeoGenet Ctr, Copenhagen, Denmark.;Univ Cambridge, Dept Zool, Cambridge, England.
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Coativy, YvesUniv Bretagne Occidentale, Ctr Rech Bretonne & Celt, UR 4451, Brest, France.
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Jezequel, MaelUniv Bretagne Occidentale, Ctr Rech Bretonne & Celt, UR 4451, Brest, France.
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Le Bris, DanielUniv Bretagne Occidentale, Ctr Rech Bretonne & Celt, UR 4451, Brest, France.
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Nicolas, ClementUniv Paris 1 Pantheon Sorbonne, Ctr Malher, CNRS UMR Trajectoires 8215, 9 Rue Malher, Paris, France.
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Pailler, YvanUniv Brest, Univ Nantes, Univ Rennes 2, Inst Univ Europeen Mer,CPJ ArMeRIE UBO,UMR 6554 LE, Plouzane, France.
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Goldberg, MarcelParis Saclay Univ, Univ Paris Cite, Populat Based Cohorts Unit, INSERM,UVSQ, Paris, France.
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Zins, MarieParis Saclay Univ, Univ Paris Cite, Populat Based Cohorts Unit, INSERM,UVSQ, Paris, France.
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Le Marec, HerveNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Jakobsson, MattiasUppsala universitet,Människans evolution(Swepub:uu)matja323
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Darlu, PierreUniv Paris Cite, UMR Ecoanthropol 7206, CNRS, MNHN,Musee Homme, Paris, France.
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Genin, EmmanuelleUniv Brest, Inserm, EFS, UMR 107,GGB, Brest, France.;CHRU Brest, Brest, France.
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Deleuze, Jean-FrancoisUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France.;LabEx GenMed, Evry, France.;Fdn Jean Dausset, CEPH, Paris, France.
(author)
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Redon, RichardNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Dina, ChristianNantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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Nantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.;Univ Strasbourg, CNRS, GMGM, Strasbourg, France.Nantes Univ, Inst Thorax, CHU Nantes, CNRS,INSERM, Nantes, France.
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In:Nature Communications: Springer Nature152041-1723
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Alves, Isabel
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Giemza, Joanna
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Blum, Michael G. ...
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Bernhardsson, Ca ...
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Chatel, Stephani ...
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Karakachoff, Mat ...
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show more...
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Saint Pierre, Au ...
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Herzig, Anthony ...
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Olaso, Robert
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Monteil, Martial
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Gallien, Veroniq ...
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Cabot, Elodie
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Svensson, Emma, ...
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Bacq, Delphine
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Baron, Estelle
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Berthelier, Char ...
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Besse, Celine
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Blanche, Helene
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Bocher, Ozvan
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Boland, Anne
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Bonnaud, Stephan ...
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Charpentier, Eri ...
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Dandine-Roulland ...
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Ferec, Claude
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Fruchet, Christi ...
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Lecointe, Simon
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Le Floch, Edith
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Ludwig, Thomas E ...
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Marenne, Gaelle
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Meyer, Vincent
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Quellery, Elisab ...
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Racimo, Fernando
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Rouault, Karen
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Sandron, Florian
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Schott, Jean-Jac ...
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Velo-Suarez, Lou ...
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Violleau, Jade
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Willerslev, Eske
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Coativy, Yves
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Jezequel, Mael
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Le Bris, Daniel
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Nicolas, Clement
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Pailler, Yvan
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Goldberg, Marcel
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Zins, Marie
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Le Marec, Herve
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Jakobsson, Matti ...
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Darlu, Pierre
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Genin, Emmanuell ...
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Deleuze, Jean-Fr ...
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Redon, Richard
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Dina, Christian
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Uppsala University