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Genome-wide analyse...
Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions
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- Lindström, Sara (författare)
- Department of Epidemiology, University of Washington, WA, Seattle, United States; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Wang, Lu (författare)
- Department of Environmental and Occupational Health Sciences, University of Washington, WA, Seattle, United States
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- Feng, Helian (författare)
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Majumdar, Arunabha (författare)
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, CA, Los Angeles, United States; Department of Mathematics, Indian Institute of Technology Hyderabad, Telangana, Kandi, India
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- Huo, Sijia (författare)
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Macdonald, James (författare)
- Department of Environmental and Occupational Health Sciences, University of Washington, WA, Seattle, United States
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- Harrison, Tabitha (författare)
- Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Turman, Constance (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Chen, Hongjie (författare)
- Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Mancuso, Nicholas (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Bammler, Theo (författare)
- Department of Environmental and Occupational Health Sciences, University of Washington, WA, Seattle, United States
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- Gallinger, Steve (författare)
- Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
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- Gruber, Stephen B. (författare)
- Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Le Marchand, Loic (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Moreno, Victor (författare)
- Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
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- Offit, Kenneth (författare)
- Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA
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- De Vivo, Immaculata (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
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- O'Mara, Tracy A. (författare)
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia
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- Spurdle, Amanda B. (författare)
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia
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- Tomlinson, Ian (författare)
- Cancer Research Centre, University of Edinburgh, Edinburgh, United Kingdom
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- Fitzgerald, Rebecca (författare)
- MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
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- Gharahkhani, Puya (författare)
- Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
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- Gockel, Ines (författare)
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany
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- Jankowski, Janusz (författare)
- University College London, United Kingdom; University of the South Pacific, Suva, Fiji
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- Macgregor, Stuart (författare)
- Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
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- Schumacher, Johannes (författare)
- Center for Human Genetics, University Hospital of Marburg, Marburg, Germany
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- Barnholtz-Sloan, Jill (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; Trans-Divisional Research Program, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Bondy, Melissa L. (författare)
- Department of Epidemiology and Population Health, Stanford University, CA, Palo Alto, United States
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- Houlston, Richard S. (författare)
- Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
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- Jenkins, Robert B. (författare)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, MN, Rochester, United States
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- Melin, Beatrice S. (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Wrensch, Margaret (författare)
- Department of Neurological Surgery, University of California, CA, San Francisco, United States
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- Brennan, Paul (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Christiani, David C. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Environmental Health, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Mckay, James (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Aldrich, Melinda C. (författare)
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Landi, Maria Teresa (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Tardon, Adonina (författare)
- University Institute of Oncology of the Principality of Asturias (IUOPA), University of Oviedo and Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Oviedo, Spain
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- Bishop, D Timothy (författare)
- Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom
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- Demenais, Florence (författare)
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
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- Goldstein, Alisa M. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Iles, Mark M. (författare)
- Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom
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- Kanetsky, Peter A. (författare)
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
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- Law, Matthew H. (författare)
- Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
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- Amundadottir, Laufey T. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Stolzenberg-Solomon, Rachael (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Wolpin, Brian M. (författare)
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States
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- Klein, Alison (författare)
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, MD, Baltimore, United States; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, MD, Baltimore, United States
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- Petersen, Gloria (författare)
- Department of Quantitative Health Science, Mayo Clinic, MN, Rochester, United States
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- Risch, Harvey (författare)
- Yale School of Public Health, Chronic Disease Epidemiology, CT, New Haven, United States
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- Chanock, Stephen J. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Purdue, Mark P. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Scelo, Ghislaine (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Pharoah, Paul (författare)
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Kar, Siddhartha (författare)
- Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Hung, Rayjean J. (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbuaum Research Institute, Sinai Health System, ON, Toronto, Canada
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- Pasaniuc, Bogdan (författare)
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, CA, Los Angeles, United States; Department of Human Genetics, David Geffen School of Medicine, University of California, CA, Los Angeles, United States; Department of Computational Medicine, David Geffen School of Medicine, University of California, CA, Los Angeles, United States
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- Kraft, Peter (författare)
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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(creator_code:org_t)
- 2023-03-17
- 2023
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 115:6, s. 712-732
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.METHODS: We collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers. We conducted cross-cancer GWAS and transcriptome-wide association studies to discover novel cancer susceptibility loci. Finally, we assessed the extent of variant-specific pleiotropy among cancers at known and newly identified cancer susceptibility loci.RESULTS: We observed widespread but modest genome-wide genetic correlations across cancers. In cross-cancer GWAS and transcriptome-wide association studies, we identified 15 novel cancer susceptibility loci. Additionally, we identified multiple variants at 77 distinct loci with strong evidence of being associated with at least 2 cancer types by testing for pleiotropy at known cancer susceptibility loci.CONCLUSIONS: Overall, these results suggest that some genetic risk variants are shared among cancers, though much of cancer heritability is cancer-specific and thus tissue-specific. The increase in statistical power associated with larger sample sizes in cross-disease analysis allows for the identification of novel susceptibility regions. Future studies incorporating data on multiple cancer types are likely to identify additional regions associated with the risk of multiple cancer types.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- Av författaren/redakt...
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Lindström, Sara
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Wang, Lu
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Feng, Helian
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Majumdar, Arunab ...
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Huo, Sijia
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Macdonald, James
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visa fler...
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Harrison, Tabith ...
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Turman, Constanc ...
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Chen, Hongjie
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Mancuso, Nichola ...
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Bammler, Theo
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Gallinger, Steve
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Gruber, Stephen ...
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Gunter, Marc J.
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Le Marchand, Loi ...
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Moreno, Victor
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Offit, Kenneth
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De Vivo, Immacul ...
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O'Mara, Tracy A.
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Spurdle, Amanda ...
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Tomlinson, Ian
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Fitzgerald, Rebe ...
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Gharahkhani, Puy ...
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Gockel, Ines
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Jankowski, Janus ...
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Macgregor, Stuar ...
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Schumacher, Joha ...
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Barnholtz-Sloan, ...
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Bondy, Melissa L ...
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Houlston, Richar ...
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Jenkins, Robert ...
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Melin, Beatrice ...
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Wrensch, Margare ...
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Brennan, Paul
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Christiani, Davi ...
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Johansson, Matti ...
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Mckay, James
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Aldrich, Melinda ...
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Amos, Christophe ...
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Landi, Maria Ter ...
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Tardon, Adonina
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Bishop, D Timoth ...
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Demenais, Floren ...
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Goldstein, Alisa ...
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Iles, Mark M.
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Kanetsky, Peter ...
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Law, Matthew H.
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Amundadottir, La ...
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Stolzenberg-Solo ...
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Wolpin, Brian M.
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Klein, Alison
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Petersen, Gloria
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Risch, Harvey
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Chanock, Stephen ...
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Purdue, Mark P.
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Scelo, Ghislaine
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Pharoah, Paul
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Kar, Siddhartha
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Hung, Rayjean J.
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Pasaniuc, Bogdan
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Kraft, Peter
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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Journal of the N ...
- Av lärosätet
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Umeå universitet