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Circulating insulin...
Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer : a collaborative analysis of 20 prospective studies and Mendelian randomization analysis
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- Watts, Eleanor L. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Perez-Cornago, Aurora (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Fensom, Georgina K. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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visa fler...
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- Smith-Byrne, Karl (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France,Int Agcy Res Canc, Genom Epidemiol Branch, Lyon, France.
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- Noor, Urwah (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Andrews, Colm D. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Gunter, Marc J. (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France,Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France.
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- Holmes, Michael V. (författare)
- Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTS, Oxford, England.;Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England.
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- Martin, Richard M. (författare)
- Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom; National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, Univ. Hospitals Bristol NHS Found. Trust and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom,Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England.;Univ Hosp Bristol NHS Fdn Trust & Weston NHS Fdn, Natl Inst Hlth Res NIHR Bristol Biomed Res Ctr, Bristol, Avon, England.
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- Tsilidis, Konstantinos K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece.
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.
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- Barricarte, Aurelio (författare)
- Group of Epidemiology of Cancer and Other Chronic Diseases, Navarra Public Health Institute, Pamplona, Spain; Group of Epidemiology of Cancer and Other Chronic Diseases, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain,Navarra Publ Hlth Inst, Grp Epidemiol Canc & Other Chron Dis, Pamplona, Spain.;Navarra Inst Hlth Res IdiSNA, Grp Epidemiol Canc & Other Chron Dis, Pamplona, Spain.
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- Bueno-De-Mesquita, H. Bas (författare)
- Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Utrecht, Netherlands,Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr Prevent & Hlth Serv, Utrecht, Netherlands.
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- Cohn, Barbara A. (författare)
- Child Health and Development Studies, Public Health Institute, CA, Berkeley, United States,Inst Publ Hlth, Child Hlth & Dev Studies, Berkeley, CA USA.
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- Deschasaux-Tanguy, Melanie (författare)
- Sorbonne Paris Nord University, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center, University of Paris, Bobigny, France,Univ Paris, Sorbonne Paris Nord Univ, Epidemiol & Stat Res Ctr, Nutr Epidemiol Res Team, Bobigny, France.
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- Dimou, Niki L. (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France,Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France.
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- Ferrucci, Luigi (författare)
- National Institute on Aging, MD, Baltimore, United States,NIA, Baltimore, MD 21224 USA.
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- Flicker, Leon (författare)
- WA Centre for Health & Ageing, Medical School, University of Western Australia, WA, Perth, Australia; Western Australian Centre for Health and Ageing, University of Western Australia, WA, Perth, Australia,Univ Western Australia, Sch Med, WA Ctr Hlth & Ageing, Perth, WA, Australia.;Univ Western Australia, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia.
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- Freedman, Neal D. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Giles, Graham G. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Melbourne, Australia,Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia.
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- Giovannucci, Edward L. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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- Haiman, Christopher A. (författare)
- Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States,Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr,Ctr Genet Epidemiol, Los Angeles, CA USA.
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- Hankey, Graham J. (författare)
- WA Centre for Health & Ageing, Medical School, University of Western Australia, WA, Perth, Australia,Univ Western Australia, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia.
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- Holly, Jeffrey M. P. (författare)
- IGFs & Metabolic Endocrinology Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom,Univ Bristol, Bristol Med Sch, IGFs Metab Endocrinol Grp, Translat Hlth Sci, Bristol, Avon, England.
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- Huang, Jiaqi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;Cent South Univ, Natl Clin Res Ctr Metab Dis, Key Lab Diabet Immunol, Minist Educ, Changsha, Hunan, Peoples R China.;Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Hunan, Peoples R China.
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- Huang, Wen-Yi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Hurwitz, Lauren M. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
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- Kubo, Tatsuhiko (författare)
- Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan,Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Publ Hlth & Hlth Policy, Hiroshima, Japan.
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- Le Marchand, Loic (författare)
- University of Hawaii, Cancer Center, HI, Honolulu, United States,Univ Hawaii, Ctr Canc, Honolulu, HI USA.
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- Macinnis, Robert J. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Melbourne, Australia,Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
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- Männistö, Satu (författare)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland.
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- Metter, E. Jeffrey (författare)
- Department of Neurology, College of Medicine, University of Tennessee Health Science Center, TN, Memphis, United States,Univ Tennessee Hlth Sci Ctr, Dept Neurol, Coll Med, Memphis, TN USA.
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- Mikami, Kazuya (författare)
- Departmemt of Urology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan,Japanese Red Cross Kyoto Daiichi Hosp, Dept Urol, Kyoto, Japan.
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- Mucci, Lorelei A. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
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- Olsen, Anja W. (författare)
- Department of Public Health, Aarhus University, Aarhus, Denmark; Danish Cancer Society, Research Center, Copenhagen, Denmark,Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Danish Canc Soc, Res Ctr, Copenhagen, Denmark.
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- Ozasa, Kotaro (författare)
- Departmemt of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan,Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan.
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy,Inst Canc Res, Canc Risk Factors & Life Style Epidemiol Unit, Prevent & Clin Network, Florence, Italy.
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- Penney, Kathryn L. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States,Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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- Pollak, Michael N. (författare)
- Departments of Medicine and Oncology, McGill University, QC, Montreal, Canada,McGill Univ, Dept Med, Montreal, PQ, Canada.
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- Roobol, Monique J. (författare)
- Department of Urology, Erasmus University Medical Center, Rotterdam, Netherlands,McGill Univ, Dept Oncol, Montreal, PQ, Canada.
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- Schaefer, Catherine A. (författare)
- Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States,Erasmus MC, Dept Urol, Rotterdam, Netherlands.
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- Schenk, Jeannette M. (författare)
- Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
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- Stattin, Pär (författare)
- Uppsala universitet,Urologkirurgi
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- Tamakoshi, Akiko (författare)
- Department of Public Health, Faculty of Medicine, Hokkaido University , Sapporo, Japan
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- Thysell, Elin (författare)
- Umeå universitet,Patologi,Hokkaido Univ, Dept Publ Hlth, Fac Med, Sapporo, Hokkaido, Japan.
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- Tsai, Chiaojung Jillian (författare)
- Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, NY, New York, United States,Umeå Univ, Dept Med Biosci, Umeå, Sweden.
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- Touvier, Mathilde (författare)
- Sorbonne Paris Nord University, Nutritional Epidemiology Research Team, Epidemiology and Statistics Research Center, University of Paris, Bobigny, France
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- Van Den Eeden, Stephen K. (författare)
- Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Urology, University of California San Francisco, CA, San Francisco, United States,Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA.
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- Weiderpass, Elisabete (författare)
- Director's Office, International Agency for Research on Cancer, World Health Organization, Lyon, France,Univ Calif San Francisco, Dept Urol, San Francisco, CA USA.
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- Weinstein, Stephanie J. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Wilkens, Lynne R. (författare)
- University of Hawaii, Cancer Center, HI, Honolulu, United States
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- Yeap, Bu B. (författare)
- WA Centre for Health & Ageing, Medical School, University of Western Australia, WA, Perth, Australia; Department of Endocrinology and Diabetes, Fiona Stanley Hospital, WA, Perth, Australia,Int Agcy Res Canc, Directors Off, WHO, Lyon, France.
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- Allen, Naomi E. (författare)
- Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; UK Biobank Ltd, Stockport, United Kingdom,Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia.;UK Biobank Ltd, Stockport, Lancs, England.
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- Key, Timothy J. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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- Travis, Ruth C. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
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Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England (creator_code:org_t)
- 2022-06-21
- 2023
- Engelska.
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Ingår i: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 52:1, s. 71-86
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of genetically predicted IGF-I with aggressive prostate cancer is not known. We aimed to investigate the associations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 concentrations with overall, aggressive and early-onset prostate cancer.Methods: Prospective analysis of biomarkers using the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset (up to 20 studies, 17 009 prostate cancer cases, including 2332 aggressive cases). Odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer were estimated using conditional logistic regression. For IGF-I, two-sample Mendelian randomization (MR) analysis was undertaken using instruments identified using UK Biobank (158 444 men) and outcome data from PRACTICAL (up to 85 554 cases, including 15 167 aggressive cases). Additionally, we used colocalization to rule out confounding by linkage disequilibrium.Results: In observational analyses, IGF-I was positively associated with risks of overall (OR per 1 SD = 1.09: 95% CI 1.07, 1.11), aggressive (1.09: 1.03, 1.16) and possibly early-onset disease (1.11: 1.00, 1.24); associations were similar in MR analyses (OR per 1 SD = 1.07: 1.00, 1.15; 1.10: 1.01, 1.20; and 1.13; 0.98, 1.30, respectively). Colocalization also indicated a shared signal for IGF-I and prostate cancer (PP4: 99%). Men with higher IGF-II (1.06: 1.02, 1.11) and IGFBP-3 (1.08: 1.04, 1.11) had higher risks of overall prostate cancer, whereas higher IGFBP-1 was associated with a lower risk (0.95: 0.91, 0.99); these associations were attenuated following adjustment for IGF-I.Conclusions: These findings support the role of IGF-I in the development of prostate cancer, including for aggressive disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- aggressive prostate cancer
- Insulin-like growth factor-I
- international consortia
- Mendelian randomization
- prospective analysis
- prostate cancer
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Watts, Eleanor L ...
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Perez-Cornago, A ...
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Fensom, Georgina ...
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Smith-Byrne, Kar ...
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Noor, Urwah
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Andrews, Colm D.
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visa fler...
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Gunter, Marc J.
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Holmes, Michael ...
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Martin, Richard ...
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Tsilidis, Konsta ...
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Albanes, Demetri ...
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Barricarte, Aure ...
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Bueno-De-Mesquit ...
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Cohn, Barbara A.
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Deschasaux-Tangu ...
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Dimou, Niki L.
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Ferrucci, Luigi
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Flicker, Leon
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Freedman, Neal D ...
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Giles, Graham G.
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Giovannucci, Edw ...
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Haiman, Christop ...
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Hankey, Graham J ...
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Holly, Jeffrey M ...
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Huang, Jiaqi
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Huang, Wen-Yi
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Hurwitz, Lauren ...
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Kaaks, Rudolf
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Kubo, Tatsuhiko
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Le Marchand, Loi ...
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Macinnis, Robert ...
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Männistö, Satu
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Metter, E. Jeffr ...
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Mikami, Kazuya
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Mucci, Lorelei A ...
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Olsen, Anja W.
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Ozasa, Kotaro
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Palli, Domenico
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Penney, Kathryn ...
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Platz, Elizabeth ...
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Pollak, Michael ...
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Roobol, Monique ...
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Schaefer, Cather ...
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Schenk, Jeannett ...
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Stattin, Pär
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Tamakoshi, Akiko
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Thysell, Elin
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Tsai, Chiaojung ...
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Touvier, Mathild ...
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Van Den Eeden, S ...
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Weiderpass, Elis ...
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Weinstein, Steph ...
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Wilkens, Lynne R ...
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Yeap, Bu B.
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Allen, Naomi E.
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Key, Timothy J.
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Travis, Ruth C.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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Umeå universitet
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Uppsala universitet