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Mosaic chromosomal ...
Mosaic chromosomal alterations are associated with increased lung cancer risk : insight from the INTEGRAL-ILCCO cohort analysis
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- Cheng, Chao (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States
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- Hong, Wei (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States
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- Li, Yafang (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States
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- Xiao, Xiangjun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States
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- McKay, James (författare)
- Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France
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- Han, Younghun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States
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- Byun, Jinyoung (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States
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- Peng, Bo (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States
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- Albanes, Demetrios (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda, United States
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- Lam, Stephen (författare)
- Department of Integrative Oncology, University of British Columbia, BC, Vancouver, Canada
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- Tardon, Adonina (författare)
- Public Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain
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- Chen, Chu (författare)
- Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Bojesen, Stig E. (författare)
- Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Landi, Maria T. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda, United States
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- Johansson, Mattias (författare)
- Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France
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- Risch, Angela (författare)
- Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria
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- Bickeböller, Heike (författare)
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany
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- Wichmann, H-Erich (författare)
- Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany
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- Christiani, David C. (författare)
- Department of Environmental Health, Harvard T.H. Chan School of Public Health, Massachusetts, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Massachusetts, Boston, United States
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- Rennert, Gad (författare)
- Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
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- Arnold, Susanne (författare)
- University of Kentucky, Markey Cancer Center, Kentucky, Lexington, United States
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- Goodman, Gary (författare)
- Swedish Cancer Institute, WA, Seattle, United States
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- Field, John K. (författare)
- Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
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- Davies, Michael P.A. (författare)
- Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
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- Shete, Sanjay S. (författare)
- Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Texas, Houston, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Texas, Houston, United States
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- Le Marchand, Loic (författare)
- Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States
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- Liu, Geoffrey (författare)
- University Health Network- The Princess Margaret Cancer Centre, California, Toronto, United States
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- Hung, Rayjean J. (författare)
- Luenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
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- Andrew, Angeline S. (författare)
- Department of Epidemiology, Dartmouth College, New Hampshire, Hanover, United States; Department of Community and Family Medicine, Dartmouth College, New Hampshire, Hanover, United States
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- Kiemeney, Lambertus A. (författare)
- Radboud University Medical Center, Nijmegen, Netherlands
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- Zhu, Meng (författare)
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
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- Shen, Hongbing (författare)
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
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- Zienolddiny, Shan (författare)
- National Institute of Occupational Health, Oslo, Norway
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- Grankvist, Kjell (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Johansson, Mikael (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Cox, Angela (författare)
- Academic Unit of Clinical Oncology University of Sheffield, Weston Park Hospital, Whitham Road, Sheffield, United Kingdom
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- Hong, Yun-Chul (författare)
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
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- Yuan, Jian-Min (författare)
- University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, PA, Pittsburgh, United States
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- Lazarus, Philip (författare)
- Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States
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- Schabath, Matthew B. (författare)
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Florida, Tampa, United States
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- Aldrich, Melinda C. (författare)
- Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
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- Brennan, Paul (författare)
- Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France
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- Li, Yong (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States
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- Gorlova, Olga (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States
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- Gorlov, Ivan (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Journal of Thoracic Oncology. - : Elsevier. - 1556-0864 .- 1556-1380. ; 18:8, s. 1003-1016
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Mosaic chromosomal alterations (mCAs) detected in white blood cells represent a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic mutations. A few recent studies indicated their potential link with nonhematological cancers, especially lung cancer. Methods: In this study, we investigated the association between mCAs and lung cancer using the high-density genotyping data from the OncoArray study of INTEGRAL-ILCCO, the largest single genetic study of lung cancer with 18,221 lung cancer cases and 14,825 cancer-free controls. Results: We identified a comprehensive list of autosomal mCAs, ChrX mCAs, and mosaic ChrY (mChrY) losses from these samples. Autosomal mCAs were detected in 4.3% of subjects, in addition to ChrX mCAs in 3.6% of females and mChrY losses in 9.6% of males. Multivariable logistic regression analysis indicated that the presence of autosomal mCAs in white blood cells was associated with an increased lung cancer risk after adjusting for key confounding factors, including age, sex, smoking status, and race. This association was mainly driven by a specific type of mCAs: copy-neutral loss of heterozygosity on autosomal chromosomes. The association between autosome copy-neutral loss of heterozygosity and increased risk of lung cancer was further confirmed in two major histologic subtypes, lung adenocarcinoma and squamous cell carcinoma. In addition, we observed a significant increase of ChrX mCAs and mChrY losses in smokers compared with nonsmokers and racial differences in certain types of mCA events. Conclusions: Our study established a link between mCAs in white blood cells and increased risk of lung cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Clonal hematopoiesis
- Loss of heterozygosity
- Lung cancer risk
- Mosaic chromosomal alterations
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Cheng, Chao
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Hong, Wei
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Li, Yafang
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Xiao, Xiangjun
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McKay, James
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Han, Younghun
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visa fler...
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Byun, Jinyoung
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Peng, Bo
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Albanes, Demetri ...
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Lam, Stephen
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Tardon, Adonina
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Chen, Chu
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Bojesen, Stig E.
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Landi, Maria T.
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Johansson, Matti ...
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Risch, Angela
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Bickeböller, Hei ...
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Wichmann, H-Eric ...
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Christiani, Davi ...
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Rennert, Gad
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Arnold, Susanne
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Goodman, Gary
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Field, John K.
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Davies, Michael ...
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Shete, Sanjay S.
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Le Marchand, Loi ...
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Liu, Geoffrey
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Hung, Rayjean J.
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Andrew, Angeline ...
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Kiemeney, Lamber ...
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Zhu, Meng
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Shen, Hongbing
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Zienolddiny, Sha ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Cox, Angela
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Hong, Yun-Chul
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Yuan, Jian-Min
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Brennan, Paul
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Li, Yong
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Gorlova, Olga
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Gorlov, Ivan
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Amos, Christophe ...
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