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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008595naa a2200625 4500
001oai:DiVA.org:umu-214066
003SwePub
008230905s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2140662 URI
0247 a https://doi.org/10.1136/bmjresp-2023-0017602 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bertels, Xanderu Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands4 aut
2451 0a Phenotyping asthma with airflow obstruction in middle-aged and older adults :b a CADSET clinical research collaboration
264 1b BMJ Publishing Group Ltd,c 2023
338 a electronic2 rdacarrier
520 a BACKGROUND: The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.METHODS: This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC <0.7 in population-based and clinic-based cohorts, respectively. Clinical characteristics and comorbidities of AO were compared with asthma without airflow obstruction (asthma-only) and chronic obstructive pulmonary disease (COPD) without asthma history (COPD-only). ORs for comorbidities adjusted for age, sex, smoking status and body mass index (BMI) were meta-analysed using a random effects model.RESULTS: The prevalence of AO was 2.1% (95% CI 2.0% to 2.2%) in population-based, 21.1% (95% CI 18.6% to 23.8%) in asthma-based and 16.9% (95% CI 15.8% to 17.9%) in COPD-based cohorts. AO patients had more often clinically relevant dyspnoea (modified Medical Research Council score ≥2) than asthma-only (+14.4 and +14.7 percentage points) and COPD-only (+24.0 and +5.0 percentage points) in population-based and clinic-based cohorts, respectively. AO patients had more often elevated blood eosinophil counts (>300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1.68 (95% CI 1.06 to 2.68)) than COPD-only, independent of age, sex, smoking status and BMI.CONCLUSIONS: AO is a relatively prevalent respiratory phenotype associated with more dyspnoea and a higher risk of coronary artery disease and elevated blood eosinophil counts in the general population compared with both asthma-only and COPD-only.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a Asthma
653 a Asthma Epidemiology
653 a Clinical Epidemiology
653 a COPD epidemiology
653 a Pulmonary Disease
653 a Chronic Obstructive
7001 a Edris, Ahmedu Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands4 aut
7001 a Garcia-Aymerich, Judithu Non-Communicable Diseases and Environment Programme, ISGlobal, Barcelona, Spain; Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain4 aut
7001 a Faner, Rosau Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain4 aut
7001 a Meteran, Howramanu Department of Respiratory Medicine, Copenhagen University Hospital-Amager and Hvidovre, Denmark; Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark4 aut
7001 a Sigsgaard, Torbenu Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark4 aut
7001 a Alter, Peteru Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany4 aut
7001 a Vogelmeier, Clausu Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany; Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria4 aut
7001 a Olvera, Nuriau Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain4 aut
7001 a Kermani, Nazanin Zounematu National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Agusti, Alvaru Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; Respiratory Institute, Hospital Clinic de Barcelona, Barcelona, Spain4 aut
7001 a Donaldson, Gavin C.u National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Wedzicha, Jadwiga A.u National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Brusselle, Guy G.u Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium4 aut
7001 a Backman, Helenau Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)heaban01
7001 a Rönmark, Evau Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)evra0004
7001 a Lindberg, Anneu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)anelig02
7001 a Vonk, Judith M.u Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands4 aut
7001 a Chung, Kian Fanu National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a Adcock, Ian M.u National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom4 aut
7001 a van den Berge, Maartenu Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands; Department of Pulmonology, University Medical Centre Groningen, Groningen, Netherlands4 aut
7001 a Lahousse, Liesu Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands4 aut
7102 a Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlandsb Non-Communicable Diseases and Environment Programme, ISGlobal, Barcelona, Spain; Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain4 org
7730 t BMJ open respiratory researchd : BMJ Publishing Group Ltdg 10:1q 10:1x 2052-4439
8564 u https://doi.org/10.1136/bmjresp-2023-001760y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1794318/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214066
8564 8u https://doi.org/10.1136/bmjresp-2023-001760

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